Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P31749 (
AKT
)
22,954
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Platelets undergo apoptosis in response to a variety of stimuli in the circulation. Mitochondria in platelets are essential for their apoptosis. Specifically, pro-survival protein BCL-x
L
on mitochondria is the key regulator of platelet lifespan. Here we identify an outer mitochondrial membrane protein
FUNDC2
for platelet survival.
FUNDC2
knockout mice carrying excessively apoptotic platelets exhibit thrombocytopenia in response to hypoxia. Mechanistically,
FUNDC2
binds the lipid PIP3 via its unique, highly conserved N-terminal motif.
FUNDC2
deficiency abrogates the phosphorylation of
AKT
and its substrate BAD in a PIP3/PI3K-dependent manner, which suppresses BCL-x
L
. Indeed,
FUNDC2
deficiency shortens the platelet lifespan under stress. Thus, this
FUNDC2
/
AKT
/BCL-x
L
axis signifies a balance between platelet survival and apoptosis at the single organelle level and provides new insight for platelet-related diseases as well.
...
PMID:Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway. 2978 68
