Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P30536 (
PBS
)
9,886
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mice lacking
ApoA-V
, a novel HDL-associated apolipoprotein identified by our group and independently by Pennacchio et al. [Science 294 (2001) 169], were recently shown to be hypertriglyceridemic. To study the role of
ApoA-V
in triglyceride homeostasis, we compared lipid profiles in mice expressing normal and highly elevated levels of
ApoA-V
. For this purpose, adenoviral vectors expressing sense or antisense
ApoA-V
cDNA were constructed. Treatment of mice with sense adenoviral constructs resulted in circa 20-fold higher serum
ApoA-V
levels compared with mice injected with either
PBS
or antisense adenoviral constructs.
ApoA-V
overexpressing mice had markedly decreased (-70%) serum triglyceride levels caused primarily by lowered triglyceride content of the VLDL fraction. Furthermore, in these mice cholesterol levels were found to be lowered in all lipoprotein fractions with the largest mass decrease in the HDL fraction. This resulted in a 40% drop of serum cholesterol content. These findings suggest a role of
ApoA-V
in regulating levels of circulating triglycerides and cholesterol.
...
PMID:Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice. 1213 15
