Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P30044 (antioxidant enzyme)
 8,037 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Aging is an inevitable biological process and characterized by a general decline in physiological function that leads to morbidity and mortality. Specific causes of this decline are not known. Rapid development in free radical biology and molecular technology has permitted the acquisition of data in support to the role of oxidative stress or injury as a major contributor to the aging process and to the pathogenesis of a number of diseases. Nevertheless, a direct link between oxidative stress and aging has not as yet been established. It is concluded that although there is considerable evidence implicating oxidative stress in the aging process, additional evidence is needed to clearly define the nature of the involvement. The present study has been designed to evaluate the age-related changes in rat liver by ESR method. The study was performed on 16 white male rats (4 newborns, 4 young, 4 adult and 4 senescent). Received data indicate that in white rats the aging is accompanied by slight increase in free radical production and significant decrease in antioxidant capacity of the liver cells. The present study suggests that accumulation of oxidized proteins during aging is most likely to be linked with an age-related decline of antioxidant enzyme activities.
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PMID:The ESR study of redox state of hepatocytes during aging in white rats. 1582 31

This study was designed to examine the antioxidant and free-radical scavenging activities of two Allium species, Allium roseum and Allium subhirsutum. This study reports the results concerning bulb, stalk and leaf antioxidant enzyme activities (superoxide dismutase, catalase, guaiacol peroxidase and glutathione peroxidase), quantities of malonyldialdehyde, (*)OH and O(2) (*-) radicals and total antioxidant capacity determined by the FRAP method. Scavenging activities were determined by ESR method. The total antioxidant capacity was the highest in the leaves of Allium roseum. Among the investigated organs the leaves exhibited the highest antioxidant activities in all investigated Allium species. The highest ESR (84.61%) scavenger activity was observed in the leaves of Allium roseum.
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PMID:Antioxidant and free-radical scavenging activities of Allium roseum and Allium subhirsutum. 1881 6

Paeoniae radix is a traditional Chinese medicinal herb for treating some diseases; important components are total paeony glycosides (TPGs), an approved drug by the State Food and Drug Administration (SFDA) for the therapy of rheumatoid arthritis (RA). We firstly reported myocardial benefits of TPGs previously, and the present study is to further investigate the underlying mechanisms for preventing oxidative damage in cardiomyopathy. We measured the capacity of TPGs to scavenge free radicals in vitro. Then 60 SD rats were randomly divided into five groups: (1) a normal control group, (2) an isoprenaline (ISO)-induced myocardial ischemic model group, (3) a TPG treatment group (TPGs 269.4 mg/kg delivered by intragastric administration for 3 days before ISO administration and TPGs 449 mg/kg delivered for 3 days after ISO administration), (4) a TPG therapy group (TPGs 449 mg/kg delivered for 3 days after ISO administration), and (5) a positive control group (propranolol 15 mg/kg for 3 days after ISO administration). The ISO-induced myocardial ischemic model was established by subcutaneous injection of 1mg/kg/8h ISO (2 times). The activities of myocardial enzymes, including glutamic oxaloacetic transaminase (GOT), creatine kinase (CK), lactate dehydrogenase (LDH), antioxidant enzyme superoxide dismutase (SOD) as well as the content of lipid peroxidation product malondialdehyde (MDA) were detected. We found that TPGs potently eliminated hydroxyl radicals and superoxide in vitro using ESR assays. Compared with model rats, TPG treatment, TPG therapy and the positive control treatment exhibited significantly reduced activities of GOT, LDH, and CK (p < 0.01), increased activity of SOD (p < 0.01) and lower levels of MDA (p < 0.05). More interestingly, the protective effect of TPG treatment was even better than that of propranolol. These results suggest that TPGs significantly ameliorate ISO-induced myocardial ischemia and their action might be through reducing oxidative stress in ischemic myocardium.
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PMID:Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. 2248 52