Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P30536 (PBS)
 9,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Selection for reduced susceptibility to colibacillosis in broilers may contribute to the prevention of colibacillosis. Such selection should focus on the responses to Escherichia coli rather than the associated primary agent(s). The purpose of the current study was to examine whether genetic variation is present in the susceptibility to colibacillosis. This was achieved through an evaluation of the susceptibility to primary colibacillosis in 5 pure broiler lines, a slow-growing line, and two 2-way crosses of the pure lines (altogether referred to as genotypes). A challenge experiment was executed in 2 trials. Per trial, 24 chicks per genotype were challenged and 20 chicks per genotype were controls. At 7 d of age, challenged chicks were intratracheally inoculated with 0.3 mL of E. coli O78K80 solution, and controls with 0.3 mL of PBS. All chicks were euthanized at 14 or 15 d. Traits measured were mortality, lesion scores (airsacculitis, pericarditis, and perihepatitis) at 14 or 15 d, and BW at 1, 4, 7, 10, 12, and 14 or 15 d. An effect of genotype on mortality, lesion prevalence, and growth retardation was found, indicating the presence of genetic variation in susceptibility to colibacillosis, and suggesting that selection for reduced susceptibility is possible. There were large between-genotype differences in mortality (up to 46%) and in lesion prevalence (up to 41%). Growth retardation was not observed for any genotype in chicks without lesions, whereas genotypes differed from none to 20% growth retardation for chicks with airsacculitis but no systemic lesions, and up to 13% for chicks with systemic lesions. The heterosis in susceptibility and growth retardation was found to be either negative or absent, indicating that crossbreeding would not be an advantage for the selection for reduced susceptibility, and that test crossing is essential.
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PMID:Genetic variation among broiler genotypes in susceptibility to colibacillosis. 1655 69

Chagas' disease, endemic in Latin America, is spread in natural environments through animal reservoirs, including marsupials, mice and guinea pigs. Farms breeding guinea pigs for food are located in some Latin-American countries with consequent risk of digestive infection. The aim of this work was to study the effect of vaccination with Trypanosoma rangeli in guinea pigs challenged with Trypanosoma cruzi. Animals were vaccinated with fixated epimastigotes of T. rangeli, emulsified with saponin. Controls received only PBS. Before being challenged with T. cruzi, parasitemia, survival rates and histological studies were performed. The vaccinated guinea pigs revealed significantly lower parasitemia than controls (p<0.0001-0.01) and a discrete lymphomonocytic infiltrate in cardiac and skeletal muscles was present. In the chronic phase, the histological view was normal. In contrast, control group revealed amastigote nests and typical histopathological alterations compatible with chagasic myocarditis, endocarditis and pericarditis. These results, together with previous works in our laboratory, show that T. rangeli induces immunoprotection in three species of animals: mice, guinea pigs and dogs. The development of vaccines for use in animals, like domestic dogs and guinea pigs in captivity, opens up new opportunities for preventive tools, and could reduce the risk of infection with T. cruzi in the community.
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PMID:Vaccination with Trypanosoma rangeli induces resistance of guinea pigs to virulent Trypanosoma cruzi. 2427 40