Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P39060 (
endostatin
)
2,284
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A number of extracellular proteins contain cryptic inhibitors of angiogenesis. Endostatin is a 20 kDa C-terminal proteolytic fragment of
collagen XVIII
that potently inhibits endothelial cell proliferation and angiogenesis. Therapy of experimental cancer with
endostatin
leads to tumour dormancy and does not induce resistance. We have expressed recombinant mouse
endostatin
and determined its crystal structure at 1.5 A resolution. The structure reveals a compact fold distantly related to the
C-type lectin
carbohydrate recognition domain and the hyaluronan-binding Link module. The high affinity of
endostatin
for heparin is explained by the presence of an extensive basic patch formed by 11 arginine residues. Endostatin may inhibit angiogenesis by binding to the heparan sulphate proteoglycans involved in growth factor signalling.
...
PMID:Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution. 950 Oct 87
