Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P39060 (endostatin)
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AMP and HEDP complexation constants for seven divalent cations (Ca, Cu, Cd, Fe, Ni, Pb and Zn) have been determined by acid-base titrations at 25 +/- 0.5 degrees C, at constant ionic strength (0.1 M KNO(3)) with Martell and Motekaitis's computer programs. Speciation diagrams enable us to compare AMP, HEDP and TPP complexing properties. AMP complexes more strongly all seven divalent cations than HEDP and TPP, which have similar ligand behavior. Among the divalent cations studied here, the ligands have lowest affinity with calcium and usually higher with copper. In all the cation/ligand systems, the major species are ML and MHL which are charged species. The uncharged ionic species Ca(2)Y(0), CaH(4)X(0) and CdH(2)Y(0) (H(6)X = AMP and H(4)Y = HEDP) which can potentially exist in solid phase, cannot be neglected. Moreover hydroxide complexes have to be taken into consideration in the complexation constant determinations and in the environmental impact.
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PMID:Divalent cations speciation with three phosphonate ligands in the pH-range of natural waters. 1896 18

The complex formation constants of two phosphonic acids, HEDP and ATMP, with three trivalent metallic cations, Al(III), Cr(III) and Fe(III), have been determined by acid-base titration at 25 degrees C and constant ionic strength (0.1 mol l(-1), KNO(3)), using Martell and Motekaitis' computer programs. Species distribution curves showed that all three cations are in complex form in the pH range of fresh waters (5-9). The study of different cation/ligand ratios proved that both ligands mainly form anionic soluble complexes for systems having an excess of ligand-as protonated and unprotonated forms and especially ternary complexes with HEDP. For higher metal concentrations (excess of cation), weakly soluble species of HEDP and ATMP were formed with Al(III) and Cr(III). Two insoluble complexes with ATMP have been identified by SEM/EDAX as AlH(3)X((s)) and Cr(2)X((s)). Regarding Fe(III) species, Fe(OH)(3(s)) precipitate seems to predominate in solution.
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PMID:Complexation of trivalent cations (Al(III), Cr(III), Fe(III)) with two phosphonic acids in the pH range of fresh waters. 1896 24