Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P30536 (PBS)
 9,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum antibodies to human serum albumin (HSA) and its receptor structures (pre-S2) on HBV/HBsAg particles of IgG class were measured in patients with naturally acquired immunity to hepatitis B, HBsAg carriers with chronic liver disease, 'healthy' symptomless HBsAg carriers and controls. ELISA systems in which serum samples were diluted in 0.05 M PBS to give low protein concentrations followed by incubation at 4 degrees C were used. Anti-HSA and anti-pre-S2 were produced in patients during the acute phase of hepatitis B infection but were short-lived. The antibodies were absent in 'healthy' symptomless HBsAg carriers but present in the majority of HBsAg carriers with major liver disease. These results indicate that humoral immune responses of IgG class, normally initiated during the acute phase of HBV infection against the host 'self'-component HSA and/or its receptor structures, are down-regulated by immunological mechanisms while continuous production of these antibodies is associated with the pathogenesis of chronic HBV-induced liver disease.
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PMID:The immune response against pre-S2-encoded peptides and human serum albumin during hepatitis B virus infection. 368 44

Kinetics of binding of [3H]PK11195, an antagonist ligand with high selectivity for the peripheral-type (mitochondrial) benzodiazepine receptor (PTBR), was studied in homogenates of cerebral cortex, kidney, heart, and testis of portacaval shunted rats and sham-operated controls. Portacaval anastomosis resulted in a significant two- to threefold increase in the number of [3H]PK11195 binding sites in cerebral cortex and kidney. A reduction in the number of [3H]PK11195 binding sites was observed in testis preparations, while the number of binding sites in the heart remained unaltered. These differences in the response of PTBRs to portacaval anastomosis, in different organs suggest that the physiological function of these receptors and the factors regulating them are modulated by distinct mechanisms. The finding of increased densities of [3H]PK11195 binding sites in brain and kidney following portacaval anastomosis parallels the cellular hypertrophy in these tissues and, together with previous observations of similar increases of these binding sites in brain and kidney in congenital hyperammonemia, suggest a pathophysiologic role for ammonia in these changes. In contrast, the significant loss of [3H]PK11195 binding sites in testicular preparations following portacaval anastomosis together with the known effects of steroid hormones on these sites suggests a role for PTBRs in the pathogenesis of testicular atrophy in chronic liver disease.
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PMID:Tissue-specific alterations of binding sites for peripheral-type benzodiazepine receptor ligand [3H]PK11195 in rats following portacaval anastomosis. 817 18