Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P21554 (
cannabinoid receptor
)
3,582
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The nuclear receptor
steroidogenic factor 1
(
SF-1
) plays essential roles in the development and function of the ventromedial hypothalamic nucleus (VMH). Considerable evidence links the VMH and
SF-1
with the regulation of energy homeostasis. Here, we demonstrate that
SF-1
colocalizes in VMH neurons with the cannabinoid receptor 1 (
CB1R
) and that a specific
CB1R
agonist modulates electrical activity of
SF-1
neurons in hypothalamic slice preparations. We further show that
SF-1
directly regulates
CB1R
gene expression via a
SF-1
-responsive element at -101 in its 5'-flanking region. Finally, we show that knockout mice with selective inactivation of
SF-1
in the brain have decreased expression of
CB1R
in the region of the VMH and exhibit a blunted response to systemically administered
CB1R
agonists. These studies suggest that
SF-1
directly regulates the expression of
CB1R
, which has been implicated in the regulation of energy homeostasis and anxiety-like behavior.
...
PMID:Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. 1851 94
