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Query: UNIPROT:P30536 (PBS)
 9,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bioresorbable polymers have found a wide range of uses in medical implants, from sutures to scaffolds for tissue engineering applications. Increasingly they are being used in internal orthopaedic fixation devices, in which the strength retention profile is important. Polyglyconate B, a block co-polymer of glycolic acid and trimethylene carbonate, is one polymer used in these applications. In this study, the hydrolytic degradation of polyglyconate B has been studied in vitro. Specimens were prepared with two initial molecular weights and aged in PBS solution at 37 degrees C for up to 31 days. The polymers were characterised by gel permeation chromatography. for molecular weight, tensile testing and mass change, as a function of degradation time. A further aim of the work was to determine whether the measured changes in tensile strength over time could be fitted to a simple model. The results showed that the observed relationship between strength and molecular weight was more complex than that used in our model. However, the data could be modelled using an empirically derived relationship between tensile strength and number average molecular weight (Mn). Changes in other mechanical properties, such as strain at break, were also found to be strongly dependent on changes in the single parameter of Mn.
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PMID:Hydrolytic degradation of polyglyconate B: the relationship between degradation time, strength and molecular weight. 1216 96

Electrospun polyglyconate (Maxon) and its blends with proteins such as gelatin and elastin, with a spatially designed layer structure, were prepared as potential scaffolds for vascular tissue engineering. In vitro biodegradation of the electrospun tubular protein/Maxon scaffolds in phosphate buffered saline (pH = 7.3) was studied for the first time. The biodegradation is manifested by uptake of the PBS medium by the hydrophilic proteins and also by the mass loss due to the removal of degraded fragments and uncrosslinked proteins from the matrices. The effect of degradation on the structure-property relations was evaluated by IR, XRD, and DSC analyses of the aged scaffolds. The degradation of amorphous phase of Maxon in the early stages of aging has resulted in an increase in the crystallinity of the polymer. SEM analysis indicated a significant change in nanofiber morphology and fiber-breaking. The mass loss and fiber breaking have negatively impacted the mechanical properties and the effect was maximum at 15-20 days of aging. The scaffold containing low molecular weight buffer soluble elastin revealed relatively better degradation properties compared to that containing high molecular weight buffer insoluble elastin.
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PMID:In vitro biodegradation of designed tubular scaffolds of electrospun protein/polyglyconate blend fibers. 1878 Mar 60