Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P30536 (
PBS
)
9,886
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The potential of a mucoadhesive polymer as an ophthalmic vehicle is evaluated within the rabbit. Precorneal clearance of a mucoadhesive polymer solution (
Carbopol 934P
) is compared to that of an equiviscous nonmucoadhesive poly(vinyl alcohol) solution (PVA) and buffer (
PBS
). The precorneal retention of the
Carbopol 934P
, as studied by lacrimal dacryoscintigraphy, is shown to be significantly greater (P less than 0.05) than that of PVA, which, in turn, is significantly greater than that of
PBS
. The effect of the polymer solution on the bioavailability of pilocarpine is subsequently assessed by measuring the relative miotic response intensities produced by a 1% solution of the drug.
Carbopol 934P
solution produces a significant increase (P less than 0.05) in bioavailability as compared to PVA and
PBS
. The bioavailability from PVA is significantly greater (P less than 0.05) than that from
PBS
. Studies evaluating vehicle-drug association indicated no binding of the drug to the polymer.
...
PMID:Evaluation of mucoadhesive polymers in ocular drug delivery. I. Viscous solutions. 192 57
