Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P33527 (
ABCC1
)
1,164
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
ABCC1
1164
ABCB1
407
P-glycoprotein
333
ABCG2
330
MRP1
320
multidrug resistance-associated protein
276
ATP-binding cassette
269
ATP
165
ABC
130
BCRP
120
ABCC2
118
MDR1
114
breast cancer resistance protein
107
Mol
106
ABC transporter
101
MRP2
99
Sep
90
P-gp
87
ATPase
75
GSH
75
multidrug resistance protein 1
73
MRP3
60
ABCC3
58
MRP4
47
ABCC4
45
MRP
38
ABCC5
34
MRP5
32
multidrug resistance protein
32
ABCC
32
ATP-binding cassette transporter
29
ABCC6
29
tyrosine kinase
27
polypeptide
23
xenobiotic
23
mdr1
23
ABCC10
21
ADR
21
p53
20
cytochrome P450
18
more...
Disease
cancer
428
tumor
202
GSH
75
breast cancer
64
leukemia
47
lung cancer
46
acute myeloid leukemia
38
carcinoma
34
MCF
32
colorectal cancer
26
hepatocellular carcinoma
25
ovarian cancer
20
adenocarcinoma
20
acute lymphoblastic leukemia
18
tumor growth
18
colon cancer
17
neuroblastoma
16
epithelial ovarian cancer
15
Leukemia
15
small cell lung cancer
14
melanoma
14
Alzheimer's disease
14
non-small cell lung cancer
14
lymphoma
13
gastric cancer
12
squamous cell carcinoma
12
CEM
12
acute promyelocytic leukemia
11
prostate cancer
11
chronic myeloid leukemia
11
tumorigenesis
10
tumor progression
10
lung carcinoma
10
pseudoxanthoma elasticum
10
epilepsy
9
neutropenia
9
metastases
8
multiple myeloma
8
HIV
8
carcinogenesis
8
more...
Symptom
diarrhea
3
seizures
2
starvation
1
asthenia
1
pain
1
spasticity
1
memory loss
1
hypothermia
1
hepatomegaly
1
bitter taste
1
splenomegaly
1
nausea and vomiting
1
Decreased activity
1
Drug
ABC
130
ADR
21
Glutathione
12
CPT-11
10
Adriamycin
9
Dermatol
5
CSF
5
ADM
4
Cremophor EL
4
ROS
4
Taxol
4
VCR
4
VCR
4
Adenosine triphosphate
4
Gleevec
4
Arsenic trioxide
4
Asthma
2
Mutagen
2
Imatinib
2
Bortezomib
2
Sunitinib malate
2
PMEA
2
Docetaxel
2
Ouabain
2
Gefitinib
2
Irinotecan
2
lysine
2
DM1
2
Etoposide
2
Hectorol
1
AZT
1
GEO
1
Monit
1
ascorbate
1
Portal
1
balanced salt solution
1
EPI
1
AraC
1
Leaf
1
Fluorescein
1
more...
Enzyme
P-glycoprotein
335
ATPase
75
MDR
35
topoisomerase
29
glutathione S-transferase
27
topoisomerase
25
ERK
22
luciferase
19
CYP3A4
17
reverse transcriptase
15
focal adhesion kinase
14
mitogen-activated protein kinase
13
gamma-glutamylcysteine synthetase
10
RNase
9
RNase
9
protein kinase
9
caspase-3
8
UDP-glucuronosyltransferase
7
thymidylate synthase
6
phosphodiesterase
5
phosphatidylinositol 3-kinase
5
deoxycytidine kinase
5
lactate dehydrogenase
5
catalase
5
RNA polymerase
4
transcriptase
4
glyceraldehyde-3-phosphate dehydrogenase
4
ACS
4
trypsin
4
LTA4 hydrolase
4
protein kinase C
4
glutathione reductase
4
glutathione peroxidase
4
folylpolyglutamate synthetase
3
PARP
3
sphingosine kinase
3
dihydropyrimidine dehydrogenase
3
NQO1
3
dihydropyrimidine dehydrogenase
3
IKK
3
more...
Compound
ATP
165
Dec
89
GSH
80
GSH
80
DNA
79
MTT
44
Clin
37
MDR
35
ADR
29
sulfate
29
SN-38
21
sodium
21
phosphate
19
oxygen
19
Adriamycin
18
VP-16
16
MDA
15
LTC4
15
bromide
13
cadmium
13
Hoechst 33342
12
alanine
11
water
11
DDP
11
Paclitaxel
10
diacetate
10
CPT-11
10
calcium
9
pyrene
8
GSSG
8
ADP
8
cysteine
8
potassium
8
ADP
8
ADP
8
Vinca
7
ABL
7
BCR
7
iron
6
Verapamil
6
more...