Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P21817 (
RyR1
)
1,154
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
DNA double-strand breaks (DSBs) are the most serious DNA damage. Due to a great variety of factors causing DSBs, the efficacy of their repair is crucial for the cell's functioning and prevents DNA fragmentation, chromosomal translocation and deletion. In mammalian cells DSBs can be repaired by non-homologous end joining (NHEJ), homologous recombination (
HRR
) and single strand annealing (SSA).
HRR
can be divided into the first and second phase. The first phase is initiated by sensor proteins belonging to the MRN complex, that activate the
ATM protein
which target
HRR
proteins to obtain the second response phase--repair.
HRR
is precise because it utilizes a non-damaged homologous DNA fragment as a template. The key players of
HRR
in mammalian cells are MRN, RPA, Rad51 and its paralogs, Rad52 and Rad54.
...
PMID:[DNA homologous recombination repair in mammalian cells]. 1707 8
