Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P39060 (
endostatin
)
2,284
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To investigate the correlation between normalization of
T cell receptor
(
TCR
) repertoire and remission of advanced colorectal cancer. Forty-one patients were randomly assigned to receive either folinic acid/fluorouracil/irinotecan alone (n = 20) or folinic acid/fluorouracil/irinotecan in combination with recombinant human
endostatin
(n = 21). Efficacy and toxicity were evaluated, and changes in
TCR
repertoire diversity were assessed by detecting the spectratypes of
TCR
complementarity-determining region three before and after several cycles of therapy. A scoring system was used to quantify changes in the
TCR
repertoire over time. The results demonstrated that the
TCR
repertoire exhibited a higher degree of normalization among patients undergoing remission relative to patients experiencing tumor progression. The results of the current study showed a positive correlation between
TCR
repertoire normalization and remission of colorectal cancer, suggesting that dynamic monitoring of
TCR
repertoire diversity may have potential prognostic value in the clinical setting.
...
PMID:Normalization of T cell receptor repertoire diversity in patients with advanced colorectal cancer who responded to chemotherapy. 2123 83
