Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P39060 (endostatin)
 2,284 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The American Association for Cancer Research (AACR) meeting of this year highlighted the progress made with farnesyl transferase inhibitors; two compounds have now entered Phase I clinical trials: R 115777 (Janssen) and SCH 66336 (Schering Plough) and several others are nearing clinical testing. Several new protein kinase inhibitors from Warner Lambert and Novartis were also discussed. Angiogenesis (as well as apoptosis) also featured, with many pharmaceutical companies and academic institutions having programmes in this area of cancer research. The most promising second generation compounds are angiostatin/endostatin and inhibitors of tyrosine protein kinase from the vascular endothelial growth factor (VEGF) receptor, including SU 5416 which is in clinical trials.
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PMID:American Association for Cancer Research 1998: promises and prospects for the next century. 1599 13

Dimethylsulfide (CH(3)SCH(3)) is formed in anoxic freshwater sediments by biological methylation of methanethiol (CH(3)SH). We measured thiol methylation potential in low-pH, Sphagnum peat sediments from Alaska and Alabama by adding ethanethiol (CH(3)CH(2)SH) to peat slurries and quantifying the rate of ethylmethylsulfide (CH(3)CH(2)SCH(3)) formation. Thiol methylation potential ranged from 12 to 154 nM h(-1) and was significantly related to dimethylsulfide accumulation rates (P=0.0007; r(2)=0.48). Addition of methanol or syringic acid stimulated thiol methylation potential and dimethylsulfide accumulation rate, suggesting that these compounds could be methyl donors. Addition of acetate or its metabolic precursors (glucose or Sphagnum plant material) inhibited thiol methylation potential, but not carbon dioxide or methane production. Inhibition of methanogenesis with either 2-bromoethanesulfonic acid or KNO(3) consistently inhibited thiol methylation potential and dimethylsulfide accumulation. These results suggest that methanogens play a role in thiol methylation and therefore dimethylsulfide formation.
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PMID:Thiol methylation potential in anoxic, low-pH wetland sediments and its relationship with dimethylsulfide production and organic carbon cycling. 1971 41