Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P33527 (
ABCC1
)
1,164
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Here we investigated the roles of
DARPP-32
in multidrug resistance (MDR) of gastric cancer cells and the possible underlying mechanisms. We constructed the eukaryotic expression vector of
DARPP-32
and transfected it into human vincristine-resistant gastric adenocarcinoma cell line SGC7901/VCR. Up-regulation of
DARPP-32
could significantly enhance the sensitivity of SGC7901/VCR cells towards vincristine, adriamycin, 5-fluorouracil and cisplatin, and could decrease the capacity of cells to efflux adriamycin. What's more, the results of subrenal capsule assay confirmed that
DARPP-32
might play a certain role in MDR of gastric cancer.
DARPP-32
could significantly down-regulate the expression of P-gp and zinc ribbon domain-containing 1 (ZNRD1), but not alter the expression of
multidrug resistance-associated protein (MRP)
or the glutathione S-transferase (GST).
DARPP-32
could also significantly decrease the anti-apoptotic activity of SGC7901/VCR cells. Further study of the biological functions of
DARPP-32
might be helpful for understanding the mechanisms of MDR in gastric cancer.
...
PMID:Reversal of multidrug resistance of vincristine-resistant gastric adenocarcinoma cells through up-regulation of DARPP-32. 1747 Apr 1
