Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P30044 (antioxidant enzyme)
 8,037 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Enantioselectivity in ecotoxicity and biodegradation of chiral pesticide benalaxyl to freshwater algae Scenedesmus obliquus was studied. The 96 h-EC(50) values of rac-, R-(-)-, S-(+)-benalaxyl were 2.893, 3.867, and 8.441 mg L(-1), respectively. Therefore, the acute toxicities of benalaxyl enantiomers were enantioselective. In addition, the pigments chlorophyll a and chlorophyll b, antioxidant enzyme activities catalase (CAT) and superoxide dismutase (SOD) as well as lipid peroxide malondialdehyde (MDA) were determined to evaluate the different toxic effects. Chlorophyll a was induced by S-(+)-benalaxyl but inhibited by R-(-)-benalaxyl at 1 mg L(-1). Chlorophyll b were both induced at 1 mg L(-1), but S-(+)-form was fourfold higher than R-(-)-form. S-(+)-benalaxyl inhibited more CAT activities at 3 mg L(-1) and 5 mg L(-1), induced less SOD activity and MDA content at 5 mg L(-1) than R-(-)-benalaxyl. Based on these data, enantioselectivity occurred in anti-oxidative stress when S. obliquus response to benalaxyl. In the biodegradation experiment, the half-lives of S-(+)-benalaxyl and R-(-)-benalaxyl were 4.07 d and 5.04 d, respectively, resulting in relative enrichment of the R-(-)-form. These results showed that toxic effects and biodegradation of benalaxyl in S. obliquus were enantioselective, and such enantiomeric differences must be taken into consideration in pesticide risk.
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PMID:Enantioselective toxic effects and biodegradation of benalaxyl in Scenedesmus obliquus. 2216 12