Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P30044 (
antioxidant enzyme
)
8,037
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Immunogenic, methionine copper-induced response had proven to be precedent in providing resistance against certain diseases in fish. This study allocates the fitness strategy for
Oreochromis niloticus
by introducing and incorporating the well-designed, stabilized, and biocompatible
N
-carbamoyl-methionine copper (
NCM
-Cu) as a Cu potent source in diet that enhances the bioavailability and fitness. The synchronized
NCM
-Cu complex was characterized by directing ultraviolet and visible spectrophotometry (UV-vis), Fourier-transform infrared (FTIR), X-ray diffractometry (XRD), thermogravimetric analysis (TGA), and single-crystal X-ray diffraction. Results revealed blue columnar crystalline,
NCM
-Cu complex with an empirical formula as C
12
H
30
CuN
4
O
10
S
2
. Anonymously, the overall growth performance of the fish remained unaltered with
NCM
-Cu adjunct feed.
NCM
-Cu significantly raised the Cu accumulation in the fish muscles, liver, gill, and intestine in contrast to the basic Cu-rich feed. The serum
antioxidant enzyme
activity elevated up to (ceruloplasmin: 19.38 U/L) and the lowest liver malondialdehyde (MDA) content (8.81 nmol/mg prot.) and triglyceride content (0.39 nmol/g prot.) were observed in the
NCM
-Cu group as compared to the basic Cu and CuSO
4
groups, suggesting that
NCM
-Cu promoted antioxidative responses and alleviated lipid peroxidation of
O. niloticus
. Overweening, the synthesized complex,
NCM
-Cu significantly regulated the expression levels of lysozyme, immunoglobulin M, complement 4, and complement 3 up to 10.93 U/mL, 0.72, 0.77, and 1.18 mg/mL in serum, respectively. Thus, such endorsed results reveal the preeminence of
NCM
-Cu-supplemented diet for the fitness in
O. niloticus
.
...
PMID:Synthesis and Efficacy of the
N
-carbamoyl-methionine Copper on the Growth Performance, Tissue Mineralization, Immunity, and Enzymatic Antioxidant Capacity of Nile tilapia (
Oreochromis niloticus
). 3292 17
