Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P30044 (antioxidant enzyme)
 8,037 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

BACKGROUND: Cardiac dysfunction and tissue injury during endotoxemia may be caused by increased levels of oxygen free radicals. METHODS AND RESULTS: We therefore investigated the effects of endotoxic shock on cardiac function and contractility, plasma creatine kinase (CK) activity and lactate concentration, oxyradical-producing activity of polymorphonuclear leukocytes (PMNL-CL) and white blood corpuscles, antioxidant reserve (cardiac chemiluminescence [LV-CL]), antioxidant enzyme activity (superoxide dismutase, catalase, glutathione peroxidase), cardiac malondialdehyde (MDA) concentration, a lipid peroxidation product, and hemodynamics in the absence or presence of flaxseed treatment in anesthetized dogs. Flaxseed contains lignans that have antioxidant activites and inhibit platelet-activating factor (PAF). The dogs were assigned to three groups: group I, sham control; group II, endotoxin (ET) treated (5 mg/kg intravenously); group III, ET + flaxseed (2 gm/kg/day orally) for 6 days. ET produced a decrease in cardiac function and contractility and antioxidant enzyme levels, and an increase in cardiac MDA and LV-CL, PMNL-CL, and plasma CK and lactate. Pretreatment with flaxseed attenuated the ET-induced cardiac dysfunction and cellular damage. Protection was incomplete for cardiovascular function, plasma CK, and lactate. CONCLUSIONS: These results suggest that oxyradicals and/or PAF may be involved in the deterioration of cardiovascular function and cellular integrity during ET shock and that antioxidant and anti-PAF agents may be effective in the treatment of ET shock.
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PMID:Oxygen Free Radicals and Endotoxic Shock: Effect of Flaxseed. 1068 13

The pathophysiology of endotoxic shock is complex. This review emphasizes the role of reactive oxygen species (ROS) in the pathophysiology of endotoxic shock and the effectiveness of flaxseed in amelioration of the deleterious effects of endotoxic shock on the cardiovascular function and health of the tissue. Endotoxic shock is associated with reduction in the cardiac function measured by cardiac index and left ventricular work index, cardiac contractility measured by dp/dt (rate of change of left ventricular pressure development), dp/dt at CPIP/PAW, where CPIP is common peak isovolumetric pressure and PAW is pulmonary arterial wedge pressure, arterial pressure, and cellular damage measured by increased plasma creatine kinase and elevated plasma lactate. It is also accompanied by increases in the generation of ROS by polymorphonuclear leukocytes, and cardiac lipid peroxidation product malondialdehyde (MDA) (cardiac MDA) and reduction in antioxidant reserve and antioxidant enzyme activity. Dimethylthiourea an antioxidant, prevented/reduced the endotoxic shock-induced changes in the cardiac function and contractility, arterial pressure, ROS generated by polymorphonuclear leucocytes; MDA, antioxidant reserve and antioxidant enzyme activity of cardiac tissue, and cellular health. Flaxseed which has antioxidant component ameliorated the endotoxic shock-induced changes in the cardiac function and contractility, arterial pressure, oxidative stress parameters and cellular health. In conclusion, the data suggest that ROS may play a role in the pathophysiology of endotoxic shock and that flaxseed, an antioxidant may have a role in the treatment of endotoxic shock.
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PMID:Flaxseed and endotoxic shock. 2397 99