Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P39060 (
endostatin
)
2,284
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Endostatin is an angiogenesis inhibitor that is an endogenously produced proteolytic fragment of
type XVIII collagen
. Although serum levels of
endostatin
have extensively been studied in patients with malignant diseases,
endostatin
in pleural effusion has not been fully evaluated. In order to determine whether
endostatin
is present in pleural effusion, and to determine whether
endostatin
levels vary in pleural effusion of different etiology, we measured levels of
endostatin
in 38 malignant pleural effusion due to lung cancer patients and 29 patients with non-malignant disease using an ELISA kit. Free form of
endostatin
was measurable (> 11.2 pg/ml) in 26 of 38 malignant and 13 of 29 non-malignant pleural effusion. Endostatin levels in the 38 malignant pleural effusion were significantly higher than those in patients with the 29 patients with non-malignant diseases ( p = 0.0131). However, there was not statistically significant difference between the patients with
pleuropneumonia
and those with tuberculous pleurisy ( p = 0.2194). In malignant pleural effusion due to lung cancer, the pleural effusion
endostatin
levels did not differ when the histological types of lung cancer were considered ( p = 0.0674). Endostatin was present in both malignant and non-malignant pleural effusion, and elevated levels of
endostatin
were observed in malignant pleural effusion. Although the mechanisms are unclear, elevated levels of
endostatin
in pleural effusion may represent the local productions of
endostatin
in pleural space.
...
PMID:Endostatin levels in exudative pleural effusions. 1474 37
