Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P23193 (
transcription elongation factor
)
739
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
One of the biggest group of proteins influenced by
protein kinase CK2
is formed by factors engaged in gene expression. Here we have reported recently identified yeast
transcription elongation factor
Elf1 as a new substrate for both monomeric and tetrameric forms of
CK2
. Elf1 serves as a substrate for both the recombinant CK2alpha' (K(m) 0.38 microM) and holoenzyme (K(m) 0.13 microM). By MALDI-MS we identified the two serine residues at positions 95 and 117 as the most probable in vitro phosphorylation sites. Coimmunoprecypitation experiments show that Elf1 interacts with catalytic (alpha and alpha') as well as regulatory (beta and beta') subunits of
CK2
. These data may help to elucidate the role of
protein kinase CK2
and Elf1 in the regulation of transcription elongation.
...
PMID:Yeast elf1 factor is phosphorylated and interacts with protein kinase CK2. 1675 61
