Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P21817 (
RyR1
)
1,154
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We used a combination of bioinformatics, electron cryomicroscopy, and biochemical techniques to identify an oxidoreductase-like domain in the skeletal muscle Ca2+ release channel protein (
RyR1
). The initial prediction was derived from sequence-based fold recognition for the N-terminal region (41-420) of
RyR1
. The putative domain was computationally localized to the clamp domain in the cytoplasmic region of a 22A structure of
RyR1
. This localization was subsequently confirmed by difference imaging with a sequence specific antibody. Consistent with the prediction of an oxidoreductase domain,
RyR1
binds [3H]
NAD+
, supporting a model in which
RyR1
has a oxidoreductase-like domain that could function as a type of redox sensor.
...
PMID:The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain. 1221 69
