Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P21817 (RyR1)
 1,154 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objective of this study is to determine whether depression is an independent risk factor for onset of an episode of troublesome neck and low back pain. There is growing evidence that pain problems increase the risk of depression. However, the evidence about the role of depression as a risk factor for onset of pain problems is contradictory. This lack of consistency in research findings may be due in part to methodological weaknesses in existing studies, for example, use of an inappropriate study design and inadequate consideration of confounding. A population-based random sample of adults was surveyed and followed at 6 and 12 months. Individuals at risk of troublesome (intense and/or disabling) neck or low back pain are the subjects of this report (n=790). We used Cox proportional hazards models to measure the time-varying effect of depressive symptoms on the onset of troublesome neck and low back pain. Our multivariable analysis considered the possible confounding effects of demographic and socio-economic factors, health status, co-morbid medical conditions and injuries to the neck or low back. We found an independent and robust relationship between depressive symptoms and onset of an episode of pain. In comparison with the lowest quartile of scores (the least depressed), those in the highest quartile of depression scores had a four-fold increased risk of troublesome neck and low back pain (adjusted HRR 3.97; 95% CI 1.81-8.72). Depression is a strong and independent predictor for the onset of an episode of intense and/or disabling neck and low back pain.
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PMID:Depression as a risk factor for onset of an episode of troublesome neck and low back pain. 1471 99

Malignant hyperthermia (MH) is a rare, potentially lethal disorder of skeletal muscle calcium homeostasis characterized by muscle contracture and life-threatening hypermetabolic crisis following exposure to halogenated anesthetics and depolarizing muscle relaxants. Susceptibility to MH results from mutations in calcium channel proteins that mediate excitation-contraction coupling, with the ryanodine receptor calcium release channel (RyR1) representing the major locus. The mode of inheritance appears to be autosomal dominant with variable penetrance. The authors report the death of a 60-year-old white male with a history of low back pain. He had undergone 2 back surgeries previously, the first occurring 10 years prior to his current presentation. Both previous procedures were done under generalized anesthetic with no complications. Recently, he developed stenosis and presented for fusion of vertebrae L3 and L4. The procedure was performed under general anesthetic including sevoflurane, with no intraoperative complications. The anesthesiologist noted that, near the end of the 2-hour procedure, the decedent's CO2 levels were slightly elevated. After the procedure, the decedent was extubated, the temperature probe which had been recording normal values was removed, and he was rolled from ventral to dorsal position. He immediately became hypotensive and bradycardic. Lifesaving interventions were begun. Subsequently, he went into cardiac arrest, at which time the temperature probe was reinserted into the trachea, where it read a body temperature of 109 degrees F. Malignant hyperthermia protocol was initiated, and interventions continued for over 2 hours, at which time they failed. At autopsy, the abdomen contained 1800 mL of blood, and bilateral hematomas were present in the psoas muscles. The authors present this case of clinically apparent malignant hyperthermia, discuss how to approach such a case, the gross and microscopic findings, ancillary studies, and a review of the literature.
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PMID:Pathologic findings in malignant hyperthermia: a case report and review of literature. 1557 23