Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
substance P 21176
calcitonin 2970
somatostatin 1745
Sep 1398
neuropeptide Y 1395
NK1 1374
polypeptide 1287
bradykinin 1056
vasoactive intestinal peptide 931
neurotensin 894
NK2 775
cholecystokinin 774
tyrosine hydroxylase 702
Met 671
vasoactive intestinal peptide (VIP) 637
short form 637
galanin 609
neurokinin B 608
nitric oxide synthase 547
beta-endorphin 544
Mol 541
bombesin 535
5-hydroxytryptamine 486
dynorphin 484
gut 474
CD57 434
GABA 412
neutral endopeptidase 391
mast cell 387
CGRP 368
neurokinin 1 receptor 355
axonal 347
gastrin 346
vasopressin 342
peroxidase 338
nerve growth factor 337
NK3 receptor 334
NKA 333
choline acetyltransferase 324
VIP 310
ATP 309
angiotensin II 298
cytokine 287
insulin 273
Leu-enkephalin 257
NK-2 244
glucagon 236
acetylcholinesterase 230
opioid receptor 217
Calcitonin 214
oxytocin 212
calbindin 199
Neuropeptide Y 195
peptidase 193
olfactory 181
CCK 180
Met-enkephalin 177
adenylate cyclase 174
IgE 172
NKB 171
gastrin-releasing peptide 160
motilin 159
secretin 157
PGP 9.5 156
NK-2 receptor 156
thyrotropin-releasing hormone 150
cyclooxygenase 150
corticotropin-releasing factor 149
pancreatic polypeptide 147
AMP 147
tumor necrosis factor 146
IL-6 141
neuronal nitric oxide synthase 131
Gen 130
ACTH 128
transient receptor potential vanilloid 1 126
NMDA receptor 125
Ang II 125
NPY 119
TNF 119
collagen 117
TRPV1 116
calretinin 114
parvalbumin 110
amylase 108
lipopolysaccharide 107
prolactin 106
c-fos 98
endothelin-1 98
IL-1 96
LHRH 95
neuron-specific enolase 94
EKC 91
albumin 90
IL-8 88
lymphoid 88
glutamic acid decarboxylase 87
SRIF 86
pituitary adenylate cyclase-activating polypeptide 85
brain-derived neurotrophic factor 84
GTP 83
Vasoactive intestinal peptide 82
muscarinic receptor 80
growth hormone 78
renin 78
dopamine beta-hydroxylase 78
HT3 78
neurotrophin 76
peptide YY 76
TNF-alpha 75
NMR 71
membrane-bound 71
synaptophysin 71
glial fibrillary acidic protein 70
5-HT3 receptor 69
interleukin-6 69
IL-4 68
atrial natriuretic peptide 64
proenkephalin 63
arginine vasopressin 63
NGF 63
vesicular acetylcholine transporter 62
CO2 62
SP1 61
superoxide dismutase 61
DRG 60
calcium channel 60
SP6 59
G protein-coupled receptor 59
glutamate receptor 59
myeloperoxidase 58
calmodulin 58
Leu5 58
lectin 58
PPT 57
TRH 57
rat) 57
Neurokinin B 57
IL-10 57
PKC 56
CSF 56
serum albumin 55
thymus 55
chemokine 53
ERK1 53
acid phosphatase 53
P2X 53
diaphorase 52
bradykinin B2 receptor 51
IL-1 beta 51
collagenase 51
phosphodiesterase 51
LPS 50
glycoprotein 50
aminopeptidase 50
IFN-gamma 49
SCH 49
chromogranin A 49
ATPase 48
NEP 47
more...
Disease
asthma 354
depression 344
cancer 326
varices 284
tumor 235
diabetes 209
Evans 199
multiple endocrine neoplasia 198
hypertension 176
chronic pain 175
pruritus 170
NAME 159
migraine 151
arthritis 144
Parkinson's disease 139
pertussis 129
Alzheimer's disease 128
cold 127
ischemia 102
uterus 100
atopic dermatitis 97
rheumatoid arthritis 94
Huntington's disease 93
SEM 89
cholera 88
psoriasis 80
colitis 74
stroke 73
cornea 71
inflammatory bowel disease 70
irritable bowel syndrome 69
carcinoid 68
astrocytoma 68
osteoarthritis 67
schizophrenia 61
fibromyalgia 60
ureter 60
neuropathy 59
neuroblastoma 59
ulcerative colitis 53
dermatitis 53
celiac disease 52
atherosclerosis 51
SCH 49
Frey 49
carcinoma 48
bronchospasm 48
allergic rhinitis 47
chronic renal failure 45
acute pancreatitis 43
diabetic neuropathy 43
metastases 41
plaque 40
small cell lung cancer 40
SDS 40
major depressive disorder 40
heart failure 39
urethra 39
breast cancer 38
obesity 38
cystitis 38
leukemia 37
peripheral neuropathy 36
aggression 36
Crohn's disease 35
glioma 35
addiction 35
HIV 34
urticaria 33
sepsis 32
periosteum 32
sepsis 31
anxiety disorders 31
carcinoid syndrome 30
chronic obstructive pulmonary disease 30
dementia 30
anaphylaxis 30
PAF 29
sudden infant death syndrome 29
conjunctiva 29
pulmonary edema 28
interstitial cystitis 28
virus infection 28
rhinitis 28
aqueous humor 27
subarachnoid hemorrhage 27
nerve lesion 27
sensory neuropathy 27
intraocular pressure 26
disinhibition 26
emotional stress 26
psychological stress 26
pancreatitis 25
gastroesophageal reflux disease 25
skin disease 25
monoarthritis 24
myocardial ischemia 24
lung cancer 24
Lissauer 24
epilepsy 24
chronic bronchitis 24
Contact Dermatitis 24
hyperglycemia 24
essential hypertension 23
regional pain syndrome 23
alcoholism 23
parkinsonism 22
schistosomiasis 22
Blocking 22
synovitis 21
adenocarcinoma 21
pulmonary hypertension 21
vagina 21
Pituitary 21
multiple sclerosis 20
uterine cervix 20
uvea 20
LAD2 20
eosinophilia 20
incontinence 19
type 2 diabetes 19
myocardial infarction 19
eczema 19
autonomic neuropathy 19
tumor growth 18
dyskinesia 18
herpes simplex 18
melanoma 18
PHA 17
Bladder 17
dysphagia 17
osteoporosis 17
lymphatic vessels 17
Bladder 17
ash 17
pheochromocytoma 17
Bladder 17
meninges 16
amyotrophic lateral sclerosis 16
dehydration 16
pneumonia 16
ATM 16
ICS 16
neuroma 16
cardiovascular disease 16
cognitive impairment 16
middle ear 15
Brown 15
inflammatory joint disease 15
PNS 15
hypercholesterolemia 15
RSV infection 15
infectious diseases 15
MIP 15
GSH 14
aspiration pneumonia 14
GAD 14
AIDS 14
drug addiction 14
cystic fibrosis 14
more...
Symptom
pain 1787
analgesia 236
vomiting 167
cough 144
anesthesia 127
headache 121
diarrhea 86
nausea and vomiting 84
Welt 69
seizures 66
constipation 60
nausea 41
acute pain 36
erythema 33
abdominal pain 30
hypercapnia 30
sneezing 29
flushing 29
low back pain 27
spasm 23
back pain 23
functional recovery 20
discomfort 20
retching 20
discomfort 20
Neuropathic pain 20
acute stress 18
fatigue 18
hypothermia 17
myalgia 17
dystonia 17
dyspnea 16
Deafferentation 16
anorexia 16
angina 16
arthralgia 16
rhinorrhea 16
pelvic pain 14
spasticity 12
hyperoxia 11
chronic cough 11
hunger 11
starvation 11
ataxia 10
respiratory distress 10
cancer pain 10
neuralgia 10
chorea 10
dental pain 10
acidity 10
exhaustion 9
agitation 9
nasal congestion 9
chronic constipation 9
bladder pain 8
urinary frequency 8
orofacial pain 8
twitching 8
dry eye 8
tachypnea 8
insomnia 7
facial pain 7
weakness 7
bradykinesia 6
skin irritation 6
bone pain 6
neck pain 5
numbness 5
knee pain 5
Ill 5
shoulder pain 5
distraction 5
wheezing 5
Visceral pain 5
collapse 5
sleepiness 4
hyperesthesia 4
polydipsia 4
apathy 4
labored breathing 4
dysesthesia 4
pallor 4
paresthesia 4
sciatica 4
colic 4
tremor 4
vertigo 4
hypocapnia 3
incoordination 3
thinning 3
HSA 3
chest pain 3
Postoperative pain 3
paresis 3
polyuria 3
Flare 3
sighing 3
Gastrointestinal symptoms 3
syncope 3
dry skin 3
clonus 2
microbial colonization 2
Excitability 2
cachexia 2
hypalgesia 2
photophobia 2
localized edema 2
bitter taste 2
Postoperative nausea and vomiting 2
Decreased activity 2
chronic back pain 2
enuresis 2
hypertonia 2
myoclonus 2
Wind 2
joint stiffness 2
cyanosis 2
Persistent dry cough 2
Chronic pelvic pain 2
Lower urinary tract symptoms 2
generalized pain 2
dizziness 2
atypical chest pain 2
hemiplegia 2
despair 2
regurgitation 2
POA 2
nerve pain 2
abdominal cramps 2
Inflammatory pain 2
nasal discharge 2
masculinization 1
non-productive cough 1
Catch 1
Skin hyperemia 1
leg cramps 1
dysuria 1
shortness of breath 1
lethargy 1
hyperemesis 1
ataxic gait 1
tingling 1
Esophageal pain 1
emaciation 1
tonic seizure 1
general problem 1
Ear swelling 1
meningism 1
vestibulitis 1
prickling sensation 1
UTI symptoms 1
skin damage 1
peritoneal pain 1
thirsty 1
Spontaneous nystagmus 1
belching 1
abdominal discomfort 1
skin irritant 1
Sympathetically maintained pain 1
oliguria 1
more...
Drug
Dermatol 222
Atropine 131
Histamine 116
Cardiovasc 85
CSF 76
Indomethacin 68
lysine 65
nitroglycerin 64
Nephron 63
Asn 53
citric acid 49
IFN-gamma 49
Aprepitant 47
Phosphoramidon 44
IL-2 38
caffeine 38
Biopolymers 33
ICI 33
Gel 30
Captopril 28
Angiotensin II 28
MAP 23
Clonidine 22
Asthma 19
Sodium nitroprusside 18
p75 17
DHT 17
Glucagon 17
DHT 17
Monit 16
ascorbate 16
ETA 16
Forskolin 15
HCH 15
CTX 15
TAK 15
GRF 13
CaCl2 13
CaCl2 13
CaCl2 13
Secretin 12
Leaf 11
Phentolamine 11
Ethanol 11
Guanethidine 11
Citric acid 10
ISP 10
CTX 10
CTX 10
PCP 10
Theophylline 10
Raloxifene 9
Apomorphine 9
Nedocromil sodium 8
Nitric Oxide 8
Ringer's solution 8
Kainic acid 8
Allergen 8
ABC 8
PTH 7
Scopolamine 7
BoNT/A 7
Ketotifen 7
Adenosine triphosphate 7
ROS 7
Pregabalin 7
NH3 7
GHRP 6
Paraffin 6
Reserpine 6
Salbutamol 6
Fluorescein 6
Tubocurarine 6
Methylene blue 6
vitamin E 6
DFP 6
Diphenhydramine 6
NADH 6
Oxaliplatin 5
CAM 5
Fluorescein 5
CoCl2 5
Ginger 5
CoCl2 5
Ouabain 5
Propofol 5
Pilocarpine 5
Bisacodyl 5
Fragment 4
Amiloride 4
Enalaprilat 4
TAC 4
pyridoxal phosphate 4
NAG 4
Aprotinin 4
MgSO4 4
Amiloride 4
Tacrolimus 4
Ipratropium bromide 4
Capsicum 4
G-CSF 4
CEC 4
Vinpocetine 4
Enalaprilat 4
Epinastine 3
Lioresal 3
Papaverine 3
Iloprost 3
IL-1ra 3
SMP 3
Cimetidine 3
9-THC 3
Bumetanide 3
Budesonide 3
Sulpiride 3
Portal 3
Luteinizing 3
Codeine 3
balanced salt solution 3
Cimetidine 3
EE2 3
Estrogens 3
Adenosine deaminase 3
Gabapentin 3
CPM 3
Nephron 3
Netupitant 3
Cilostazol 2
Acacia 2
Aminoguanidine 2
Agomelatine 2
Fentanyl 2
DMI 2
Drotrecogin alfa 2
Rolipram 2
CTT 2
ROC 2
Leucin 2
Prednisolone 2
Spectrum 2
Tranilast 2
ALA 2
Helium 2
Hypaque 2
Growth hormone 2
ADM 2
Fraction 2
Domperidone 2
Imiquimod 2
HCG 2
Zaltoprofen 2
K-252a 2
Rizatriptan 2
ETS 2
IL-11 2
lactose 2
Gastro 2
Fenoterol 2
Sandostatin 2
Isotretinoin 2
more...
Enzyme
tyrosine hydroxylase 677
CD10 480
peroxidase 428
choline acetyltransferase 326
protein kinase C 262
acetylcholinesterase 244
adenylate cyclase 178
NO synthase 178
phospholipase C 155
ACE 149
mitogen-activated protein kinase 146
protein kinase 137
ERK 127
NADPH-diaphorase 120
trypsin 119
renin 78
dopamine beta-hydroxylase 67
tryptase 67
superoxide dismutase 67
collagenase 58
ATPase 56
acid phosphatase 55
guanylate cyclase 55
NOS 53
diaphorase 52
NQO1 52
diaphorase 52
phospholipase A2 52
phosphodiesterase 51
prolyl endopeptidase 44
chymotrypsin 43
thrombin 42
catalase 41
lipoxygenase 41
glutamate decarboxylase 41
dipeptidyl peptidase IV 39
reverse transcriptase 38
cholinesterase 37
enolase 36
alkaline phosphatase 35
chymase 31
caspase-3 30
tryptophan hydroxylase 28
CD13 28
monoamine oxidase 27
MEK 26
kallikrein 26
luciferase 24
RNA polymerase 20
lactate dehydrogenase 19
urease 18
urease 18
focal adhesion kinase 18
lysozyme 17
calcineurin 17
RNase 17
cytochrome oxidase 17
ACS 17
botulinum neurotoxin 17
transglutaminase 15
MIP 15
carbonic anhydrase 15
neuraminidase 15
RNase 15
aspartate aminotransferase 14
transcriptase 14
hyaluronidase 14
hyaluronidase 13
beta-galactosidase 13
hexosaminidase 13
endothelin-converting enzyme 13
MMP-3 13
NADPH oxidase 13
tissue plasminogen activator 13
adenosine deaminase 12
cathepsin D 12
NADPH oxidase 12
aminopeptidase P 12
MAP 12
pepsin 12
adenosine deaminase 12
phenylethanolamine N-methyltransferase 11
PCP 11
AST 10
glutathione peroxidase 10
CPN 10
myosin light chain kinase 10
histidine decarboxylase 10
papain 10
thermolysin 10
invertase 9
neurolysin 9
CaMKII 9
phosphatidylinositol 3-kinase 9
carboxypeptidase Y 9
carboxypeptidase E 8
aromatic L-amino acid decarboxylase 8
AMPK 8
PKG 8
BAL 8
aldose reductase 8
PAM 8
nitrate reductase 7
nitrate reductase 7
nitrate reductase 7
DNase 7
thimet oligopeptidase 7
nitrate reductase 7
lipoprotein lipase 7
cathepsin G 7
beta-glucuronidase 7
nitrate reductase 7
nitrate reductase 7
ribonuclease 7
ricin 7
ribonuclease 7
leucine aminopeptidase 6
SPC 6
succinate dehydrogenase 6
thromboxane synthase 6
glutaminase 6
GABA transaminase 6
carboxypeptidase B 6
xanthine oxidase 6
DOPA decarboxylase 6
tyrosinase 6
glutamine synthetase 6
lipase 6
alpha-amylase 6
GSK 6
deaminase 6
protein phosphatase 2A 6
phosphoinositide 3-kinase 6
furin 5
glutathione reductase 5
PDE 5
CYP3A4 5
phospholipase D 5
prostaglandin synthetase 5
SMP 5
alanine aminotransferase 5
PRA 5
tissue kallikrein 5
elastase 5
sucrase 5
caspase-1 5
PARP 5
5'-nucleotidase 5
aequorin 5
proteasome 5
cellobiohydrolase 5
PI-PLC 4
ornithine decarboxylase 4
matrix metalloproteinase 9 4
sphingosine kinase 4
SST 4
PAL 4
apyrase 4
P-glycoprotein 4
neutrophil elastase 4
more...
Compound
Substance P 3231
Dec 1538
calcium 1337
methionine 972
arginine 719
nitric oxide 666
glutamate 640
5-HT 622
sodium 621
leucine 606
noradrenaline 555
water 541
Phe 489
potassium 489
Capsaicin 470
Clin 468
GABA 425
GABA 417
nitrogen 319
ATP 317
Gly 308
tyrosine 304
NH2 281
lysine 271
phosphate 268
His 248
gamma-aminobutyric acid 246
Calcitonin 213
cAMP 207
ACh 205
alanine 200
DNA 184
oxygen 184
phosphorus 177
NMDA 169
Ile 168
acetate 162
AMP 156
glucose 131
Atropine 131
ACTH 129
cGMP 128
Bradykinin 127
Asp 126
ethanol 125
acetic acid 123
salt 119
TNF 119
Histamine 116
isoleucine 114
isoleucine 114
sulfate 113
silver 111
hydrogen 101
Neurotensin 91
proline 90
Morphine 90
zinc 90
PGE2 89
serine 87
CO2 86
GTP 83
Neuronal 80
threonine 80
prostacyclin 79
TRH 77
tryptophan 74
Tetrodotoxin 73
Naloxone 73
Indomethacin 66
AMPA 66
HCl 65
nitrate 65
benzamide 64
Mg2+ 62
ammonium 62
Norepinephrine 60
Dopamine 59
formaldehyde 59
PGE 58
fluorine 57
tryptophan 57
tryptophan 57
tryptophan 57
ADP 55
copper 52
EDTA 52
Angiotensin II 52
nicotinamide 51
EDTA 50
cadmium 46
SDS 46
Glutamate 46
prostaglandin E1 45
Carbachol 44
Phosphoramidon 44
ADP 44
bromide 44
hydroxyindoleacetic acid 44
ADP 44
L-DOPA 43
Adenosine 42
aldosterone 42
glutamic acid 42
cysteine 41
glutamine 39
urea 38
caffeine 38
ammonia 38
cobalt 37
methanol 36
Dynorphin 35
Hoe 35
galactose 35
manganese 35
ICI 34
aspartic acid 34
DAMGO 33
Adrenal 33
COS 32
nickel 32
MPTP 32
octane 31
piperidine 31
piperidine 31
TOF 31
formaldehyde 31
D-Ala 30
Cardiol 29
GDP 29
NADPH 28
GMP 28
Nicotine 28
NADPH 28
PAP 27
APV 27
PAP 27
LTC4 27
PAP 27
PAP 27
Triton X-100 26
toluene 26
Nifedipine 26
Cereb 25
PGD2 25
DMSO 25
T10 25
iodine 25
barium 24
Hexamethonium 24
Ruthenium red 23
SP 1 23
propionic acid 23
H2S 23
Evans Blue 23
5-hydroxytryptophan 23
propionic acid 23
aldehyde 23
Isoproterenol 22
Dexamethasone 22
more...