Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P23193 (transcription elongation factor)
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Human Gene/Protein
elongation factor RNA polymerase II 15.4
Bcd orf1 15.4
cyclin T1b 15.4
F-box protein 3 15.4
transcription elongation factor 15.4
CYCT1b 15.4
TCEA3 15.1
CycT2 15.0
HEXIM2 14.9
Cyclin T2 14.4
hSPT5 14.4
ZNF99 14.4
Fliz1 14.4
SUPT5H 14.4
TLCD1 14.4
pentatricopeptide repeat domain 3 14.4
PHD finger protein 3 14.4
ZNF354A 14.4
MFSD3 14.4
IWS1 protein 14.4
HEXIM1 14.4
SUPT4H 14.2
cyclin T2a 14.1
La-related protein 7 14.1
cyclin T1 14.0
cyclin T 13.9
cyclin T2 13.9
Cyclin T1 13.8
interacts with Spt6 13.8
ELL-associated factor 1 13.8
EIF3S10 13.8
TAT-SF1 13.8
ELL3 13.8
testis-specific bromodomain protein 13.8
IWS1 13.8
MePCE 13.7
Tat-SF1 13.5
TCEB3C 13.4
elongin A 13.4
GIN-1 13.4
LARP7 13.4
CLP-1 13.4
SPT4 13.3
AFF4 13.3
TFIIS 13.2
PJA2 13.1
KDELR3 13.1
ELL2 13.0
CDK9 13.0
cyclin K 13.0
GALNT8 12.8
JMJD7 12.8
CDC2-related kinase 12.8
C17orf96 12.8
Tec protein tyrosine kinase 12.8
CA150 12.8
MRPL11 12.8
SPT5 12.8
CHCHD7 12.7
CRSP70 12.7
NELF 12.7
EFG2 12.6
transcription elongation factor S-II 12.6
CCNT2 12.6
AF5q31 12.3
FAST kinase 12.2
Interleukin-20 12.2
RNA-binding protein 7 12.2
I309 12.1
1-8D 12.1
ZFP161 12.1
ARHGAP11A 12.1
JPH1 12.1
COBRA1 12.1
bromodomain protein 12.0
EAF1 12.0
SS18L1 11.9
CTK1 11.9
HOOK3 11.9
REF1 11.8
LAF4 11.8
EAF2 11.8
ELL 11.7
ribosomal protein L36 11.7
PCIF1 11.7
Negative elongation factor E 11.7
SFRS3 11.7
NELF-E 11.7
hMet 11.6
CTD kinase 11.6
MYO1C 11.6
SPN1 11.6
RTF1 11.6
Wolf-Hirschhorn syndrome candidate 1 11.6
STK19 11.6
DOM3Z 11.5
MED26 11.5
RPB9 11.4
JMJD5 11.4
pp21 11.4
CLP1 11.4
POLRMT 11.4
DHX30 11.3
HUB1 11.3
FLICE-associated huge protein 11.2
GJC1 11.2
NELF-B 11.2
SPT6 11.2
EIF4A2 11.2
NELF-A 11.2
UBXD8 11.1
ATP5H 11.1
GPAA1 11.1
Eaf3 11.1
CDK-activating kinase 11.1
elongin C 11.1
LIP3 11.1
AFF3 11.0
HMT1 11.0
Set9 11.0
TAK 10.9
AFF2 10.9
BRD4-NUT fusion 10.9
NGN 10.9
bromodomain-containing protein 4 10.9
PPM1G 10.9
THO2 10.8
p55CDC 10.8
AFF1 10.8
MLL/AF4 10.8
HNRNPL 10.8
PAF49 10.8
PCWH 10.8
GANP 10.6
TCERG1 10.6
Werner syndrome helicase 10.6
RNA polymerase II subunit 10.6
SFRS1 10.6
RECQ5 10.6
Ctr9 10.5
SMC6 10.5
nuclear protein in testis 10.5
SKI2 10.5
FMR2 10.5
RNA polymerase II 10.4
muscle specific gene 10.4
ELP4 10.4
Cullin-2 10.4
mTERF 10.4
CTIP2 10.4
CRADD 10.4
TTF2 10.4
EDG1 10.4
A190 10.4
Elongin B 10.3
GMPPB 10.3
DNM2 10.3
PPM1B 10.3
suppressor of variegation 3-9 homolog 1 10.3
Cyclin B2 10.3
more...
Disease
PPR2 12.9
Primordial dwarfism 12.5
PIE 9.3
NK-cell leukemia 8.9
FRAXE 8.4
Cockayne syndrome 7.5
CSB 7.4
CSB 7.3
BLS 7.3
Human immunodeficiency virus type 7.2
HP1 7.1
XPB 7.0
RP1 6.7
Papilloma 6.6
NS2 6.6
XPG 6.5
Recruitment 6.4
RDC 6.1
MCS 5.9
MCS 5.9
CAN 5.8
familial cancer 5.7
NPH 5.7
vaccinia 5.6
Hippel 5.6
orf 5.6
immunodeficiency 5.6
MEN1 5.5
LMS 5.5
Rhabdomyosarcoma 5.5
PIN 5.2
HIV 5.2
PIN 5.1
leukemogenesis 5.0
Pulmonary arterial hypertension 5.0
latent infection 4.7
African swine fever 4.6
AS1 4.5
subacute sclerosing panencephalitis 4.4
RSV infection 4.4
WRN 4.3
premature aging 4.3
lipodystrophy 4.3
blast crisis 4.1
ARC 4.1
adult T-cell leukemia/lymphoma 4.1
Merkel cell carcinoma 4.0
EIA 3.9
EMT 3.9
mimicry 3.9
xeroderma pigmentosum 3.9
tularemia 3.9
Esophagus 3.9
Esophagus 3.9
Shigella flexneri 3.8
Rous sarcoma 3.8
AAA 3.8
lymphocytic choriomeningitis 3.8
gastrointestinal disease 3.8
plasmacytoma 3.7
retinoblastoma 3.5
Leukemia 3.5
leukemia 3.4
toxic shock syndrome 3.4
CEM 3.4
childhood cancer 3.3
ATM 3.3
PHA 3.3
acute leukemia 3.2
polycystic kidney 3.2
tumorigenesis 3.2
leiomyosarcoma 3.2
T-cell lymphoma 3.1
acute myeloid leukemia 3.1
papilloma 3.1
bronchiolitis 3.1
adenoma 3.0
male infertility 3.0
chronic lymphocytic leukemia 3.0
B-cell lymphoma 3.0
AIDS 2.9
Burkitt's lymphoma 2.8
rhabdomyosarcoma 2.8
chronic myeloid leukemia 2.8
amyotrophic lateral sclerosis 2.8
Esophageal 2.7
Lupus 2.6
teratoma 2.6
Legionella 2.6
MCF 2.6
chronic lymphocytic leukemia 2.6
Epstein 2.4
muscular atrophy 2.4
virus infection 2.4
candidiasis 2.4
developmental delay 2.4
hematologic malignancies 2.4
periodontal disease 2.3
abdominal aortic aneurysm 2.3
dilated cardiomyopathy 2.2
herpes simplex 2.2
ovarian cancer 2.2
ICP 2.1
leprosy 2.1
cleft palate 2.0
acute lymphoblastic leukemia 2.0
haemophilia 2.0
ventricular hypertrophy 1.9
epithelial ovarian cancer 1.9
glucose intolerance 1.9
prostate cancer 1.9
brain tumor 1.8
dental caries 1.8
breast cancer 1.8
periodontitis 1.8
tumor progression 1.7
Huntington's disease 1.7
fatty liver 1.6
tumor growth 1.5
Mycoplasma 1.5
myelodysplastic syndrome 1.5
dengue 1.5
coronary artery disease 1.5
mental retardation 1.4
mental retardation 1.4
hyperlipidemia 1.4
worms 1.4
cerebral ischemia 1.3
fungal infection 1.3
adenocarcinoma 1.3
cancer 1.3
gastric cancer 1.3
glioblastoma 1.2
pulmonary hypertension 1.2
primary tumor 1.1
pancreatic cancer 1.1
tumor 1.0
carcinogenesis 1.0
systemic lupus erythematosus 1.0
lupus 0.9
renal cell carcinoma 0.9
chronic renal failure 0.9
hepatocellular carcinoma 0.9
heart failure 0.8
neuroblastoma 0.6
dementia 0.6
cytomegalovirus 0.6
thrombocytopenia 0.5
hepatitis 0.5
carcinoma 0.5
cold 0.5
fits 0.5
renal failure 0.4
hepatitis C 0.3
multiple myeloma 0.3
lymphoma 0.3
hepatitis B 0.2
atherosclerosis 0.2
renal disease -0.1
SDS -0.2
more...
Symptom
starvation 2.8
insomnia 2.0
functional recovery 1.7
collapse 0.6
seizures -0.9
Drug
Flavopiridol 11.2
Vorinostat 7.9
TAK 7.4
ID2 7.2
TAT 6.2
Alliance 5.0
Gleevec 4.9
Bortezomib 4.9
Norplant 4.6
Docetaxel 4.6
lysine 4.5
Imatinib 4.1
Alanine 4.0
MOF 3.9
MRC 3.7
Kenyan 3.6
G-CSF 3.0
DNase I 2.4
ROS 2.2
Asn 1.9
IFN-gamma 1.6
NADH 1.0
Enzyme
CTD kinase 11.4
acyl-CoA reductase 10.3
glucosamine-6-phosphate deaminase 9.3
RNA polymerase 8.9
GDP-mannose pyrophosphorylase 8.9
poly(A) polymerase 8.6
pseudouridine synthase 8.1
eEF2 kinase 7.5
methionine sulfoxide reductase 7.5
Lys4 7.0
cdc2 7.0
exoribonuclease 6.9
histone acetyltransferase 6.8
IscS 6.6
triphosphatase 6.4
SPT 6.3
TAT 6.2
PGM 5.9
polynucleotide phosphorylase 5.9
MCS 5.8
peptidyl-prolyl cis-trans isomerase 5.8
arginine deiminase 5.6
GRK2 5.6
SPT 5.6
TOR 4.9
IKK 4.7
glyceraldehyde-3-phosphate dehydrogenase 4.3
chaperonin 4.3
phosphoglycerate kinase 4.3
glyceraldehyde-3-phosphate dehydrogenase 4.3
glyceraldehyde-3-phosphate dehydrogenase 4.3
N-acetyltransferase 4.2
glyceraldehyde-3-phosphate dehydrogenase 4.2
RNase 4.1
protein kinase 4.0
peroxiredoxin 4.0
MDP 4.0
RNase 4.0
RNase H 4.0
glyceraldehyde-3-phosphate dehydrogenase 3.9
micrococcal nuclease 3.9
calcineurin 3.7
proteasome 3.6
nitrogenase 3.6
glutathione S-transferase 3.5
DNase 3.5
CAD 3.3
CAD 3.3
CAD 3.2
transcriptase 3.2
protein kinase C 3.1
deaminase 3.1
adenosine deaminase 3.1
adenosine deaminase 3.0
demethylase 3.0
DNA polymerase 2.9
ATPase 2.9
MEK 2.8
luciferase 2.8
ribonuclease 2.7
ribonuclease 2.7
lipoprotein lipase 2.6
urease 2.6
beta-galactosidase 2.6
mitogen-activated protein kinase 2.5
urease 2.5
succinate dehydrogenase 2.4
cytochrome oxidase 2.3
complex I 2.3
plasmin 2.3
alcohol dehydrogenase 2.2
lipase 2.2
monoamine oxidase 2.0
phosphatidylinositol 3-kinase 2.0
PARP 1.7
reverse transcriptase 1.4
endonuclease 1.2
phosphodiesterase 1.2
ERK 1.2
glutathione peroxidase 1.0
catalase 0.6
superoxide dismutase 0.6
renin 0.3
focal adhesion kinase -0.0
alkaline phosphatase -0.2
ACS -0.9
Compound
HKP 11.4
HMBA 11.1
Elbrus 11.0
DRB 9.9
Granulin 9.6
HMBA 9.5
K-40 9.3
TAR 9.2
Indirubin 8.5
Nitrite 8.3
CUE 7.9
1H-indazole 7.4
D-Serine 7.3
DMB 7.3
MSL 7.1
TBP 7.0
DMB 6.9
7-methylguanosine 6.8
TBP 6.8
APO 6.6
Berberine 6.1
RELA 5.9
CAN 5.6
acetamide 5.5
acetamide 5.5
TFE 5.2
Glycogen synthase 5.2
Ribavirin 5.1
TTS 5.0
PAP 5.0
Docetaxel 5.0
PIN 4.8
Actinomycin D 4.8
PAP 4.7
PAP 4.7
PAP 4.7
serine 4.6
cyclohexane 4.5
DMA 4.5
DMA 4.4
Phorbol 4.4
dATP 4.4
PNP 4.3
lysine 4.3
DMA 4.2
methyl methanesulfonate 4.2
threonine 4.1
chalcone 4.1
phosphoserine 4.1
Ubiquitin 4.0
Alanine 4.0
40S 4.0
pyrimidine 3.9
pyrimidine 3.9
AAA 3.9
Serine 3.7
Rapamycin 3.7
tryptophan 3.6
5-FU 3.6
Cocaine 3.3
UTP 3.2
Guo 3.2
alanine 3.1
acetyl-CoA 3.0
His 2.9
arginine 2.9
ADP-ribose 2.9
TEM 2.9
COS 2.8
A 1 2.8
TRH 2.8
uridine 2.7
DNA 2.7
zinc 2.6
GTP 2.6
ATP 2.5
PMA 2.4
adenosylmethionine 2.3
alcohol dehydrogenase 2.3
TNF 2.3
ClO 2.3
leucine 2.1
Phe 2.1
Neuronal 1.9
tryptophan 1.9
tryptophan 1.9
tryptophan 1.8
asparagine 1.8
retinoic acid 1.8
PMA 1.8
cysteine 1.8
MEK 1.7
Off 1.7
tyrosine 1.6
Mg2+ 1.6
proline 1.4
chlorine 1.4
barium 1.4
Asp 1.3
boron 1.2
salt 1.2
PEG 1.1
pyrene 1.1
glycerol 1.1
TOF 1.1
Ile 1.0
AMP 1.0
NADH 1.0
MDA 0.8
glutamate 0.8
galactose 0.8
phosphate 0.8
glutamine 0.7
PEG 0.6
methionine 0.5
Gly 0.3
hydrogen 0.1
Dec -0.1
potassium -0.1
nitrogen -0.3
SDS -0.3
cAMP -0.4
oxygen -0.5
urea -0.6
iron -0.7
ACS -0.9
ACS -0.9
copper -1.1
water -1.4
ethanol -1.7
calcium -2.0
sodium -2.7
Clin -3.2