Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P21817 (RyR1)
 1,154 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
RyR1 14.8
VTSIP 14.8
RyR3 13.9
Chloride intracellular channel 2 13.8
SLC8A1 protein 13.8
Junctophilin-1 13.8
ZSWIM7 13.2
DHRS7C 13.2
dihydropyridine receptor alpha 1 subunit 13.2
V3-3 13.2
STAC3 12.8
Cav1.1 12.7
DHPR 12.6
RyR2 12.5
dihydropyridine receptor 12.3
STAC2 12.2
mitsugumin 29 11.9
Triadin 11.9
Junctophilin-2 11.9
calsequestrin 1 11.8
RYR1 11.8
Dihydropyridine receptor 11.8
ryanodine receptor 11.6
CACNL1A3 11.6
CASQ1 11.5
junctin 11.5
CACNA1S 11.5
amphiphysin-like 11.4
sarcalumenin 11.3
HFM1 11.3
FK506-binding protein 12 11.2
histidine-rich calcium-binding protein 11.1
CACNB1 11.1
MTCO2 11.1
SERCA1 11.0
STAC 10.9
calmodulin 1 10.9
FKBP12 10.9
Stac 10.8
TRIC-A 10.8
SPRY2 10.8
FKBP1A 10.7
MTMR14 10.7
Junctin 10.7
triadin 10.6
POLN 10.6
SEPN1 10.6
Chloride intracellular channel protein 1 10.5
TRIC-B 10.5
JP1 10.5
IP3R3 10.4
CLIC2 10.4
doublesex and mab-3 related transcription factor 1 10.3
fast skeletal muscle troponin I 10.3
RYR2 10.3
GT11 10.1
IP3R2 10.1
IP3R1 10.1
TRPC1 protein 9.9
ectonucleoside triphosphate diphosphohydrolase 1 9.9
A1BG 9.9
succinate dehydrogenase flavoprotein subunit 9.9
FK-506 binding protein 9.9
alkaline ceramidase 2 9.9
Calumenin 9.9
cardiac calsequestrin 9.9
MTM1 9.8
DDDD 9.8
FK506-binding protein 9.8
MYCBP2 9.8
ADORA3 9.8
amphiphysin II 9.7
SLC8A1 9.7
PR72 9.7
ITPR3 9.7
DNM2 9.7
FKBP 9.6
MYH14 9.6
TPC2 9.6
myotubularin 9.5
RRH 9.5
S100A1 9.4
HLA DQB1 9.4
mAKAP 9.4
MYL3 9.4
ITPR1 9.3
EF-hand domain 9.3
RYR3 9.3
JP2 9.3
IP3R 9.2
SLC22A8 9.2
snapin 9.1
chloride intracellular channel 1 9.1
plasma membrane calcium ATPase 9.1
ANKRD1 9.1
NER 9.1
actin-binding protein 280 9.1
GSTM 9.1
InsP3R1 9.0
LETM1 9.0
ASI 8.9
ADRB1 8.9
MYH8 8.9
GSTO1 8.8
SERCA3 8.8
SPRY1 8.7
D-X 8.7
AGGG 8.7
BIN1 8.7
Carboxypeptidase A 8.7
Lrp4 8.7
CASQ2 8.6
ADORA2B 8.6
SMMHC 8.5
caveolin 3 8.5
PRY 8.5
VDAC3 8.5
muscleblind-like 8.4
G72/G30 8.4
PMCA1 8.4
IkappaBbeta 8.4
TTN 8.3
SERCA2 8.3
GSTA1-1 8.3
calumenin 8.2
HHH 8.2
CLIC1 8.2
TPC1 8.2
BAH 8.2
FK506 8.1
ADORA2A 8.1
TRPC3 8.1
GSTA2 8.0
SCN4A 8.0
APOC2 8.0
IGFR1 8.0
Cathepsin L 8.0
MNF 8.0
SLCO1B3 7.9
CPT II 7.9
methyl CpG binding protein 2 7.9
EF-2 7.9
muscle specific 7.9
TDT 7.9
SSC1 7.9
alpha II 7.9
DEGS1 7.8
RING-finger protein 7.8
CUG-BP1 7.8
melastatin 2 7.8
alpha-adducin 7.8
STIM1 7.8
BCL3 7.8
XRCC3 7.8
PMCA4 7.8
selenoprotein W 7.7
PDK2 7.7
DBI 7.7
CAMKII 7.7
prolyl isomerase 7.7
more...
Disease
Central core disease 13.5
ARVD2 12.2
malignant hyperthermia 11.0
porcine stress syndrome 10.9
congenital neuromuscular disorder 10.8
centronuclear myopathy 9.8
Liver mass 9.5
hemeralopia 9.2
Mitochondrial DNA depletion 9.0
FCU 8.6
Catecholaminergic polymorphic ventricular tachycardia 8.5
HHH 8.4
multicore 8.4
Lederer 8.1
central serous retinopathy 8.0
myopathy 7.5
camptocormia 7.5
ARVD 7.3
achromatopsia 7.3
periodic paralysis 7.2
paramyotonia 7.1
terminal disease 7.0
XPG 6.9
primary disorders 6.7
EGC 6.5
HRA 6.5
Chimera 6.5
Lambert-Eaton myasthenic syndrome 6.5
neuromuscular disorder 6.0
BPS 5.8
PBT 5.7
DM1 5.7
XPF 5.7
hemiplegic migraine 5.6
CIE 5.4
Congenital heart disease 5.2
akinesia 5.2
congenital disorder 5.1
CCD 4.9
oppositional defiant disorder 4.8
CCD 4.8
Testes 4.8
PIC 4.7
hyperopia 4.7
Moore 4.6
extrapulmonary tuberculosis 4.6
Cockayne syndrome 4.6
unipolar depression 4.5
sinus tachycardia 4.4
metachromatic leukodystrophy 4.4
open angle glaucoma 4.3
PDD 4.3
scoliosis 4.3
muscular dystrophy 4.2
Leigh syndrome 4.2
Brugada syndrome 4.2
thymoma 4.1
Rett syndrome 4.1
pathological fracture 4.0
ocular hypertension 4.0
familial Mediterranean fever 3.9
arteriopathy 3.9
insulinoma 3.9
scotoma 3.9
carcinoma of the cervix 3.9
Dissociation 3.9
Duchenne muscular dystrophy 3.8
conduct disorder 3.7
SCT 3.6
leukoencephalopathy 3.6
heart failure 3.6
PCP 3.6
prolapse 3.6
lymphopenia 3.5
nystagmus 3.5
childhood ALL 3.5
Thymus 3.5
Thymus 3.5
Thymus 3.5
social stress 3.5
myasthenia gravis 3.5
muscular atrophy 3.4
optic neuritis 3.4
MTS 3.4
emotionality 3.2
xeroderma pigmentosum 3.2
AAA 3.2
BLM 3.2
membranous nephropathy 3.2
Adenovirus 3.1
tetanus 3.1
bone metastases 3.1
astigmatism 3.1
brucellosis 3.1
polymyositis 3.1
rickets 3.0
craniosynostosis 3.0
status epilepticus 2.9
TCP 2.9
hypertrophic cardiomyopathy 2.9
respiratory failure 2.9
pituitary adenoma 2.9
facial palsy 2.8
Fanconi 2.8
bronchopulmonary dysplasia 2.8
lymphatic vessels 2.8
lactic acidosis 2.7
dermatomyositis 2.7
BMD 2.7
borderline personality disorder 2.7
Still 2.7
genetic disorder 2.6
myositis 2.6
strabismus 2.6
aggression 2.5
salmonellosis 2.5
MIP 2.4
obstructive sleep apnea 2.4
retinitis pigmentosa 2.4
cardiomyopathy 2.4
myopia 2.4
DDP 2.4
amnesia 2.3
CAM 2.3
epithelial ovarian cancer 2.3
mimicry 2.3
mole 2.2
delirium 2.2
aggressiveness 2.2
rhabdomyosarcoma 2.2
psychological stress 2.1
GSH 2.1
ATM 2.1
mammary tumor 2.1
idiopathic thrombocytopenic purpura 2.0
Lupus 2.0
erectile dysfunction 2.0
mole 2.0
iron deficiency 1.9
preeclampsia 1.9
cerebral infarction 1.9
bone disease 1.9
SAR 1.9
metastatic breast cancer 1.8
acute promyelocytic leukemia 1.8
mental retardation 1.8
mental retardation 1.8
head and neck cancer 1.8
Epstein 1.8
wasting 1.8
developmental delay 1.8
psychological distress 1.7
SDS 1.7
migraine 1.7
abdominal aortic aneurysm 1.7
Best 1.6
coronary artery disease 1.6
ADHD 1.6
Blocking 1.6
dilated cardiomyopathy 1.6
more...
Symptom
impaired motor coordination 7.2
ophthalmoplegia 6.9
muscle rigidity 6.7
hypotonia 5.9
muscle stiffness 5.5
asynergy 5.4
weakness 5.4
photophobia 5.1
cachexia 3.9
blurred vision 3.7
myalgia 3.7
fatigue 3.3
HSA 3.2
neck pain 2.8
chills 2.7
exhaustion 2.6
low back pain 2.5
anesthesia 2.5
paresis 2.2
hypothermia 1.7
respiratory distress 1.5
thinning 1.3
dyspnea 1.0
collapse 0.9
ataxia 0.8
chest pain 0.7
nausea 0.2
starvation 0.1
overweight 0.1
analgesia -0.0
pain -0.4
seizures -0.5
headache -1.0
diarrhea -1.1
Drug
K201 11.3
Dantrolene sodium 8.0
caffeine 7.7
Saha 7.7
CPM 7.1
all-trans-retinol 7.1
RbCl 6.7
RbCl 6.7
DM1 6.4
EDR 6.4
Vitamin A 6.0
RFP 5.5
Triclosan 5.1
CTC 4.7
PCP 4.5
CoCl2 4.5
CoCl2 4.5
Arsenic trioxide 4.4
CTC 4.4
BLM 4.4
Alanine 4.3
VCR 4.1
PCB 3.7
NAG 3.7
Fragment 3.6
Asn 3.6
Forskolin 3.4
CaCl2 3.1
CaCl2 3.1
CaCl2 3.1
Retinoic acid 3.0
ROS 2.8
Spectrum 2.8
ABC 2.6
Angiotensin II 2.4
Glutathione 2.4
CAM 2.2
EE2 1.8
nitroglycerin 1.6
CTX 1.4
Gel 0.9
vitamin E 0.7
Nephron 0.6
lysine 0.5
Leaf 0.3
Cardiovasc 0.3
ascorbate 0.3
IL-2 -0.1
Dermatol -3.2
Enzyme
dihydropteridine reductase 11.2
TSR 7.3
CPM 6.9
inositol phosphatase 6.4
calcium pump 6.4
calpain 3 6.0
cathepsin L 5.8
CCS 5.5
mu-calpain 5.3
m-calpain 5.1
adenosine kinase 4.9
carboxypeptidase A 4.8
calcineurin 4.6
PCP 4.5
acyl-CoA dehydrogenase 4.3
aequorin 4.2
protein phosphatase 2A 4.2
glutathione S-transferase 4.1
ATPase 3.8
PDK1 3.6
PARP 3.6
CPT 3.6
AMPK 3.2
NADPH oxidase 3.0
aldolase 3.0
NOS 2.9
S1 nuclease 2.9
enolase 2.9
NADPH oxidase 2.9
creatine kinase 2.9
protein kinase 2.8
CaMKII 2.8
cathepsin D 2.7
AMP-activated protein kinase 2.7
CAD 2.7
CAD 2.6
citrate synthase 2.6
CAD 2.6
MIP 2.5
chloramphenicol acetyltransferase 2.4
adenosine deaminase 2.4
adenosine deaminase 2.4
pyruvate kinase 2.4
hexokinase 2.4
RNase 2.3
glyceraldehyde-3-phosphate dehydrogenase 2.3
RNase 2.2
phospholipase C 2.2
endonuclease 2.2
AMPK 2.1
choline acetyltransferase 2.1
acid phosphatase 2.1
glyceraldehyde-3-phosphate dehydrogenase 2.1
ribonuclease 2.1
ribonuclease 2.1
lipoprotein lipase 2.0
ATP synthase 2.0
caspase-9 1.9
NO synthase 1.8
succinate dehydrogenase 1.8
protein kinase C 1.7
trypsin 1.7
complex I 1.6
renin 1.6
topoisomerase 1.6
phosphodiesterase 1.6
topoisomerase 1.5
reverse transcriptase 1.4
phosphatidylinositol 3-kinase 1.3
caspase-3 1.2
acetylcholinesterase 1.0
lactate dehydrogenase 0.9
tyrosine hydroxylase 0.9
catalase -0.0
proteasome -0.1
mitogen-activated protein kinase -0.2
ACS -0.5
ERK -0.8
superoxide dismutase -1.1
peroxidase -1.2
Compound
Ryanodol 11.4
Ryanodine 11.4
phenylphosphinic acid 10.8
phenylphosphinic acid 10.8
m-cresol 10.3
Dantrolene 10.3
MHS 9.0
Zwittergent 3-14 8.8
FK520 8.4
Dantrolene sodium 8.2
1-propanesulfonic acid 8.0
TDT 8.0
caffeine 7.7
DBI 7.7
Nicotinic acid adenine dinucleotide phosphate 7.7
FK506 7.6
Cyclic ADP-ribose 7.5
DCL 7.4
Tetracaine 7.2
CHAPS 7.1
MAK 7.0
Magnolol 7.0
benzenesulfonic acid 6.9
DBI 6.9
Nicotinic acid adenine dinucleotide phosphate 6.7
Ruthenium red 6.7
dimethyl methylphosphonate 6.7
Ruthenium 6.6
Ruthenium 6.6
CMK 6.6
Thiopental 6.5
Droperidol 6.5
Succinylcholine 6.5
Fluo-3 6.4
Ins(1,4,5)P3 6.2
N-(4-hydroxyphenyl)retinamide 6.2
Triclosan 6.2
APT 6.1
TGR 6.0
Vitamin A 6.0
HCP 6.0
Procaine 5.9
butyl acetate 5.8
Coomassie Blue 5.8
HCP 5.7
AF-2 5.6
ECS 5.6
Isoform 5.5
CCS 5.5
calcium 5.4
Losartan 5.2
Chlorpyrifos 5.2
DIDS 5.1
Inositol 5.1
LCR 5.1
AICAR 5.1
ADP-ribose 5.0
Thapsigargin 5.0
Austin 4.9
Glutaraldehyde 4.9
ATF 4.8
XPA 4.8
POPC 4.8
XPA 4.8
Mg2+ 4.7
Sildenafil 4.7
retinol 4.6
Vasopressin 4.6
DMD 4.6
Statin 4.4
Halothane 4.4
Alanine 4.4
Phenylephrine 4.3
PCP 4.2
AICAR 4.2
Nifedipine 4.2
CPA 4.2
vinyl acetate 4.1
palmitoyl-CoA 4.1
TMB 4.1
CCP 4.1
CPA 4.0
Biotin 4.0
Rapamycin 4.0
Methamphetamine 4.0
Flux 4.0
myricetin 4.0
Lac 4.0
CPA 4.0
ITP 3.8
CPA 3.8
Genistein 3.7
dATP 3.7
HgCl2 3.6
SET 3.6
Calcitonin 3.6
Lidocaine 3.6
Taurine 3.6
UTP 3.5
N-acetyl-D-glucosamine 3.5
ATP 3.5
Ethylene 3.5
isoxazole 3.4
Forskolin 3.4
MTS 3.4
Capsaicin 3.4
benzophenone 3.4
MMC 3.4
Phosphatidylinositol 3.3
naphthoquinone 3.3
BLM 3.3
PPD 3.3
AAA 3.2
Ile 3.2
piperidine 3.2
piperidine 3.2
MCA 3.2
PPD 3.2
MCA 3.2
threonine 3.1
Guo 3.1
cysteine 3.1
CaCl2 3.1
Cysteine 3.0
alanine 3.0
EDS 3.0
Tamoxifen 3.0
N-acetylcysteine 2.9
TCP 2.9
TCP 2.9
Tamoxifen 2.9
TCP 2.9
TCP 2.9
DBP 2.8
pyrene 2.8
asparagine 2.8
retinoic acid 2.8
2-mercaptoethanol 2.8
TOF 2.8
Gly 2.7
DBP 2.6
Resveratrol 2.6
ACh 2.6
2-hydroxyethyl 2.6
2-hydroxyethyl 2.6
2-hydroxyethyl 2.6
2-hydroxyethyl 2.6
2-hydroxyethyl 2.6
2-hydroxyethyl 2.6
2-hydroxyethyl 2.6
AMP 2.6
Arsenic 2.5
Guo 2.5
CCl4 2.5
Asp 2.5
Cholesterol 2.5
arginine 2.4
leucine 2.4
isoleucine 2.4
aspartic acid 2.4
more...