Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P30536 (PBS)
 9,886 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Television programming covering disability over a ten year span, 1967-68 and 1977-78, was studied to determine similarities and differences. Variables identified for comparisons included network, program type, disability, time slot, and length of programming. The largest frequency of programs occurred on NBC in 1968. However, in 1978 the largest frequency occurred on the Public Broadcasting System. This can be partially explained by the increased numbers of programs on PBS overall and their traditional concern with public interest and service programming. The commercial networks historically have been in the business of entertaining and portray disability more so in that fashion. Movies head the list in 1968. However, in 1978, dramatic series and children's programming head the list followed by news documentaries and telethon. Paraplegia was the most frequent disability portrayed in 1968 followed by mental illness, drug addiction and emotional disability. In 1978 mental illness headed the list followed by alcoholism, emotional disability and physically handicapped. Paraplegia in 1968 can be accounted for by the program "Ironside" that featured a paraplegic detective. Mental illness and emotional disturbance seem to be consistent targets over the decade for popular programming in prime time.
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PMID:Television programming and disability: a ten year span. 645 Jan 85

Brain inflammation and paraplegia can be induced by an additional intraperitoneal (i.p.) and intracerebral (i.c.) restimulation in B6 mice after standard immunization with MBP in Freund's complete adjuvant (FCA) and Bordetella pertussis coadjuvant. Only the combination of i.p. MBP/FCA and i.c. MBP injection could induce clinical paraplegia; either one alone was not effective. Clinical symptoms would develop 2 days after the i.c. injection. The induction of paraplegia was MBP-specific, as irrelevant bovine serum albumin with the same protocol could not induce it. The i.p. restimulation was requisite and needed the MBP in FCA, as MBP in PBS was ineffective. Histopathological observation manifested cellular infiltration by leucocytes in perivascular spaces and cerebral cortex. Neutrophils were prominent at 12 h after i.c. injection, then were replaced by mononuclear cells 24 h later. There were dynamic changes in cell number and immunophenotype of VLA-4+ expression in cervical lymph node cells after i.c. injection. The cells derived from cervical lymph nodes had higher MBP-stimulated proliferation than that of distal lymph nodes. This additional i.p. and i.c. stimulation provides a new manipulation to study brain inflammation.
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PMID:Intracerebral injection of myelin basic protein (MBP) induces inflammation in brain and causes paraplegia in MBP-sensitized B6 mice. 921 35