Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P30044 (antioxidant enzyme)
 8,037 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study reports the effects of low level developmental Pb exposure on specific brain regions like hippocampus, cerebellum and cerebral hemispheres of antioxidant enzyme activities. Wistar dams were exposed to 50 ppm, 100 ppm and 500 ppm of Pb acetate in drinking water during pregnancy and lactation (gestation day 6 through PND 21 (post natal day) and activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) were determined in the hippocampus, cerebellum and cerebral hemispheres of pups during treatment period (PND 7, 14, and 21 days) and also during withdrawl period (PND 35, 45, 60 and 90 days). During treatment period, SOD activity significantly (p < 0.05) decreased in all regions of all the treated groups with maximum decrease in 500 ppm treated group of 21 days, while GSH-Px and GR activities increased with maximum increase in 21 days aged 500 ppm group. During withdrawl period, the activities of all enzymes were significantly (p < 0.05) reversed. Thus the perinatal exposure of dams to variable dosages of low level lead results in characteristic neurochemical alterations in rat brain regions due to impaired antioxidants function.
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PMID:Post natal antioxidant enzyme activity of rat brain regions during developmental lead exposure. 1771 80

Age related mitochondrial impairments are considered to be contributors of cardiovascular disease. This study was designed to examine whether early life exposure to lead (Pb) would lead to the Pb induced age related hematological and cardiac mitochondrial changes in rats, and to further examine the protective effect of nutrient metal mixture containing zinc, iron and calcium. Male albino rats were lactationally exposed to 0.2 % Pb-acetate or 0.2 % Pb-acetate together nutrient metal mixture (0.02 %) in drinking water of the mother from postnatal day 1 (PND1) to PND 21. The hemoglobin level, the activities of serum ceruloplasmin oxidase, cardiac mitochondrial enzymes catalase, manganese superoxide dismutase, copper zinc superoxide dismutase, glutathione peroxidase, succinate dehydrogenase, lipid peroxidation and Pb levels were analyzed at PND 45, 12 and 24 months age. The hematological parameters, and the cardiac TCA cycle and antioxidant enzyme markers and lipid peroxidation levels were significantly altered following Pb exposure in young rats (PND 45). These Pb induced changes persisted, though at much lower level in the aged rats. The Pb levels in blood and heart were also significantly higher in PND 45 and remained at detectable levels in older rats. The nutrient metal mixture containing iron, calcium and zinc significantly reversed these changes in all the chosen markers except lipid peroxidation in which the reversal effect was not significant. These data are supportive of age-related cardiac mitochondrial impairments and further provide evidence for the protective efficacy of nutrient metal mixture against Pb-toxicity.
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PMID:Lead-induced cardiac and hematological alterations in aging Wistar male rats: alleviating effects of nutrient metal mixture. 2253 43

Fetal and early childhood exposure to low levels of chemicals formed in foods during heating, especially acrylamide (ACR) is of increased concern due to developmental neurotoxicity. The neurodevelopment during perinatal period is critical and evidence suggests that the gut microbiota plays a major role in shaping brain development and behavior. Pregnant Wistar rats provided with oral supplements a combination of fructo- and xylo-oligosaccharides (FOS + XOS, 3 g/kg/day) from gestation day 0 (GD 0) to postnatal day 21 (PND 21) were exposed to ACR (100 ppm, GD 6 to PND 21) in drinking water. While ACR exposure caused a significant reduction in the maternal gestational/ lactational body weight, preweaning body weights and behavioral alterations among male offspring, combination supplement of FOS + XOS had no significant effect. However, significantly diminished antioxidant enzyme (SOD and CAT) activities in the maternal and offspring brain were restored among rats given FOS + XOS supplementation. The prebiotic supplementation normalized elevated nitric oxide levels in the cerebellum of the offspring born to ACR exposed rats. Furthermore, prebiotics restored the activity of acetylcholinesterase (AChE) and improved the levels of dopamine (DA) in the maternal cortex. The protective effect of prebiotic supplementation was also discernible in the mitochondrial fraction of maternal brain regions. These findings suggest that prebiotic supplementation during pregnancy may be useful in attenuating the perinatal toxic effects associated with neurotoxin exposure.
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PMID:Oral supplements of combined fructo- and xylo-oligosaccharides during perinatal period significantly offsets acrylamide-induced oxidative impairments and neurotoxicity in rats. 3068 31