Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P30044 (antioxidant enzyme)
 8,037 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study was designed to examine the therapeutic potential of Terminalia arjuna bark extract in improving cardiovascular autonomic neuropathy in Streptozotocin (STZ)-induced diabetic Wistar Albino rats. The baroreflex was evaluated by measuring the changes in heart rate with changes in arterial blood pressure induced by bolus injections of phenylephrine (vasoconstrictor) and sodium nitroprusside (vasodilator). T. arjuna bark extract, Rosuvastatin and Insulin were tested/administered therapeutically in rat model of uncontrolled diabetes. After 8 weeks of STZ administration, the reflex bradycardia and tachycardia response to hypertension and hypotension, respectively, were impaired in the diabetic group. The reflex bradycardia improved significantly after 1 month treatment of T. arjuna while the reflex tachycardia could not improve. The decreased body weight, heart rate, blood pressure and raised blood sugar in diabetic rats were not improved by T. arjuna therapy. Rosuvastatin treatment exerted similar effects while Insulin improved all the parameters. Further T. arjuna, Rosuvastatin and Insulin significantly reduced oxidative stress and inflammatory cytokine levels in diabetic rats. Results suggest that T. arjuna bark extract improves the altered baroreflex sensitivity in diabetic rats possibly through maintaining endogenous antioxidant enzyme activities and decreasing cytokine levels.
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PMID:Terminalia arjuna improves cardiovascular autonomic neuropathy in streptozotocin-induced diabetic rats. 2300 77

Glutathione S-transferase (GST), as antioxidant enzyme, protects tissue from oxidative damage typical for many pathologic conditions as type 1 diabetes (T1D) and its chronic complications. The aim of the study was to compare the prevalence of GST T1/M1 gene polymorphisms between diabetic adolescents with (CAN+) and without (CAN-) cardiovascular autonomic neuropathy. Forty-six subjects with T1D at the age 15-19 years were enrolled. CAN was diagnosed in 19 patients (41.3%) based on standard cardiovascular tests. GST M1 null genotype was more prevalent in CAN+subjects but this was not statistically significant (OR=1.889, 0.61-6.55, p>0.05). GST T1 wild genotype nearly 5-fold increased the risk of CAN (OR=4.952, 1.13-21.739, p<0.05). Regarding genotype combination, GST T1/M1 wild/null genotype was significantly more frequent in CAN+compared to the CAN- subjects (OR=3.96, 1.024-15.302, p<0.05). No significant difference was found in any biochemical parameters between CAN+and CAN- subgroups. Multivariable logistic regression showed that none of the biochemical parameters estimated was considered a risk factor for CAN, however GST T1 wild and GST T1/M1 wild/null represented a risk factor for CAN development (OR=2.227, 1.079-4.587, p<0.05 and OR=1.990, 1.026-3.859, p<0.05, respectively). GST T1 wild allele and GST T1/M1 wild/null genotype can be considered as risk factors for CAN in Slovak adolescents with T1D.
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PMID:The association between glutathione S-transferase T1 and M1 gene polymorphisms and cardiovascular autonomic neuropathy in Slovak adolescents with type 1 diabetes mellitus. 2302 98