Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P39060 (
endostatin
)
2,284
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have analysed the expression of the endogenous angiogenesis inhibitor
endostatin
/
collagen XVIII
following stab wound injury and observed a highly significant (p<0.0001) lesional accumulation confined to areas of pan-necrotic injury and developing secondary damage. Maximal cell numbers were detected at Day 14, declining until Day 21 after injury. Further,
endostatin
/
collagen XVIII
(+) monocytic cells accumulated in Virchow-Robin spaces where they formed cell clusters. Besides being prevailingly localised to
ED1
(+) activated microglia/macrophages,
endostatin
/
collagen XVIII
expression was also detected by subendothelial surrounding vessels in the lesioned area. Late and prolonged accumulation of
endostatin
/
collagen XVIII
(+) microglia/macrophages and increased numbers of
endostatin
/
collagen XVIII
(+) subendothelial cells/vessels in areas of vascular pruning and regression, point to a role in the termination of the transient angiogenic response, linked to a "late" inflammatory milieu.
...
PMID:Lesional expression of the endogenous angiogenesis inhibitor endostatin/collagen XVIII following traumatic brain injury (TBI). 1794 95
