Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P39060 (endostatin)
 2,284 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Endostatin is a well-known angiogenesis inhibitor. Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. Adipogenesis plays a critical role in controlling adipocyte cell number, body weight, and metabolic profile in a homeostatic state. Here we reveal that endostatin inhibits adipogenesis and dietary-induced obesity. The antiadipogenic mechanism of endostatin lies in its interaction with Sam68 RNA-binding protein in the nuclei of preadipocytes. This interaction competitively impairs the binding of Sam68 to intron 5 of mammalian target of rapamycin (mTOR), causing an error in mTOR transcript. This consequently decreases the expression of mTOR, results in decreased activities of the mTOR complex 1 pathway, and leads to defects in adipogenesis. Moreover, our findings demonstrate that the antiangiogenic function of endostatin also contributes to its obesity-inhibitory activity. Through the combined functions on adipogenesis and angiogenesis, endostatin prevents dietary-induced obesity and its related metabolic disorders, including insulin resistance, glucose intolerance, and hepatic steatosis. Thus, our findings reveal that endostatin has a potential application for antiobesity therapy and the prevention of obesity-related metabolic syndromes.
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PMID:Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis. 2610 92

Background- Endostatin by virtue of their therapeutic value against rheumatoid arthritis have recently generated enormous interest among biomedical science. Recent study revealed that various approaches have been made to prevent rheumatoid arthritis by either controlling or inhibiting the progression of angiogenesis. Objective- The main objective of the current manuscript is to enumerates the intrinsic role of endostatin in rheumatoid arthritis. Method- A thorough and detailed review of literature from the papers published from the year 1997-2019 was studied for preparation of the current article. Result- Endostatin is one such agent of subfamily of ECM called as multiplexins obtained from proteolytic cleavage of XVIII and its carboxylic terminal fragments and is known for its antiangiogenic and antiproliferative property. The exact mechanism of endostatin is still unclear but it acts by downregulating or inhibiting the responses of various factors including Id1, Id3, matrix metalloproteinase and Nuclear factor Kappa B that are liable for angiogenesis. The mutual effects on adipogenesis and angiogenesis, endostatin inhibits dietary induced obesity and its related metabolic disorders, such as insulin resistance, glucose intolerance and hepatic steatosis. Conclusion-The present review demonstrates the intrinsic usage of endostatin as a novel molecule in rheumatoid arthritis and focus on the status of the therapeutic potential of endostatin in inhibiting the activity of angiogenesis is also very well explored.
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PMID:Role Of Endostatin In Rheumatoid Arthritis. 3234 30