Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UNIPROT:P31749 (AKT)
22,954 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein AKT 22954 PI3K 7483 mTOR 4378 ERK 2995 Mol 2804 MAPK 2051 ERK1 1697 PTEN 1635 insulin 1587 protein kinase B 1586 Sep 1364 caspase-3 1253 p53 1250 phosphatidylinositol 3-kinase 1094 Bcl-2 973 p38 955 MEK 926 phosphoinositide 3-kinase 857 EGFR 813 epidermal growth factor receptor 812 JNK 730 catenin 725 STAT3 710 tyrosine kinase 691 cytokine 582 TNF 562 extracellular signal-regulated kinase 562 vascular endothelial growth factor 530 cyclin D1 527 AKT1 523 PIK3CA 519 GSK 501 phosphatase 493 IL-6 482 VEGF 460 p21 444 HER2 441 PKB 435 E-cadherin 432 phosphatase and tensin homolog 420 PARP 416 AMPK 401 BRAF 367 IRS-1 360 ROS 359 ATP 348 collagen 344 STAT 344 receptor tyrosine kinase 343 KRAS 328 tumor necrosis factor 325 estrogen receptor 324 serine/threonine kinase 316 p65 304 PI3 303 RAF 301 LC3 296 rhabdomyosarcoma 295 p27 283 endoplasmic reticulum 282 EGF 282 insulin-like growth factor 280 caspase-9 279 FAK 275 MMP-9 274 matrix metalloproteinase 272 lipopolysaccharide 256 insulin receptor 250 CCK 248 MET 241 IGF-1 239 epidermal growth factor 238 S6K1 232 proteasome 231 annexin V 223 PKC 221 threonine 217 focal adhesion kinase 212 vimentin 208 MMP-2 205 more...

Disease cancer 8026 tumor 6137 breast cancer 1715 tumor growth 1685 tumorigenesis 1388 hepatocellular carcinoma 928 tumor progression 804 lung cancer 781 carcinoma 764 prostate cancer 723 carcinogenesis 651 colorectal cancer 629 melanoma 605 diabetes 582 non-small cell lung cancer 516 glioma 499 leukemia 495 adenocarcinoma 492 gastric cancer 472 ovarian cancer 432 metastases 398 MCF 389 squamous cell carcinoma 386 colon cancer 383 obesity 382 glioblastoma 366 pancreatic cancer 326 ischemia 294 lymphoma 285 acute myeloid leukemia 278 type 2 diabetes 270 B-cell lymphoma 245 Alzheimer's disease 240 liver cancer 235 osteosarcoma 233 multiple myeloma 212 endometrial cancer 181 hyperglycemia 179 cervical cancer 178 liver cancer 176 renal cell carcinoma 172 neuroblastoma 172 bladder cancer 164 aggressiveness 159 stroke 156 Hepatocellular carcinoma 155 tumor angiogenesis 151 epithelial ovarian cancer 150 atherosclerosis 144 glioblastoma multiforme 144 Parkinson's disease 143 EMT 138 chronic myeloid leukemia 129 heart failure 128 Blocking 128 lung carcinoma 125 thyroid cancer 125 sarcoma 121 DDP 118 hypertension 114 retinoblastoma 112 GSH 112 ATM 111 brain tumor 111 chronic lymphocytic leukemia 109 rheumatoid arthritis 106 osteoporosis 106 Melanoma 103 primary tumor 102 myocardial infarction 99 cerebral ischemia 92 skin cancer 92 Leukemia 92 depression 91 acute lymphoblastic leukemia 89 osteoarthritis 89 tuberous sclerosis 87 chronic lymphocytic leukemia 85 ABL 85 fatty liver 83 more...

Symptom starvation 127 pain 70 seizures 57 functional recovery 50 fatigue 32 diarrhea 27 exhaustion 25 cachexia 23 collapse 19 anesthesia 18 weakness 18 splenomegaly 17 memory loss 14 respiratory distress 13 overweight 11 ataxia 10 nausea 10 hyperoxia 9 hypothermia 8 pelvic pain 8 Scratch 7 skin damage 7 thinning 7 anorexia 6 vomiting 6 hepatomegaly 6 cough 5 low back pain 5 analgesia 5 dyspnea 5 acidity 4 acute stress 4 cancer pain 4 hypotonia 4 constipation 3 stomach pain 3 arthralgia 3 urinary frequency 3 wheezing 3 acute pain 3 abdominal pain 3 agitation 3 bone pain 2 Depressive symptoms 2 hypercapnia 2 incoordination 2 angina 2 dry eye 2 myalgia 2 skin irritation 2 knee pain 2 decreased appetite 2 bradykinesia 2 discomfort 2 chest pain 2 nausea and vomiting 2 discomfort 2 tremor 2 headache 2 back pain 2 ataxic gait 1 chronic constipation 1 ophthalmoplegia 1 finger pain 1 erythema 1 menopausal symptoms 1 leg pain 1 sore throat 1 chronic cough 1 hepatosplenomegaly 1 masculinization 1 Mucosal hyperplasia 1 difficulty with urination 1 Stiffness 1 swollen joints 1 musculoskeletal disability 1 Neuropathic pain 1 asthenia 1 cerebellar ataxia 1 neck pain 1 more...

Drug ROS 359 MAP 109 Monit 109 lysine 99 NVP 97 Dermatol 80 IL-2 71 Herceptin 69 Gefitinib 68 Sorafenib 66 Everolimus 50 Cetuximab 47 CSF 41 Imatinib 34 GEO 32 ICI 27 p75 26 uPA 26 Erlotinib 25 Cardiovasc 24 CAM 22 ABC 21 Dasatinib 20 Arsenic trioxide 20 EE2 18 Gleevec 18 Glucagon 18 Epigallocatechin 17 vitamin E 17 Bortezomib 17 ETS 17 ADR 16 Simvastatin 16 Taxol 16 NADH 15 Adriamycin 15 Glycyrrhiza 15 Angiotensin II 14 ascorbate 14 Emodin 13 TTC 13 Heme 13 Ethanol 13 Emodin 13 caffeine 12 Docetaxel 12 RAL 12 Retinoic acid 11 Bevacizumab 11 DM1 11 Parkin 11 CCL 11 Parkin 11 CTX 11 Rosiglitazone 11 PTC 11 ENT 10 Tarceva 10 Portal 10 Leaf 10 3-Methyladenine 10 RFP 10 Asthma 9 Gelatin 9 Estrogens 9 Activin 8 IFN-gamma 8 MRC 8 CTX 8 Indomethacin 8 Mutagen 8 TAK 8 DHT 8 DHT 8 CTX 8 CoCl2 7 G-CSF 7 CoCl2 7 Glutathione 7 Histamine 7 more...

Enzyme mitogen-activated protein kinase 4957 ERK 4790 focal adhesion kinase 1584 protein kinase 1331 MEK 1116 phosphatidylinositol 3-kinase 1094 caspase-3 884 phosphoinositide 3-kinase 857 luciferase 560 AMP-activated protein kinase 559 GSK 524 PARP 455 AMPK 408 AMPK 401 protein kinase C 350 proteasome 232 PDK1 223 superoxide dismutase 202 caspase-9 199 calcineurin 164 catalase 127 IKK 112 cdc2 105 caspase-8 99 ATPase 94 MAP 94 lactate dehydrogenase 91 NADPH oxidase 86 NADPH oxidase 80 alkaline phosphatase 77 protein phosphatase 2A 65 TOR 64 P-glycoprotein 60 peroxidase 58 alanine aminotransferase 55 urokinase-type plasminogen activator 53 phospholipase C 53 collagenase 52 MMP 52 phosphoenolpyruvate carboxykinase 50 glutathione S-transferase 50 aspartate aminotransferase 49 glutathione peroxidase 48 ACS 47 NO synthase 45 reverse transcriptase 44 phosphatidylinositol-4,5-bisphosphate 3-kinase 43 APC 42 thrombin 36 tyrosinase 35 HK2 33 phosphodiesterase 33 phosphoenolpyruvate carboxykinase 30 heme oxygenase 30 phosphoenolpyruvate carboxykinase 30 matrix metalloproteinase 2 30 glucose-6-phosphatase 28 MPP 27 topoisomerase 27 NQO1 27 acetyl-CoA carboxylase 26 creatine kinase 26 renin 26 NOS 26 CaMKII 25 inositol 3-kinase 25 topoisomerase 24 MEKK1 24 matrix metalloproteinase 9 24 MMP-3 23 RNA polymerase 23 glyceraldehyde-3-phosphate dehydrogenase 22 complex I 22 cathepsin K 21 AST 20 caspase-7 20 demethylase 20 caspase-7 20 PKG 18 DNA methyltransferase 18 more...

Compound DNA 1444 Dec 1421 glucose 1336 oxygen 1220 MEK 910 tyrosine 761 MTT 719 TNF 562 Clin 522 serine 466 MDA 433 calcium 390 threonine 373 ATP 348 methionine 336 Insulin 283 nitric oxide 247 water 243 phosphate 222 cAMP 217 sodium 178 hydrogen 156 cysteine 153 bromide 149 Phosphatidylinositol 141 TNM 135 DDP 133 Rapamycin 133 iodine 131 lysine 128 AMP 117 GSH 116 GSH 116 acetate 100 arginine 100 BCR 98 MAP 97 dUTP 97 Vimentin 96 glutamate 96 ethanol 94 N-acetylcysteine 91 ABL 86 H2O2 85 leucine 85 galactose 80 sulfate 79 ADP 75 alanine 74 boron 71 Metformin 70 Metformin 70 Curcumin 70 Resveratrol 69 GTP 69 THP 68 THP 68 retinoic acid 66 ADP 64 ADP 64 selenium 63 zinc 62 ADP-ribose 61 urea 61 NAD 61 nitrogen 55 Wortmannin 54 palmitic acid 54 Phe 53 5-FU 53 MTS 51 ASA 49 Melatonin 47 ADR 47 Cardiol 47 Adriamycin 46 ACS 46 ACS 46 Ang II 45 iron 45 more...

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