Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the present study was to check if Substance P (SP) is released from the hypothalamus into the hypophysial portal vessels and by this route exerts its direct influence on the adenohypophysis. For this purpose SP radioimmunoactivity was assayed in the blood plasma collected from hypophysial portal vessels and from the cephalic end of the external jugular vein. The SP levels in blood plasma collected from hypophysial portal vessels and from the jugular vein do not differ significantly. Neither does application of a noxious factor, such as bilateral femoral bone fracture, change significantly the SP level in the blood plasma from portal vessels and from the jugular vein. Hypoxia seems to increase the SP level in portal blood plasma and may be followed by its decrease. It is concluded that hypothalamic SP is not released into the hypophysial portal vessels under normal conditions and its direct influence on the adenohypophysis is not mediated this way.
Acta Physiol Pol
PMID:Substance P in the blood plasma in hypophysial portal vessels. 243 97

The effects of intra-arterial administration of substance P upon intestinal blood flow, oxygen consumption, intestinal motor activity, and distribution of blood flow to the compartments of the gut wall were measured in anesthetized dogs. Blood flow to the segment of distal ileum was measured with an electromagnetic blood flow meter and A-VO2 was measured spectrophotometrically. Oxygen uptake was calculated as the product of A-VO2 and total blood flow. The clearance of 86Rb was measured to estimate the density of the perfused intestinal capillaries. Changes in blood flow distribution were estimated from the distribution of radiolabeled microspheres. Motor activity was monitored from changes in intraluminal pressure. Substance P induced a dose-related increase in intestinal blood flow, oxygen consumption, and intestinal motor activity. A significant increase in 86Rb clearance and increase in blood flow to the muscles was also observed. The results of these studies indicate that substance P relaxes intestinal arterioles and precapillary sphincters thereby inducing intestinal hyperemia and increased oxygen consumption. These changes, at least in part, might be due to the increased intestinal motility with enhanced metabolic demands of the muscularis for oxygen.
Acta Physiol Pol
PMID:Effects of substance P on intestinal circulation and oxygen consumption. 245 35

Dekanski's method was used to estimate the pressor activity of the extracts of the posterior pituitary lobe in anaesthetized rats, after the infusion of 0.9% NaCl solution above the supraoptic nuclei and haemorrhage in the amount of 1.5% of body weight or after the infusion of Substance P solution above the supraoptic nuclei and haemorrhage. It has been found that the vasopressin content in the posterior pituitary lobe decreased about 20% after the infusion of 0.9% NaCl solution and haemorrhage. The infusion of Substance P above the supraoptic nuclei inhibits the loss of vasopressin from the pituitary caused by haemorrhage.
Acta Physiol Pol
PMID:The effect of substance P (SP) infusion above the supraoptic nuclei of hypothalamus on the vasopressin content in the posterior pituitary lobe after haemorrhage in rats. 246 61

The lesions of medial habenular nuclei increased the pain sensitivity, enhanced the analgesic activity of morphine and slightly activated the behavior. The lesion of fasciculus retroflexus, a pathway connecting habenular nuclei with interpeduncular nucleus enhanced the pain sensitivity less markedly, did not change the efficacy of morphine analgesia, but significantly increased the activity of animals. The lesion of interpeduncular nucleus influenced the pain sensitivity to a smallest degree, did not change the analgesic activity of morphine, but dramatically increased the activity of animals. The activation did not resemble the aimless excitation of amphetamine-treated or raphe-lesioned rats, and no signs of increased emotionality or irritability were noted. The results are interpreted as an evidence of habenulo-interpenduncular complex being a part of a system, involved in the regulation of behavioral activity and the sensitivity to the aversive stimuli. These functions are in all probability mediated partly through substance P and met-enkephalin containing neurons, present in these structures.
Pol J Pharmacol Pharm
PMID:Habenulo-interpeduncular lesions: the effects on pain sensitivity, morphine analgesia and open-field behavior in rats. 390 26

The effect of intracerebroventricular administration of Substance P fragment and met-enkephalin on the excitability of two generators of hippocampal theta rhythm was investigated in the experiments performed on chronic rabbits. Substance P had a strong facilitatory effect on the threshold of the generator of the hippocampal theta rhythm of the frequency 4-7 c/s and an inhibitory effect on the threshold of the generator of the 7-12 c/s frequency evoked by stimulation of the midbrain reticular formation. These effects were dose dependent. The effects of met-enkephalin were opposite. They increased the threshold of the 4-7 c/s hippocampal generator and decreased the threshold of the other generator. The effect of these two compounds was evaluated according to the energy of electrical trains of pulses maintaining the continuous arousal pattern in the hippocampus.
Acta Physiol Pol
PMID:The effect of intracerebroventricular administration of substance P fragment and met-enkephalin on the transmission of nervous impulses between the midbrain reticular formation and two generators of the hippocampal theta rhythm in rabbits. 608 16

The purpose of the reported experiments was the study of the effects of intracerebroventricular (i.c.v.) administration of substance P (SP 1--11) and its hexapeptide C-terminal fragments SP 6--11 and (pGlu6)SP6--11 on the length of the estrus cycle. In the animals with a regular sequence of estrus aliquots of 250 pmol of the three peptides: SP 1--11, SP 6--11 and (pGlu6)SP 6--11 on the carier dextrane were infused into the left lateral cerebral ventricle through a chronically implanted cannula. For control, dextran solution in 0.9% NaCl was infused in a similar way. I.c.v. infusion of dextran in 0.9% NaCl, SP 1--11 and (pGlu6)SP 6--11 caused no significant changes in the length of the estrus cycle during which the infusion was done. Infusion of SP 6--11 prolonged the diestrus phase in most animals. This observation indicates that SP 6--11 exerted an effect on the hypothalamic mechanism controlling the secretion of gonadotropins by the hypophysis.
Acta Physiol Pol
PMID:Effect of intracerebroventricular administration of substance P and its hexapeptide fragment on the estrus cycle in female rats. 616 49

The content of substance P(SP) in the rat forebrain was assayed by radioimmunoassay technique after apomorphine and haloperidol injection. Apomorphine (1 and 10 mg/kg) produced dose-dependent decrease in SP content, while haloperidol, 0.2 and 1 mg/kg produced a marked increase in SP level in the forebrain. The results may suggest a modulatory role for SP in the action of dopamine receptor agonists and antagonists.
Pol J Pharmacol Pharm 1981
PMID:Substance P levels in the rat forebrain after apomorphine and haloperidol treatment. 617 59

Effects of substance P (SP) administered into anterior hypothalamus or lateral ventricle on body temperature were investigated. When administered into lateral ventricle in doses from 20 to 2000 ng SP failed to influence body temperature. Application of SP into anterior hypothalamus in the same doses (20-2000 ng) resulted in a mild but insignificant increase in body temperature. No visible changes in the behavior of the rats, except slight sedation after the highest dose administered into lateral ventricle, were observed after application of SP. These results suggest that SP does not play any essential role in thermoregulation.
Acta Physiol Pol
PMID:Effect of intracerebral administration of substance P on body temperature. 618 46

Seven pentapeptides, chemically related both to C-terminal fragment of substance P and Met-enkephalin were synthetized and their pharmacological properties were investigated. Peptides I-VI (L-amino acid residue in position 2) antagonized the inhibitory action of D-Ala2-Met-EK-NH2 on isolated vas deferens in vitro but were devoid of opiate-receptor binding activity in radioreceptor studies. Peptide VII (D-Phe2-Met-EK-NH2) exerted a weak inhibitory effect on contractions of transmurally stimulated vas deferens of rat which was abolished by naloxone (10(-8) M) and showed relatively strong but short-lasting analgesic activity in vivo. This peptide at concentration above 10(-5) M partially displaced the 3H-naloxone from its binding sites in striatal membranes. The possible existence of the neuronal substance P-enkephalin self-regulatory mechanism is discussed.
Pol J Pharmacol Pharm 1982
PMID:An approach to the elucidation of self-regulatory mechanism of substance P action. I. Synthesis and biological properties of pentapeptides related both to the substance P C-terminal fragment and enkephalins. 618 34

Male Wistar rats were treated with pethidine (PT) or fentanyl (FN) subcutaneously (sc) followed by intrathecal (ith) non analgesic doses of methionine- (MENK) or leucine-enkephalin (LENK), neurotensin, (NT), substance P (SP) or cholecystokinin octapeptide 26-33 (CCK-8). Then the antinociceptive effect was measured during 1 h using tail-immersion test. LENK potentiated strongly PT and FN analgesia. MENK antagonized PT analgesia only transiently 30 min after administration and transiently potentiated FN analgesia. SP and CCK-8 potentiated significantly PT analgesia, whereas NT acted biphasically: increasing and then decreasing PT analgesia. SP, CCK-8 and NT augmented FN analgesia. Naloxone inhibited analgesia elicited by the studied opioids and neuropeptides. These data show that LENK affects similarly the analgesic effects of both studied opioids, whereas MENK acted differently on PT and FN analgesia. This may suggest that individual enkephalins have different pharmacological features when interacting with different analgesics. Also NT interacted differently with pethidine and fentanyl.
Pol J Pharmacol
PMID:Pharmacological interaction between neuropeptides and pethidine or fentanyl in rat spinal cord. 751 84


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