Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P30044 (antioxidant enzyme)
 8,037 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of copper deficiency on blood cholesterol and antioxidant defense mechanisms was investigated in male and female rats. Diets low in copper (Cu, 0.3 mg/kg) were given to a group of male (n = 5) and a group of female (n = 5), weanling Wistar rats for ten weeks. Diets containing adequate copper (Cu, 3.7 mg/kg) fed to another group of males (n = 5) and another group of females (n = 5) served as controls. Serum cholesterol levels and erythrocyte, granulocyte, lymphocyte and macrophage antioxidant enzyme activities were compared. Only copper deficient males showed increased serum cholesterol levels compared to controls. There were no significantly differences in erythrocyte measurements due to copper status, but males had significantly (P less than 0.05) higher haemoglobin levels, and erythrocyte catalase (CAT) and superoxide dismutase (SOD) activities than females. Low copper diets significantly decreased granulocyte SOD (P less than 0.01) in males, peritoneal macrophage SOD in females and lymphocyte SOD (P less than 0.05) in both sexes. Female controls had significantly (P less than 0.01) higher macrophage SOD than male controls and lymphocyte SOD was significantly higher in females. Results demonstrate sex differentiated effects of low copper diets on blood cholesterol and antioxidant defence mechanisms.
 ...
PMID:The effect of a low copper diet on blood cholesterol and enzymic antioxidant defense mechanisms in male and female rats. 324 99

Two distinct systems of different origin are involved in the pathogenesis of both infectious and immunological vasculitis syndrome: nitric oxide (NO) from endothelial cells and granulocyte NADPH oxidase. In this study, in 31 children with immune system dysfunction, NO, NO synthase (NOS) and antioxidant enzyme activities [catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx)], as well as immunological parameters, were investigated. On the basis of the clinical findings, all children were divided into three groups: group I, 8 children clinically showing macular skin manifestations; group II, 11 children with maculo-papulous changes; and group III, 12 children with clinical findings of papulous changes. Plasma NO values in groups II and III were significantly elevated (79.14+/-30.13 and 65.32+/-6.70 micromol/l), compared to the control group (41.24+/-3.65 micromol/l), while group I showed statistically lower values (32.38+/-3.37 micromol/l). In children with the highest level of NO (group II) NOS activity was two-fold higher (1.77+/-0.59 nmol/ml/min; p<0.01) than in controls (0.98+/-0.23 nmol/ml/min). Catalase activity showed a significant increase and SOD activity a significant decrease in all experimental groups, while GPx was not significantly changed. The results show that immune system dysfunction manifested as vasculitis is associated with significant disturbances in the NO system and free radicals scavengers.
 ...
PMID:Immune system-mediated endothelial damage is associated with NO and antioxidant system disorders. 1555 69