Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P31749 (AKT)
 22,954 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
AKT 22954
PI3K 7483
mTOR 4378
ERK 2995
Mol 2804
MAPK 2051
ERK1 1697
PTEN 1635
insulin 1587
protein kinase B 1586
Sep 1364
caspase-3 1253
p53 1250
phosphatidylinositol 3-kinase 1094
Bcl-2 973
p38 955
MEK 926
phosphoinositide 3-kinase 857
EGFR 813
epidermal growth factor receptor 812
JNK 730
catenin 725
STAT3 710
tyrosine kinase 691
cytokine 582
TNF 562
extracellular signal-regulated kinase 562
vascular endothelial growth factor 530
cyclin D1 527
AKT1 523
PIK3CA 519
GSK 501
phosphatase 493
IL-6 482
VEGF 460
p21 444
HER2 441
PKB 435
E-cadherin 432
phosphatase and tensin homolog 420
PARP 416
AMPK 401
BRAF 367
IRS-1 360
ROS 359
ATP 348
collagen 344
STAT 344
receptor tyrosine kinase 343
KRAS 328
tumor necrosis factor 325
estrogen receptor 324
serine/threonine kinase 316
p65 304
PI3 303
RAF 301
LC3 296
rhabdomyosarcoma 295
p27 283
EGF 282
endoplasmic reticulum 282
insulin-like growth factor 280
caspase-9 279
FAK 275
MMP-9 274
matrix metalloproteinase 272
lipopolysaccharide 256
insulin receptor 250
CCK 248
MET 241
IGF-1 239
epidermal growth factor 238
S6K1 232
proteasome 231
annexin V 223
PKC 221
threonine 217
focal adhesion kinase 212
vimentin 208
MMP-2 205
AKT2 204
c-Jun 204
proliferating cell nuclear antigen 203
osteosarcoma 201
CDK4 200
cytochrome c 196
Mcl-1 195
N-cadherin 194
VEGFR2 192
mitogen-activated protein 191
c-Myc 191
MEK1 190
ubiquitin 189
histone 187
CREB 184
4E-BP1 184
STAT5 183
chemokine 182
survivin 177
kit 176
AMP-activated protein kinase 176
CXCR4 174
androgen receptor 173
IL-8 170
p62 170
fibronectin 170
BAX 166
PDK1 166
UTR 165
MMP9 164
brain-derived neurotrophic factor 161
MYC 160
LPS 159
inducible nitric oxide synthase 159
JAK2 158
COX-2 158
extracellular signal-regulated kinase 1 157
BCL2 153
caspase-8 147
cage 146
PKA 145
Rho 143
ribosomal protein S6 142
Nrf2 142
Ki-67 142
BAD 141
4EBP1 141
tensin 141
p85 140
hepatocyte growth factor 140
Beclin-1 140
IFN 139
EMT 138
TLR4 138
P38 137
histone deacetylase 137
PC-3 136
interleukin-6 135
TNM 135
KIT 133
osteogenic 133
GSK3 132
erythroid 131
GLUT4 131
Cyclin D1 131
CD4 131
cyclin E 130
IL-10 130
EGF receptor 130
superoxide dismutase 127
eNOS 127
SRC 125
glucose transporter 125
FRAP 125
CD44 123
leptin 122
NRAS 121
signal transducer and activator of transcription 3 120
MAP kinase 120
CXCL12 118
more...
Disease
cancer 8026
tumor 6137
breast cancer 1715
tumor growth 1685
tumorigenesis 1388
hepatocellular carcinoma 928
tumor progression 804
lung cancer 781
carcinoma 764
prostate cancer 723
carcinogenesis 651
colorectal cancer 629
melanoma 605
diabetes 582
non-small cell lung cancer 516
glioma 499
leukemia 495
adenocarcinoma 492
gastric cancer 472
ovarian cancer 432
metastases 398
MCF 389
squamous cell carcinoma 386
colon cancer 383
obesity 382
glioblastoma 366
pancreatic cancer 326
ischemia 294
lymphoma 285
acute myeloid leukemia 278
type 2 diabetes 270
B-cell lymphoma 245
Alzheimer's disease 240
liver cancer 235
osteosarcoma 233
multiple myeloma 212
endometrial cancer 181
hyperglycemia 179
cervical cancer 178
liver cancer 176
renal cell carcinoma 172
neuroblastoma 172
bladder cancer 164
aggressiveness 159
stroke 156
Hepatocellular carcinoma 155
tumor angiogenesis 151
epithelial ovarian cancer 150
atherosclerosis 144
glioblastoma multiforme 144
Parkinson's disease 143
EMT 138
chronic myeloid leukemia 129
Blocking 128
heart failure 128
lung carcinoma 125
thyroid cancer 125
sarcoma 121
DDP 118
hypertension 114
GSH 112
retinoblastoma 112
ATM 111
brain tumor 111
chronic lymphocytic leukemia 109
rheumatoid arthritis 106
osteoporosis 106
Melanoma 103
primary tumor 102
myocardial infarction 99
cerebral ischemia 92
Leukemia 92
skin cancer 92
depression 91
osteoarthritis 89
acute lymphoblastic leukemia 89
tuberous sclerosis 87
chronic lymphocytic leukemia 85
ABL 85
fatty liver 83
Glioblastoma 83
metastatic melanoma 79
esophageal cancer 77
glucose intolerance 73
Osteosarcoma 72
Osteosarcoma 72
metabolic syndrome 72
liver fibrosis 71
myocardial ischemia 71
SCID 71
tumor initiation 70
T-cell acute lymphoblastic leukemia 70
cardiovascular disease 69
HGF 69
esophageal cancer 68
cognitive impairment 66
Hodgkin's disease 65
AGS 64
metastatic breast cancer 64
hyperinsulinemia 63
asthma 63
colitis 61
mantle cell lymphoma 59
sepsis 59
uterus 58
sepsis 57
HIV 57
schizophrenia 57
NOD 56
diabetic nephropathy 56
infertility 55
HCC 55
solid tumor 54
rhabdomyosarcoma 54
leukemogenesis 53
epilepsy 53
thymoma 53
cold 52
hematologic malignancies 52
dysplasia 52
papillary thyroid cancer 52
MTS 50
hepatitis B 50
Epstein 50
infectious diseases 49
aggression 49
cirrhosis 48
Hippel 47
mammary tumor 47
arthritis 47
mesothelioma 47
medulloblastoma 46
virus infection 46
autoimmune disease 45
dementia 45
renal cancer 44
addiction 43
oral cancer 43
head and neck cancer 42
anemia 42
muscular atrophy 42
endometriosis 42
AS1 42
autism 40
Esophageal squamous cell carcinoma 40
FAS 39
Neuroblastoma 39
pulmonary fibrosis 39
Neuroblastoma 39
APC 38
renal disease 37
astrocytoma 36
Kaposi's sarcoma 36
mole 36
chronic obstructive pulmonary disease 36
stromal tumors 35
diabetic retinopathy 35
lung metastases 35
brain cancer 35
small cell lung cancer 34
more...
Symptom
starvation 127
pain 70
seizures 57
functional recovery 50
fatigue 32
diarrhea 27
exhaustion 25
cachexia 23
collapse 19
weakness 18
anesthesia 18
splenomegaly 17
memory loss 14
respiratory distress 13
overweight 11
ataxia 10
nausea 10
hyperoxia 9
pelvic pain 8
hypothermia 8
Scratch 7
thinning 7
skin damage 7
anorexia 6
hepatomegaly 6
vomiting 6
cough 5
low back pain 5
dyspnea 5
analgesia 5
acidity 4
acute stress 4
cancer pain 4
hypotonia 4
constipation 3
stomach pain 3
arthralgia 3
wheezing 3
urinary frequency 3
acute pain 3
abdominal pain 3
agitation 3
bone pain 2
Depressive symptoms 2
hypercapnia 2
incoordination 2
dry eye 2
angina 2
myalgia 2
skin irritation 2
bradykinesia 2
knee pain 2
decreased appetite 2
discomfort 2
chest pain 2
nausea and vomiting 2
discomfort 2
tremor 2
headache 2
back pain 2
ataxic gait 1
chronic constipation 1
ophthalmoplegia 1
finger pain 1
erythema 1
menopausal symptoms 1
leg pain 1
sore throat 1
chronic cough 1
hepatosplenomegaly 1
masculinization 1
Mucosal hyperplasia 1
difficulty with urination 1
ENT 1
enuresis 1
Ill 1
swollen joints 1
despair 1
musculoskeletal disability 1
Neuropathic pain 1
asthenia 1
cerebellar ataxia 1
microbial colonization 1
Stiffness 1
neck pain 1
halitosis 1
tinnitus 1
chills 1
hemoptysis 1
spasticity 1
distraction 1
hot flashes 1
Motor dysfunction 1
epigastric pain 1
paraparesis 1
impaired motor coordination 1
Drug
ROS 359
Monit 109
MAP 109
lysine 99
NVP 97
Dermatol 80
IL-2 71
Herceptin 69
Gefitinib 68
Sorafenib 66
Everolimus 50
Cetuximab 47
CSF 41
Imatinib 34
GEO 32
ICI 27
uPA 26
p75 26
Erlotinib 25
Cardiovasc 24
CAM 22
ABC 21
Dasatinib 20
Arsenic trioxide 20
Glucagon 18
EE2 18
Gleevec 18
Epigallocatechin 17
ETS 17
Bortezomib 17
vitamin E 17
ADR 16
Simvastatin 16
Taxol 16
Adriamycin 15
NADH 15
Glycyrrhiza 15
ascorbate 14
Angiotensin II 14
Emodin 13
TTC 13
Ethanol 13
Heme 13
Emodin 13
caffeine 12
RAL 12
Docetaxel 12
Bevacizumab 11
CTX 11
Rosiglitazone 11
Parkin 11
PTC 11
CCL 11
DM1 11
Retinoic acid 11
Parkin 11
Portal 10
3-Methyladenine 10
ENT 10
Leaf 10
Tarceva 10
RFP 10
Estrogens 9
Asthma 9
Gelatin 9
Indomethacin 8
DHT 8
MRC 8
Mutagen 8
IFN-gamma 8
Activin 8
TAK 8
CTX 8
DHT 8
CTX 8
Histamine 7
Fructose 7
Liraglutide 7
CoCl2 7
CoCl2 7
Lovastatin 7
Glutathione 7
Pemetrexed 7
G-CSF 7
Etoposide 6
Casodex 6
Vandetanib 6
IL-11 6
TEL 6
Oxaliplatin 6
TAT 6
ALA 6
Myricetin 6
Propofol 6
PTH 6
Vorinostat 6
R1881 6
Ginseng 5
Aloe 5
Fluorescein 5
DEX 5
Donepezil 5
niacin 5
Kenyan 5
Romidepsin 5
Gel 5
ADM 5
KGF 5
Alanine 5
Spectrum 5
AMC 5
lactose 5
Troglitazone 5
CIA 4
Photofrin 4
Nitric Oxide 4
ROC 4
CPT-11 4
PDL 4
Retinoic Acid 4
Asn 4
G418 4
ACT 4
Pertuzumab 4
Luteinizing 4
Fragment 4
Bosutinib 4
Spectrum 4
Ranitidine 4
BLM 4
AraC 4
PFT 4
Fraction 4
Artesunate 4
Nephron 4
Isotretinoin 4
Doxycycline 3
Norplant 3
Fulvestrant 3
Triad 3
Capsicum 3
NLF 3
Alliance 3
Itraconazole 3
Sesamol 3
Irinotecan 3
Zoledronic acid 3
Pirarubicin 3
CTC 3
Safflower 3
Vinpocetine 3
Swainsonine 3
MDM 3
Nexavar 3
Orphan 3
Forskolin 3
PCB 3
NOV 3
Tykerb 3
ETA 3
more...
Enzyme
mitogen-activated protein kinase 4957
ERK 4790
focal adhesion kinase 1584
protein kinase 1331
MEK 1116
phosphatidylinositol 3-kinase 1094
caspase-3 884
phosphoinositide 3-kinase 857
luciferase 560
AMP-activated protein kinase 559
GSK 524
PARP 455
AMPK 408
AMPK 401
protein kinase C 350
proteasome 232
PDK1 223
superoxide dismutase 202
caspase-9 199
calcineurin 164
catalase 127
IKK 112
cdc2 105
caspase-8 99
MAP 94
ATPase 94
lactate dehydrogenase 91
NADPH oxidase 86
NADPH oxidase 80
alkaline phosphatase 77
protein phosphatase 2A 65
TOR 64
P-glycoprotein 60
peroxidase 58
alanine aminotransferase 55
urokinase-type plasminogen activator 53
phospholipase C 53
MMP 52
collagenase 52
phosphoenolpyruvate carboxykinase 50
glutathione S-transferase 50
aspartate aminotransferase 49
glutathione peroxidase 48
ACS 47
NO synthase 45
reverse transcriptase 44
phosphatidylinositol-4,5-bisphosphate 3-kinase 43
APC 42
thrombin 36
tyrosinase 35
phosphodiesterase 33
HK2 33
heme oxygenase 30
matrix metalloproteinase 2 30
phosphoenolpyruvate carboxykinase 30
phosphoenolpyruvate carboxykinase 30
glucose-6-phosphatase 28
topoisomerase 27
NQO1 27
MPP 27
NOS 26
creatine kinase 26
renin 26
acetyl-CoA carboxylase 26
CaMKII 25
inositol 3-kinase 25
topoisomerase 24
MEKK1 24
matrix metalloproteinase 9 24
MMP-3 23
RNA polymerase 23
glyceraldehyde-3-phosphate dehydrogenase 22
complex I 22
cathepsin K 21
demethylase 20
caspase-7 20
AST 20
caspase-7 20
DNA methyltransferase 18
adenylate cyclase 18
trypsin 18
PKG 18
tyrosine hydroxylase 18
hormone-sensitive lipase 18
CPT 17
prostate-specific antigen 17
arginase 17
DCF 17
granzyme B 16
polo-like kinase 1 16
STK11 16
sphingosine kinase 15
elastase 15
phospholipase A2 15
cathepsin B 15
aldehyde dehydrogenase 14
aldehyde dehydrogenase 14
pyruvate kinase 14
pyruvate dehydrogenase 13
glucokinase 13
aldehyde dehydrogenase 13
thioredoxin reductase 13
caspase-1 13
hexokinase 13
ACE 13
GRK2 13
AMP-activated kinase 13
aldehyde dehydrogenase 13
aldehyde dehydrogenase 13
kinesin 13
ALDH 13
pyruvate dehydrogenase 12
pyruvate dehydrogenase 12
lipase 12
ATP synthase 12
MIP 12
RNase 12
SPC 12
CPT 11
RNase 11
citrate synthase 11
CPT 11
histidine kinase 10
GRK5 10
TdT 10
triphosphatase 10
acetylcholinesterase 10
phosphofructokinase 9
thymidylate synthase 9
CAD 9
cathepsin D 9
enolase 9
ornithine decarboxylase 9
lipoprotein lipase 9
lysyl oxidase 9
CAD 9
CAD 9
CD13 8
neuraminidase 8
farnesyltransferase 8
CD10 8
glucose-6-phosphate dehydrogenase 8
farnesyltransferase 8
HSD 8
transcriptase 8
MDR 8
histone demethylase 8
PTPase 8
peroxiredoxin 8
furin 7
glyceraldehyde-3-phosphate dehydrogenase 7
beta-galactosidase 7
glyceraldehyde-3-phosphate dehydrogenase 7
phospholipase D 7
glyceraldehyde-3-phosphate dehydrogenase 7
carbonic anhydrase 7
gamma-glutamylcysteine synthetase 7
guanylate cyclase 7
thyroid peroxidase 7
glyceraldehyde-3-phosphate dehydrogenase 7
more...
Compound
DNA 1444
Dec 1421
glucose 1336
oxygen 1220
MEK 910
tyrosine 761
MTT 719
TNF 562
Clin 522
serine 466
MDA 433
calcium 390
threonine 373
ATP 348
methionine 336
Insulin 283
nitric oxide 247
water 243
phosphate 222
cAMP 217
sodium 178
hydrogen 156
cysteine 153
bromide 149
Phosphatidylinositol 141
TNM 135
DDP 133
Rapamycin 133
iodine 131
lysine 128
AMP 117
GSH 116
GSH 116
arginine 100
acetate 100
BCR 98
dUTP 97
MAP 97
glutamate 96
Vimentin 96
ethanol 94
N-acetylcysteine 91
ABL 86
leucine 85
H2O2 85
galactose 80
sulfate 79
ADP 75
alanine 74
boron 71
Metformin 70
Metformin 70
Curcumin 70
Resveratrol 69
GTP 69
THP 68
THP 68
retinoic acid 66
ADP 64
ADP 64
selenium 63
zinc 62
urea 61
NAD 61
ADP-ribose 61
nitrogen 55
palmitic acid 54
Wortmannin 54
Phe 53
5-FU 53
MTS 51
ASA 49
Melatonin 47
Cardiol 47
ADR 47
ACS 46
Adriamycin 46
ACS 46
iron 45
Ang II 45
salt 44
NH2 44
pyrimidine 43
acridine 42
pyrimidine 41
Asp 41
NAD 41
cadmium 41
PGE 40
nicotinamide 40
Estrogen 39
STZ 39
palmitic acid 39
Estrogen 39
cGMP 38
creatinine 38
Serine 38
Tamoxifen 37
Tamoxifen 37
PEG 36
PGE2 36
potassium 34
ALP 34
CAT 34
CAT 34
H2S 34
CAT 34
glutamine 34
kaempferol 33
Collagen 33
Quercetin 33
Tyrosine 32
TSC 32
NADPH 32
Panam 32
NADPH 32
Histone 31
diacetate 31
adenylate 29
DMSO 29
ethyl acetate 28
pyridine 28
5-HT 28
ICI 28
MPP 27
MPP 27
PEG 26
Neuronal 26
Pac 25
CAM 25
Glycogen synthase 24
titanium 24
proline 24
Thyroid 24
NMDA 24
Estradiol 24
Gly 23
MIA 23
TEM 23
Hematoxylin 23
Berberine 22
GABA 22
PMA 22
GABA 22
SCC 22
gallic acid 22
Luteolin 21
Angiotensin II 21
TTC 21
Cbl 21
silver 20
phenol 20
acetyl-CoA 20
Sphingosine 20
Celecoxib 19
tryptophan 19
anthracene 19
MPTP 19
Paclitaxel 19
GlcNAc 19
more...