Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P39060 (endostatin)
 2,284 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
endostatin 2284
vascular endothelial growth factor 365
Endostatin 312
Sep 168
VEGF 152
collagen 144
Mol 132
thrombospondin 77
matrix metalloproteinase 46
CD31 42
perlecan 40
tyrosine kinase 40
VEGFR2 37
MMP-9 36
cytokine 33
MMP-2 32
Vascular endothelial growth factor 30
proteoglycan 28
endogenous angiogenesis inhibitor 26
p53 25
angiogenin 24
fibronectin 24
vascular endothelial growth factor receptor 24
NMR 23
plasminogen 23
polypeptide 22
TMN 22
agrin 22
epidermal growth factor receptor 22
caspase-3 22
COL18A1 21
mTOR 20
platelet-derived growth factor 20
vascular endothelial growth factor A 19
FGF 19
tumor necrosis factor 19
bFGF 19
platelet-derived 19
ACS 18
ATP 18
vascular endothelial growth factor receptor 2 17
hepatocyte growth factor 17
Plasmin 16
KDR 16
endoglin 15
vascular endothelium 15
angiopoietin-1 15
CD34 14
interferon 14
FGF-2 14
PDGF 14
nitric oxide synthase 14
p38 14
pigment epithelium-derived factor 14
ATPase 14
PEG 14
SDS 14
frizzled 13
ERK1 13
VEGFR-1 13
MRI 13
type XV collagen 12
hemoglobin 12
ERK 12
HPO 12
angiopoietin-2 12
placental growth factor 12
receptor tyrosine kinase 11
Pseudomonas 11
metalloproteinase 11
restin 11
fused 11
NADH 11
osteopontin 11
cyclin D1 10
nucleolin 10
TNF 10
EPR 10
glycoprotein 10
colon carcinoma 10
TIMP-2 10
PLA 10
glutamine synthetase 10
cage 10
cryptic 9
osteosarcoma 9
catenin 9
IFN 9
epidermal growth factor 9
smooth muscle actin 9
HER2 9
platelet factor 4 9
urokinase-type plasminogen activator 9
nidogen 9
EPA 9
kit 9
CD105 9
TEM 9
heparan sulfate proteoglycan 8
PEDF 8
HIF-1 8
CXCL10 8
core protein 8
alkaline phosphatase 8
TSP 8
ADP 8
carcinoembryonic antigen 8
Bcl-2 8
proliferating cell nuclear antigen 8
insulin 8
decorin 8
cathepsin L 8
MMP 8
vascular cell adhesion molecule-1 8
Cytokine 8
p21 8
VEGF-C 7
ENDO 7
FDG 7
EGFR 7
chemokine 7
tumor necrosis factor alpha 7
IL-6 7
CgA 7
PI3K 7
MAPK 7
bradykinin 7
plasminogen activator inhibitor-1 7
MMP9 7
vitronectin 7
C-reactive protein 7
IL-8 7
survivin 7
COX-2 7
proteasome 7
versican 7
CTX 7
transforming growth factor-beta 7
interleukin-6 6
annexin V 6
AKT 6
ECM 6
extracellular matrix protein 6
p27 6
cyclooxygenase-2 6
biglycan 6
insulin-like growth factor 6
hinge 6
caspase-9 6
canstatin 6
prolactin 6
membrane-bound 6
EGF 6
metalloprotease 6
SMA 6
cyclin E 6
focal adhesion kinase 6
NOD 6
Platelet factor 4 6
endothelin-1 6
more...
Disease
KNO 634
tumor 604
cancer 574
tumor growth 316
tumor angiogenesis 99
metastases 72
breast cancer 71
tumor progression 63
carcinoma 60
lung cancer 53
hepatocellular carcinoma 52
lung carcinoma 45
colorectal cancer 41
non-small cell lung cancer 39
glioma 36
prostate cancer 35
tumor vasculature 34
melanoma 32
hypertension 32
adenocarcinoma 27
renal cell carcinoma 27
glioblastoma 27
colon cancer 27
diabetes 26
primary tumor 25
ovarian cancer 25
squamous cell carcinoma 23
rheumatoid arthritis 21
gastric cancer 20
macular degeneration 20
diabetic retinopathy 18
carcinogenesis 18
liver cancer 18
ischemia 18
tumorigenesis 18
arthritis 17
multiple myeloma 16
stroke 16
cornea 15
PSS 14
lung metastases 14
solid tumor 14
SDS 14
leukemia 13
glioblastoma multiforme 13
atherosclerosis 13
liver cancer 13
heart failure 13
mole 12
acute myeloid leukemia 12
pancreatic cancer 12
mole 12
SCID 12
epithelial ovarian cancer 11
proteinuria 11
brain tumor 11
MCF 11
neutropenia 11
obesity 11
Alzheimer's disease 11
brain metastases 10
myocardial infarction 10
metastatic breast cancer 10
Hepatocellular carcinoma 9
blindness 9
coronary artery disease 9
liver metastases 9
TEM 9
TEM 9
osteosarcoma 9
cervical cancer 8
neuroblastoma 8
cardiovascular disease 8
metastatic renal cell carcinoma 8
mammary tumor 8
vitreoretinal degeneration 8
endometriosis 8
anemia 8
sarcoma 7
mimicry 7
bladder cancer 7
cirrhosis 7
CTX 7
cold 7
retinopathy 7
lymphatic vessels 6
preeclampsia 6
retinopathy of prematurity 6
retinal detachment 6
renal disease 6
acute lymphoblastic leukemia 6
malignant ascites 6
diabetic nephropathy 6
lymphoma 6
myopia 6
HGF 6
NOD 6
myelosuppression 5
CAM 5
carcinomatosis 5
osteoarthritis 5
aggressiveness 5
dementia 5
small cell lung cancer 5
Age-related macular degeneration 5
recurrent ovarian cancer 5
NAME 5
SEM 5
type 2 diabetes 5
rash 5
leukopenia 5
hemangioendothelioma 5
hand-foot syndrome 5
fibrosarcoma 5
angiosarcoma 4
pulmonary hypertension 4
psoriasis 4
congestive heart failure 4
dehydration 4
cytomegalovirus 4
hemangioma 4
hypercholesterolemia 4
PSA 4
macular edema 4
coronary heart disease 4
HIV 4
chronic lymphocytic leukemia 4
familial adenomatous polyposis 4
thrombocytopenia 4
herpes simplex 4
Placenta 4
EIA 4
chronic lymphocytic leukemia 4
Down syndrome 4
metastatic melanoma 4
scleroderma 4
acute myocardial infarction 4
Tumour necrosis 3
Caries 3
esophageal cancer 3
HCC 3
dental caries 3
chlorosis 3
emphysema 3
cerebral ischemia 3
fatty liver 3
hyperglycemia 3
arteriopathy 3
Kaposi's sarcoma 3
tuberculosis 3
Leukemia 3
medullary thyroid carcinoma 3
vascular disease 3
rhabdomyosarcoma 3
glomerulonephritis 3
pulmonary fibrosis 3
astrocytoma 3
cognitive impairment 3
suicide 3
WT1 3
more...
Symptom
diarrhea 12
fatigue 10
pain 9
nausea 7
starvation 6
vomiting 6
acidity 5
hemoptysis 4
agitation 4
overweight 4
collapse 4
hyperoxia 3
constipation 3
tremor 3
headache 3
nausea and vomiting 3
chest pain 3
thinning 3
cough 2
anorexia 2
weakness 2
functional recovery 2
anesthesia 2
cyanosis 1
Halo 1
atypical chest pain 1
sleepiness 1
dysarthria 1
dyspnea 1
discomfort 1
dry eye 1
lethargy 1
flushing 1
abdominal cramps 1
discomfort 1
insomnia 1
microbial colonization 1
Continuous leakage 1
Wind 1
hypotonia 1
hypoproteinemia 1
respiratory distress 1
hepatosplenomegaly 1
asthenia 1
seizures 1
numbness 1
hoarseness 1
ataxia 1
rigors 1
Drug
Bevacizumab 48
lysine 11
NADH 11
CTX 10
ascorbate 8
Bifidobacterium 7
CTX 7
CTX 7
Leaf 6
citric acid 6
CAM 5
vitamin E 5
Monit 4
Everolimus 4
Sorafenib 4
Dermatol 4
ROC 4
Cetuximab 4
MAP 3
IL-2 3
NaI 3
Alanine 3
IFN-gamma 3
Gel 3
Docetaxel 3
NaI 3
uPA 3
NaI 3
NaI 3
KGF 3
CSF 3
Nephron 2
LMWH 2
Cardiovasc 2
Sensodyne 2
Nitric Oxide 2
Spectrum 2
Gentian violet 2
CTT 2
RbCl 2
RbCl 2
TES 2
TAC 2
Fragment 2
ROS 2
Itraconazole 2
Adriamycin 2
ABC 2
CoCl2 2
Etoposide 2
Erlotinib 2
CoCl2 2
PZC 2
IL-1ra 2
EHDP 2
DPA 2
Doyle 1
ampicillin 1
MOF 1
Proleukin 1
Hyperforin 1
Xanthium 1
Talc 1
Magnesium phosphate 1
Zoledronic acid 1
Sunitinib malate 1
EPI 1
Gefitinib 1
Gelatin 1
Rituximab 1
NOV 1
Arsenic trioxide 1
Vinorelbine 1
Simvastatin 1
Orphan 1
AMC 1
Malachite Green 1
GEO 1
Axitinib 1
Marimastat 1
Pipamperone 1
Ranitidine 1
Dextrose 1
Navelbine 1
Herceptin 1
Asn 1
Orlistat 1
Imiquimod 1
Glycyrrhiza 1
Irinotecan 1
Activin 1
Taxol 1
Citric acid 1
ICI 1
CPT-11 1
Acacia 1
Omeprazole 1
PTH 1
niacin 1
Zoledronic acid 1
CTA 1
Bortezomib 1
anti-CD33 1
Glutathione 1
BH4 1
Silica 1
2-Methoxyestradiol 1
MRC 1
IFN-beta 1
Ammonium chloride 1
Indomethacin 1
Perindopril 1
Trifluoroethanol 1
Enzyme
ERK 69
mitogen-activated protein kinase 32
nitrate reductase 31
nitrate reductase 29
nitrate reductase 29
nitrate reductase 29
nitrate reductase 29
nitrate reductase 29
caspase-3 20
ACS 18
collagenase 17
focal adhesion kinase 16
ATPase 15
luciferase 15
protein kinase 12
urokinase-type plasminogen activator 12
NO synthase 12
glutamine synthetase 10
MMP 10
plasmin 9
proteasome 9
peroxidase 9
TSP-1 9
alkaline phosphatase 8
cathepsin L 8
protein kinase C 7
nitrogenase 7
trypsin 6
thrombin 6
PARP 6
MMP-3 5
nitrite reductase 5
nitrite reductase 5
MAP 5
tissue plasminogen activator 5
caspase-9 5
nitrite reductase 5
NADPH oxidase 5
cytosine deaminase 5
phosphatidylinositol 3-kinase 5
cdc2 4
superoxide dismutase 4
caspase-8 4
MEK 4
catalase 4
lactate dehydrogenase 4
glutathione reductase 4
RNase 4
lipase 4
glutathione S-transferase 4
elastase 4
NOS 4
chymotrypsin 3
ribonuclease 3
guanylate cyclase 3
hyaluronidase 3
sucrose synthase 3
heparinase 3
ribonuclease 3
cathepsin B 3
phosphoenolpyruvate carboxylase 3
RNase 3
ceruloplasmin 3
ACE 3
lysyl oxidase 3
reverse transcriptase 3
beta-galactosidase 2
isocitrate dehydrogenase 2
carbonic anhydrase 2
calcineurin 2
xylanase 2
phospholipase C 2
topoisomerase 2
renin 2
arginine deiminase 2
PAH 2
kallikrein 2
chondroitinase 2
CD13 2
chondroitinase 2
thymidine kinase 2
prostate-specific antigen 2
glucose oxidase 2
MIP 2
glycolate oxidase 2
aspartate aminotransferase 2
ornithine decarboxylase 2
acetylcholinesterase 2
transglutaminase 2
cathepsin S 2
cathepsin D 2
uracil phosphoribosyltransferase 2
xylanase 2
GSK 2
cathepsin V 2
isocitrate dehydrogenase 2
protein phosphatase 2A 2
diaphorase 2
topoisomerase 2
SMP 2
NADPH oxidase 2
AMP-activated protein kinase 2
apyrase 1
proteinase K 1
PAL 1
dihydrofolate reductase 1
carboxypeptidase B 1
MTD 1
ATP synthase 1
CPT 1
sorbitol dehydrogenase 1
lysozyme 1
3-mercaptopyruvate sulfurtransferase 1
4CL 1
CEP 1
invertase 1
SPT 1
prolyl hydroxylase 1
tryptophan hydroxylase 1
hyaluronidase 1
dihydrodipicolinate synthase 1
biliverdin reductase 1
beta-lactamase 1
CPR 1
CPT 1
fatty acid desaturase 1
aspartokinase 1
cellulase 1
NQO1 1
asparaginase 1
complex I 1
EC 2.7.1.90 1
endonuclease 1
SOR 1
urease 1
1-hydroxylase 1
glutathione synthetase 1
proton-translocating ATPase 1
alcohol dehydrogenase 1
acetolactate synthase 1
glutathione peroxidase 1
ECH 1
CTP synthase 1
CEP 1
succinate dehydrogenase 1
carboxypeptidase A 1
aldehyde dehydrogenase 1
delta-aminolevulinic acid dehydratase 1
urease 1
HSD 1
cathepsin G 1
lysyl hydroxylase 1
TPP 1
phosphodiesterase 1
anthranilate synthase 1
AST 1
methane monooxygenase 1
pregnancy-associated plasma protein-A 1
carboxypeptidase E 1
aldehyde dehydrogenase 1
more...
Compound
nitrate 161
Dec 152
water 127
nitrogen 125
Clin 89
oxygen 87
potassium 86
salt 72
sulfate 71
DNA 61
nitric oxide 51
copper 49
sodium 46
phosphate 44
glucose 39
ammonium 39
zinc 38
arginine 33
Collagen 32
urea 30
calcium 29
MTT 27
hydrogen 27
Gly 26
acetate 20
alanine 20
EDTA 20
EDTA 20
Nitrate 19
iron 19
ATP 18
ACS 18
ACS 18
Cu(II) 18
PEG 17
tyrosine 17
NH2 17
PEG 17
cysteine 16
ethanol 15
His 15
silver 15
galactose 14
HCl 14
SDS 14
Asp 13
cadmium 13
nickel 13
MDA 13
Neo 12
glycerol 12
ADP 12
NADH 11
KOH 11
ammonia 11
lysine 11
TNF 10
CTX 10
serine 10
bromide 10
TEM 10
iodine 10
acetic acid 10
proline 9
ClO 9
CO2 9
Heparan sulfate 9
mercury 9
hydroxide 8
pyridine 8
leucine 8
ADP 8
ADP 8
methionine 7
ASA 7
manganese 7
cyanide 7
glutamine 7
glutamate 7
5-FU 7
dUTP 7
creatinine 7
methanol 7
Cardiol 7
chromium 7
phosphorus 7
Phe 6
SCN 6
CAM 6
carbonate 6
aluminum 6
ClO 6
tryptophan 6
acrylamide 6
Nitrite 6
Nitrite 6
tryptophan 6
sulfuric acid 6
tryptophan 6
tryptophan 6
Retinal 6
asparagine 5
aspartic acid 5
acetone 5
DMSO 5
methane 5
acetonitrile 5
vinyl 5
nicotinamide 5
aspartic acid 5
pentose 5
aspartic acid 5
aspartic acid 5
phosphoric acid 5
MgO 5
selenium 5
salicylic acid 5
tin 5
cGMP 4
Triton X-100 4
COS 4
homocysteine 4
Alginate 4
phenol 4
N-acetylcysteine 4
aldehyde 4
aldehyde 4
naphthalene 4
HCO 4
Salt 4
Tris 4
pentose 4
pentose 4
pentose 4
barium 4
NAD 4
cobalt 4
NAD 4
Paclitaxel 3
octyl 3
ornithine 3
PVA 3
DEAE 3
Alanine 3
Congo red 3
octyl 3
isopropanol 3
TOF 3
NTA 3
glutamic acid 3
chromate 3
MAP 3
Docetaxel 3
butyric acid 3
benzene 3
CPA 3
H2S 3
ornithine 3
benzoic acid 3
4-chlorophenyl 3
more...