Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20366 (
substance P
)
21,176
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Reg IV
is a 17 kD secreted C-type lectin physiologically found in selected enteroendocrine cells (EEC). It is thought be involved in the regulation of normal and pathological intestinal and/or neuroendocrine differentiation and proliferation but its ultimate functional role(s) is still unclear. We used immunostaining and compared the cellular expression of
Reg IV
with a panel of neuroendocrine markers in human GI-tract tissue samples.
Reg IV
showed cellular co-distribution with serotonin and chromogranin A in all parts of GI-tract. Co-localization of
Reg IV
with somatostatin was seen in colon and with
substance P
in ileum. Subpopulations of cells expressing
Reg IV
overlapped with EECs containing GLP-1, GLP-2, secretin, PYY, and ghrelin, depending on the anatomical localization of the samples. The results further underscore the high degree of diversity among EECs and suggest that
Reg IV
may be involved in the finetuning of functions exerted by the neuroendocrine cells in the GI-tract.
...
PMID:Reg IV is differently expressed in enteroendocrine cells of human small intestine and colon. 2349 1
