Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P33527 (
ABCC1
)
1,164
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Substrate and inhibitor properties of
H17
as novel modulator of transmembrane efflux pump activities have been characterized in an in situ absorption model. Poor substrate properties towards P-glycoprotein (P-gp) and
multidrug resistance-associated protein (MRP)
have been demonstrated. In competition with a MRP substrate
H17
proved to have strong MRP-inhibiting properties. The profile of a strong inhibitor with poor substrate properties makes
H17
a perspective hopeful candidate for effective therapies of transmembrane efflux pump activities.
...
PMID:Evaluation of substrate and inhibitor properties of a novel MDR modulator H17 towards transmembrane efflux pumps. 1875 72
