Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P21817 (RyR1)
 1,154 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
RyR1 1154
ryanodine receptor 417
RyR2 213
RyR3 132
RYR1 124
dihydropyridine receptor 106
calmodulin 79
Sep 76
Mol 74
cardiac muscle 69
endoplasmic reticulum 68
FKBP12 63
ATP 55
calcineurin 47
FK506 42
DHPR 35
ATPase 33
calcium channel 28
triadin 24
SERCA1 22
Gen 20
FK506-binding protein 18
fused 16
HEK 16
IP3R 15
FKBP 14
microsomal 13
PKA 12
NMR 12
STIM1 10
L-type calcium channel 10
Cav1.1 10
junctin 10
CACNA1S 10
AMP 9
S100A1 9
phosphatase 8
RYR2 8
muscle specific 8
non-muscle 8
calpain 8
SERCA2 7
insulin 7
RAD51 7
ASI 7
NER 7
IP3R1 7
glutathione S-transferase 6
GST 6
MTM1 6
MRI 6
prolyl isomerase 6
GSH 6
TRPC3 6
polypeptide 6
SEPN1 6
SPRY2 6
glutathione transferase 6
BRCA1 6
myotubularin 6
SDS 6
myosin heavy chain 5
CRAC 5
ROS 5
IP3R2 5
creatine kinase 5
FK506-binding protein 12 5
CCD 5
phospholamban 5
Ca2+-ATPase 5
DM1 5
NOX4 5
dystrophin 5
BRCA2 5
TOF 5
Triadin 5
PARP 5
TRPC1 5
STAC3 5
caspase-3 5
p50 4
insulin-like growth factor 4
acetylcholine receptor 4
SCR 4
JP1 4
calreticulin 4
FK-506 binding protein 4
membrane-bound 4
IP3R3 4
EF-hand domain 4
ADP 4
ADRB1 4
CREB 4
EF-2 4
renin 4
CASQ1 4
XRCC3 4
calsequestrin 1 4
CA1 4
all-trans 4
p53 4
membrane protein 4
cathepsin L 4
nitric oxide synthase 4
X-linked 4
CACNL1A3 4
Met 4
immunophilin 3
C-reactive protein 3
InsP3R1 3
alternatively spliced 3
Rad51 3
cardiac calsequestrin 3
BIN1 3
ANOVA 3
sarcomeric 3
cAMP-dependent protein kinase 3
JP2 3
SLN 3
Cathepsin L 3
Chk1 3
GSTM 3
RNS 3
parvalbumin 3
troponin I 3
DP1 3
Junctophilin-2 3
XRCC1 3
SPR 3
DMPK 3
IkappaBbeta 3
CIE 3
PKC 3
CPM 3
interacting protein 3
endonuclease 3
TDT 3
endothelin-1 3
sarcalumenin 3
TTN 3
IGF-1 3
PCP 3
IL-10 3
transforming growth factor-beta 3
hemoglobin 3
AMP-activated protein kinase 3
uncoupling protein 3
cytokine 3
adaptor protein 3
calpastatin 2
PARP1 2
voltage-gated potassium channel 2
NOX2 2
hole 2
histone 2
Bcl-2 2
CFP 2
ubiquitin 2
acetylcholinesterase 2
TRPC4 2
S100 2
tumor necrosis factor 2
dream 2
tyrosine kinase 2
NADPH 2
catalase 2
X-linked recessive 2
RNase 2
STAC 2
hinge 2
major histocompatibility complex 2
RFP 2
Chk2 2
SCN4A 2
TPC2 2
angiotensin II 2
MTMR14 2
DNA-dependent protein kinase 2
NCX1 2
myosin 2
brain-derived neurotrophic factor 2
desmin 2
sodium channel 2
natriuretic peptide 2
brain) 2
C10 2
dynamin 2 2
calmodulin 1 2
PCB 2
C-terminal peptide 2
interleukin-6 2
PMCA1 2
hOGG1 2
myoglobin 2
integral membrane protein 2
ATF 2
PP2A 2
threonine 2
XPD 2
HLA 2
EDL 2
IGF1R 2
reductase 2
myostatin 2
lactate dehydrogenase 2
atrogin-1 2
CA3 2
amphiphysin II 2
methyl CpG binding protein 2 2
IL-1 2
FMR1 2
V3-3 2
ASCT2 2
p47 2
CPT II 2
cytochrome P450 2
CASQ2 2
cholecystokinin 2
retinoic acid receptor 2
unknown function 2
cage 2
collagen 2
ATM 2
GSTO1 2
acid phosphatase 2
MIM 2
ERCC1 2
NOS1 2
DNM2 2
XPG 2
Ku70 2
ATR 2
MMR 2
DR3 2
PC3 2
prolactin 2
ACS 2
ITPR1 2
inward rectifier 2
FKBP1A 2
caveolin-3 2
TGF-beta 2
ABC 2
TPC1 2
plasma membrane calcium ATPase 2
SNARE 2
beta-endorphin 2
CO2 2
calcium pump 2
heterogeneous nuclear ribonucleoprotein 2
phosphodiesterase 2
MyoD 2
ACTH 2
titin 2
nicotinic acetylcholine receptor 2
SERCA3 2
cytochrome 2
chloride intracellular channel 1 1
proinsulin 1
CLIC1 1
UDPG 1
glycolytic enzyme 1
TRPV5 1
ADORA3 1
DRB1 1
HHH 1
Hepcidin 1
growth hormone 1
histone deacetylase 1
adenosine receptor 1
ERK1 1
LAMP 1
apelin 1
histone H2B 1
lipopolysaccharide 1
NAD 1
ACR 1
P28 1
FPR 1
enolase 1
muscarinic receptor 1
HPR 1
short-chain dehydrogenase/reductase 1
SK1 1
hexokinase 2 1
member 1 1
Dihydropyridine receptor 1
HDAC 1
non-functional 1
RPE 1
THP 1
glyceraldehyde 3-phosphate dehydrogenase 1
PTEN 1
alkaline ceramidase 2 1
cytochrome c oxidase 1
LGM 1
Notch3 1
MSH3 1
S100B 1
ZSWIM7 1
BCS 1
amphiphysin-like 1
fibrinogen 1
SOC 1
oxidoreductase 1
T cell receptor 1
smooth muscle myosin heavy chain 1
Junctophilin-1 1
SLCO1B1 1
ubiquitin-conjugating enzyme 1
splicing regulator 1
Dictyostelium 1
olfactory 1
Stac 1
IL-6 1
Titin 1
GSTA1-1 1
interleukin 6 1
APOC2 1
ATP synthase 1
more...
Disease
malignant hyperthermia 172
myopathy 77
heart failure 31
Central core disease 26
cancer 26
hypertension 14
diabetes 12
tumor 11
depression 10
centronuclear myopathy 9
cold 9
DM1 8
multicore 7
SDS 6
aggression 6
scoliosis 6
stroke 6
GSH 6
prolapse 5
ischemia 5
myocardial infarction 5
CCD 5
coronary artery disease 5
periodic paralysis 5
CCD 5
respiratory failure 4
cardiovascular disease 4
prostate cancer 4
SEM 4
Duchenne muscular dystrophy 4
tetanus 4
obesity 4
porcine stress syndrome 4
cardiomyopathy 4
muscular dystrophy 4
Alzheimer's disease 4
neuromuscular disorder 3
thymoma 3
mole 3
dysplasia 3
PCP 3
heart disease 3
tumor progression 3
nystagmus 3
Epstein 3
muscular atrophy 3
mole 3
ARVD 3
schizophrenia 3
akinesia 3
CIE 3
myasthenia gravis 3
leukemia 2
atherosclerosis 2
ATM 2
preeclampsia 2
colon cancer 2
status epilepticus 2
bone metastases 2
lung carcinoma 2
lung cancer 2
lymphopenia 2
congestive heart failure 2
breast cancer 2
pulmonary hypertension 2
aggressiveness 2
Catecholaminergic polymorphic ventricular tachycardia 2
terminal disease 2
anemia 2
strabismus 2
Dissociation 2
mental retardation 2
XPG 2
migraine 2
sepsis 2
Lambert-Eaton myasthenic syndrome 2
ovarian cancer 2
Still 2
mental retardation 2
epithelial ovarian cancer 2
Moore 2
achromatopsia 2
brucellosis 2
sepsis 2
uterus 2
fits 2
Rett syndrome 2
Best 2
hypertrophic cardiomyopathy 2
congenital disorder 2
glaucoma 2
confusion 2
coronary heart disease 2
genetic disorder 2
herpes simplex 2
insulinoma 2
ARVD2 2
obstructive sleep apnea 2
iron deficiency 1
vascular disease 1
amnesia 1
conduct disorder 1
Liver mass 1
Thymus 1
abdominal aortic aneurysm 1
SAR 1
Huntington's disease 1
Brugada syndrome 1
central serous retinopathy 1
myocardial ischemia 1
Fanconi 1
wasting 1
amyotrophic lateral sclerosis 1
oppositional defiant disorder 1
cerebral infarction 1
Blocking 1
FCU 1
graft-versus-host disease 1
leukoencephalopathy 1
DBA 1
essential hypertension 1
metabolic syndrome 1
carcinogenesis 1
adenocarcinoma 1
paramyotonia 1
idiopathic thrombocytopenic purpura 1
neuroblastoma 1
scotoma 1
proteinuria 1
lymphadenopathy 1
psychological stress 1
pathological fracture 1
multiple myeloma 1
CAM 1
retinitis pigmentosa 1
Adenovirus 1
PIC 1
AAA 1
hydrocephalus 1
sarcoma 1
Thymus 1
Parkinson's disease 1
lactic acidosis 1
XPF 1
bronchopulmonary dysplasia 1
congenital neuromuscular disorder 1
head and neck cancer 1
optic neuritis 1
MTS 1
unipolar depression 1
emotionality 1
xeroderma pigmentosum 1
NAME 1
mammary tumor 1
salmonellosis 1
facial palsy 1
carcinoma of the cervix 1
primary disorders 1
hemiplegic migraine 1
Chimera 1
gastric cancer 1
hemeralopia 1
PDD 1
addiction 1
SCT 1
bone disease 1
pituitary adenoma 1
developmental delay 1
BLM 1
dermatomyositis 1
psychological distress 1
gastroenteritis 1
immunodeficiency 1
Syndrome 1
myositis 1
craniosynostosis 1
cytomegalovirus 1
chronic pain 1
osteoporosis 1
pancreatic cancer 1
Leigh syndrome 1
Mitochondrial DNA depletion 1
sinus tachycardia 1
rickets 1
MIP 1
social stress 1
Cockayne syndrome 1
polymyositis 1
myopia 1
asthma 1
astigmatism 1
PBT 1
epilepsy 1
ocular hypertension 1
mimicry 1
Brown 1
hyperlipidemia 1
osteosarcoma 1
Testes 1
squamous cell carcinoma 1
hernia 1
skin cancer 1
extrapulmonary tuberculosis 1
metastases 1
lupus 1
erectile dysfunction 1
chronic obstructive pulmonary disease 1
TCP 1
autism 1
Lederer 1
BPS 1
ADHD 1
borderline personality disorder 1
autoimmune disease 1
hyperopia 1
acute lymphoblastic leukemia 1
dilated cardiomyopathy 1
childhood ALL 1
Congenital heart disease 1
arteriopathy 1
rare disease 1
camptocormia 1
Lupus 1
intraocular pressure 1
metastatic breast cancer 1
BMD 1
respiratory disease 1
tumorigenesis 1
cerebral ischemia 1
open angle glaucoma 1
DDP 1
acute promyelocytic leukemia 1
delirium 1
lymphatic vessels 1
Thymus 1
HRA 1
systemic lupus erythematosus 1
HHH 1
EGC 1
metachromatic leukodystrophy 1
rhabdomyosarcoma 1
bladder cancer 1
familial Mediterranean fever 1
membranous nephropathy 1
Symptom
weakness 57
anesthesia 22
fatigue 19
ophthalmoplegia 14
hypotonia 13
pain 7
muscle rigidity 4
cachexia 3
exhaustion 3
myalgia 3
seizures 2
respiratory distress 2
photophobia 2
dyspnea 2
hypothermia 2
muscle stiffness 2
collapse 2
low back pain 2
analgesia 1
starvation 1
overweight 1
ataxia 1
chest pain 1
chills 1
asynergy 1
diarrhea 1
blurred vision 1
neck pain 1
nausea 1
thinning 1
HSA 1
paresis 1
headache 1
impaired motor coordination 1
Drug
caffeine 164
Cardiovasc 9
Vitamin A 7
Asn 5
ROS 5
DM1 5
K201 3
PCP 3
lysine 3
CPM 3
ABC 2
RFP 2
Triclosan 2
CaCl2 2
Alanine 2
PCB 2
all-trans-retinol 2
CaCl2 2
CaCl2 2
Spectrum 2
CoCl2 1
CTX 1
Dantrolene sodium 1
vitamin E 1
Saha 1
IL-2 1
Retinoic acid 1
CoCl2 1
RbCl 1
RbCl 1
Angiotensin II 1
Nephron 1
CTC 1
Fragment 1
nitroglycerin 1
Gel 1
CAM 1
VCR 1
Arsenic trioxide 1
NAG 1
Forskolin 1
EE2 1
CTC 1
Glutathione 1
ascorbate 1
Dermatol 1
EDR 1
Leaf 1
BLM 1
Enzyme
dihydropteridine reductase 35
ATPase 33
protein kinase 21
calcineurin 15
glutathione S-transferase 14
protein kinase C 6
PARP 6
trypsin 5
creatine kinase 5
AMPK 4
renin 4
cathepsin L 4
AMP-activated protein kinase 3
endonuclease 3
NADPH oxidase 3
RNase 3
calcium pump 3
PCP 3
caspase-3 3
CPM 3
RNase 3
reverse transcriptase 3
phospholipase C 3
NADPH oxidase 3
mitogen-activated protein kinase 3
protein phosphatase 2A 2
phosphodiesterase 2
ERK 2
catalase 2
NO synthase 2
ACS 2
NOS 2
acid phosphatase 2
acetylcholinesterase 2
CPT 2
lactate dehydrogenase 2
citrate synthase 1
m-calpain 1
acyl-CoA dehydrogenase 1
chloramphenicol acetyltransferase 1
S1 nuclease 1
calpain 3 1
ATP synthase 1
aequorin 1
TSR 1
complex I 1
adenosine deaminase 1
glyceraldehyde-3-phosphate dehydrogenase 1
phosphatidylinositol 3-kinase 1
MIP 1
ribonuclease 1
caspase-9 1
adenosine deaminase 1
enolase 1
proteasome 1
glyceraldehyde-3-phosphate dehydrogenase 1
succinate dehydrogenase 1
topoisomerase 1
carboxypeptidase A 1
CCS 1
AMPK 1
lipoprotein lipase 1
CAD 1
peroxidase 1
cathepsin D 1
aldolase 1
superoxide dismutase 1
CAD 1
topoisomerase 1
CAD 1
tyrosine hydroxylase 1
pyruvate kinase 1
hexokinase 1
CaMKII 1
PDK1 1
ribonuclease 1
inositol phosphatase 1
choline acetyltransferase 1
mu-calpain 1
adenosine kinase 1
Compound
calcium 496
caffeine 164
Ryanodine 102
Dec 83
DNA 71
ATP 55
oxygen 52
FK506 42
m-cresol 29
Mg2+ 27
cysteine 24
alanine 21
arginine 19
sodium 18
Dantrolene 18
Clin 18
water 15
threonine 14
nitric oxide 13
leucine 12
lysine 12
glutamate 11
phosphate 10
nitrogen 10
potassium 10
Cardiol 9
retinol 9
glucose 9
CO2 9
His 9
salt 9
AMP 9
Gly 8
GSH 7
ADP-ribose 7
GSH 7
Vitamin A 7
Ile 7
tyrosine 7
Asp 7
SDS 6
CHAPS 6
sulfate 6
NH2 6
serine 6
retinoic acid 6
MHS 5
TOF 5
methionine 5
pyrene 5
Nicotinic acid adenine dinucleotide phosphate 4
ADP 4
tryptophan 4
ADP 4
Ruthenium 4
tryptophan 4
ADP 4
hydrogen 4
Phe 4
Ins(1,4,5)P3 4
cAMP 4
Ruthenium 4
1-propanesulfonic acid 3
ethanol 3
PCP 3
aldehyde 3
hydroxide 3
MAK 3
NAD 3
tryptophan 3
manganese 3
tryptophan 3
N-acetylcysteine 3
TDT 3
Austin 3
aldehyde 3
fluorine 3
selenium 3
nickel 3
asparagine 3
isoleucine 2
benzene 2
piperidine 2
Cyclic ADP-ribose 2
Fluo-3 2
MDA 2
H2O2 2
cadmium 2
ATF 2
Nifedipine 2
Inositol 2
iron 2
Losartan 2
hexane 2
Rapamycin 2
NADPH 2
CaCl2 2
phenol 2
acetate 2
aspartic acid 2
noradrenaline 2
Vasopressin 2
ACS 2
Cholesterol 2
Ruthenium red 2
UTP 2
aspartic acid 2
piperidine 2
CMK 2
DIDS 2
ACTH 2
chloroform 2
glutamine 2
cGMP 2
aldosterone 2
ACh 2
aspartic acid 2
ACS 2
Triclosan 2
isoleucine 2
aluminum 2
Alanine 2
NADPH 2
proline 2
aspartic acid 2
acrylamide 2
DMSO 1
Calcitonin 1
DMD 1
octyl 1
pyrimidine 1
2-hydroxyethyl 1
butyl acetate 1
phenylphosphinic acid 1
Genistein 1
DBA 1
glutamic acid 1
APT 1
PLA 1
oxalate 1
2-hydroxyethyl 1
5-HT 1
ECS 1
TCP 1
PPD 1
ammonium 1
TMB 1
Capsaicin 1
Retinal 1
TNF 1
silver 1
CCP 1
GlcNAc 1
Zwittergent 3-14 1
Dantrolene sodium 1
CPA 1
Halothane 1
AICAR 1
DBI 1
naphthoquinone 1
CPA 1
2-hydroxyethyl 1
Arsenic 1
XPA 1
CAT 1
TGR 1
cobalt 1
DCL 1
MCA 1
CCl4 1
phosphorus 1
copper 1
Tamoxifen 1
2-hydroxyethyl 1
TCP 1
palmitoyl-CoA 1
Nicotinic acid adenine dinucleotide phosphate 1
2-hydroxyethyl 1
Coomassie Blue 1
Methamphetamine 1
LCR 1
MCA 1
vitamin D 1
CCS 1
Guo 1
CPA 1
CoA 1
methane 1
GTP 1
dUTP 1
Angiotensin II 1
BMC 1
SET 1
DBP 1
DSM 1
NADP 1
Lac 1
Sildenafil 1
Lead 1
Isoform 1
DBA 1
Biotin 1
urea 1
Ethylene 1
2-hydroxyethyl 1
HgCl2 1
Succinylcholine 1
HCP 1
TCP 1
Resveratrol 1
pyridine 1
octyl 1
ethyl acetate 1
MTS 1
MMC 1
N-acetyl-D-glucosamine 1
phenylphosphinic acid 1
ITP 1
N-(4-hydroxyphenyl)retinamide 1
Chlorpyrifos 1
DBP 1
NAD 1
octyl 1
Adrenal 1
Cysteine 1
CTX 1
Ryanodol 1
benzenesulfonic acid 1
Thapsigargin 1
DBA 1
Lactate 1
pyrimidine 1
Flux 1
nitrate 1
Phenylephrine 1
myricetin 1
AICAR 1
Procaine 1
dimethyl methylphosphonate 1
PPD 1
CAM 1
Tamoxifen 1
Droperidol 1
2-hydroxyethyl 1
Tetracaine 1
benzophenone 1
Forskolin 1
Thiopental 1
GSSG 1
Isoproterenol 1
FK520 1
Triton X-100 1
Estradiol 1
Magnolol 1
CPA 1
2-mercaptoethanol 1
XPA 1
Norepinephrine 1
TCP 1
Insulin 1
Statin 1
POPC 1
THP 1
glycerol 1
HCP 1
creatinine 1
BLM 1
silicon 1
EDS 1
vinyl acetate 1
chlorine 1
Lidocaine 1
DBI 1
Glutaraldehyde 1
THP 1
CAT 1
CAT 1
H2S 1
AAA 1
AF-2 1
Taurine 1
Guo 1
dATP 1
COS 1
acetaldehyde 1
isoxazole 1
Sodium 1
2-hydroxyethyl 1
propionic acid 1
Phosphatidylinositol 1
propionic acid 1