Gene/Protein
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Enzyme
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Pivot Concepts:
Gene/Protein
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Enzyme
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Target Concepts:
Gene/Protein
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Query: UNIPROT:P39060 (
endostatin
)
2,284
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An efficient green chemistry approach to the synthesis of N-substituted piperidones and piperidines was developed and applied to the synthesis of 1-(2-pyridinylmethyl)-piperidin-4-one, 1, a key starting material for the synthesis of LY317615, an
antiangiogenic agent
currently under development at Eli Lilly and Company (Chart 1).(1) The general utility of this methodology, which presents significant advantages over the classical Dieckman approach to this class of compounds, was also demonstrated by the direct synthesis of a series of substituted piperidones and piperidines, including potential
dopamine D4 receptor
antagonists 2 and 3, that have been evaluated in the clinic as antipsychotic agents (Chart 2).(2)
...
PMID:Green chemistry approach to the synthesis of N-substituted piperidones. 1283 73
