Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P31749 (
AKT
)
22,954
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Brain and reproductive organ-expressed protein
(
BRE
) is aberrantly expressed in multiple cancers; however, its expression pattern in human esophageal squamous cell carcinoma (ESCC) and its role in ESCC progression remain unclear. In this study, we aimed to investigate the expression pattern of
BRE
in human ESCC and its role in ESCC progression.
BRE
was overexpressed in ESCC tissues compared with that in the adjacent non-tumor tissues. Forced expression of
BRE
was sufficient to enhance ESCC cell growth by promoting cell cycle progression and anti-apoptosis. Silencing of
BRE
suppressed these malignant phenotypes of ESCC cells. Mechanistic evaluation revealed that
BRE
overexpression activated the phosphorylation of
AKT
, and inhibition of the
AKT
pathway by MK2206 decreased the
BRE
-induced cell growth and apoptotic resistance in ESCC cells, highlighting the critical role of
AKT
signaling in mediating the effects of
BRE
. Moreover, the effects of
BRE
on ESCC cell growth and
AKT
activation were verified in a xenograft model
in vivo
. The present results show that
BRE
is overexpressed in ESCC tissues and contributes to the growth of ESCC cells by activating
AKT
signaling both
in vitro
and
in vivo
and provide insight into the role of
BRE
in
AKT
signaling and ESCC pathogenesis.
...
PMID:BRE Promotes Esophageal Squamous Cell Carcinoma Growth by Activating AKT Signaling. 3285 Apr 55
