Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Effects of ageing on nicotine-induced contraction and release of substance P-like materials in the bronchial preparations from guinea-pigs of different ages were studied. 2. The pD2 value (potency) of nicotine decreased with age from 10 to 100 weeks. The pD2 value of substance P did not change with age suggesting that substance P receptor mechanisms do not alter with age. 3. The amount of substance P-like materials released by nicotine (10(-4) M) decreased with age from 10 to 100 weeks, supporting our previous findings that nicotine contracts the guinea-pig bronchus through the release of substance P-like materials. 4. These results suggest that the age-related decrease in the pD2 value (potency) of nicotine is due to the reduction in the amount of substance P-like materials released by nicotine.
Gen Pharmacol 1991
PMID:Effects of ageing on nicotine-induced contraction and substance P-like materials release in guinea-pig bronchus. 172 81

1. We have used synaptosomal membranes to study the influence of substance P and its fragments and analogues of its C-terminal fragment on Ca2+/calmodulin-dependent synapsin I endogenous phosphorylation. 2. SP1-11, SP1-4, [Tyr8]SP6-11 and [pGlu6, Tyr8]SP6-11 at 10(-3) M greatly inhibited synapsin I phosphorylation. 3. SP6-11 at all investigated concentrations and SP1-11, SP1-4, [Tyr8]SP6-11, [pGlu6, Tyr8]SP6-11 at 10(-4) and 10(-5) M were ineffective. 4. The results indicate that SP1-11 and its N-terminal fragment and analogues of its C-terminal fragment act on the phosphorylation of specific synaptic protein (synapsin I) and therefore may influence the release of neurotransmitters, membrane conductance and potentiation or inhibition of other signalling systems.
Gen Pharmacol 1991
PMID:Substance P and its fragments affect Ca2+/calmodulin-dependent synaptosomal membrane protein phosphorylation from rat cerebral cortex. 172 84

1. Effects of inhibition of angiotensin converting enzyme (ACE, EC 3.4.15.1) in brain on psychomotor, exploratory, stereotyped and cognitive behaviour in rats were investigated. To inhibit brain ACE captopril (D-3-mercaptopropanoyl-L-proline) was given orally (p.o., 50 mg/kg) or intracerebroventricularly (i.c.v., 5 micrograms/rat). 3. Captopril given p.o. but not i.c.v. significantly enhanced stereotypy, overall number of conditioned avoidance responses, and decreased blood pressure. 4. No statistically significant influence of captopril given by either route on the number of crossings, rearings and bar approaches in the open field, performance of passive avoidance and number of correct choices as well as the speed of running for food in the T-maze was observed. 5. In conclusion, a small decrease of the activity of nigrostriatal dopaminergic system caused by the decrease of AII and/or increase of bradykinin, substance P, enkephalins and neurotensin in brain resulting from ACE inhibition is postulated.
Gen Pharmacol 1990
PMID:Some behavioural effects of captopril in rats. 227 85

1. Nicotine-induced contraction of bronchial preparations isolated from 3, 6, 10, 50 and 100 week old guinea-pigs were studied. 2. Contractile responses to nicotine were inhibited by hexamethonium and a substance P antagonist but not by atropine or tetrodotoxin, suggesting that the nicotine-contraction was mediated through a release of substance P-like material(s). 3. The pD2 value (potency) of nicotine did not change with age from 3 to 10 weeks but decreased thereafter to 100 weeks, while no age-related change was found in the pD2 value of substance P. The pA2 value of hexamethonium did not change with age, suggesting that the affinity of drugs to nicotine receptors does not change with age. 4. These results suggest that possibility that age-related change in the pD2 value of nicotine is due to a change in the amount of nicotine receptors but not to a change in the affinity of nicotine to its receptors.
Gen Pharmacol 1990
PMID:Effect of ageing on nicotine-induced contraction of guinea-pig bronchial preparation. 234 Oct 16

The influence in vitro of analogues of Sp5-11 and SP6-11 substance P fragments on the activity of monoamine oxidase (MAO) in homogenates and crude mitochondrial fractions of rat brain was examined. The rat brain was divided into: I--cerebral cortex, II--hippocampus, III--midbrain, IV--thalamus with hypothalamus, V--cerebellum and VI--medulla oblongata. The obtained results proved that the analogues of SP fragments inhibit selectively the activity of the enzyme in the homogenates of cerebral cortex, hippocampus, midbrain and cerebellum. In the crude mitochondrial fractions the applied analogues of SP fragments caused a slight increase of the enzyme activity. The most significant changes in the activity of MAO were observed in hippocampus homogenate fraction.
Gen Pharmacol 1985
PMID:Effects of analogues of substance P fragments on the MAO activity in rat brain. 241 Mar 26

Endocrine cells in the gut of Sparus auratus L. (gilt-head sea bream) have been demonstrated by immunocytochemical and electron microscopic techniques. Cells showing somatostatin and gastrin-like immunoreactivity were found in the depth of the gastric folds and in the upper part of the stomach glands while substance P immunoreactive cells were present between the upper epithelial cells of the gastric folds. Cells showing gastrin, substance P, pancreatic polypeptide, cholecystokinin, and Met-enkephalin immunoreactivity were observed in the intestinal mucosa scattered between epithelial cells. Eight types of endocrine cells were ultrastructurally characterized by the shape, size, and electron density of their respective secretory granules. A tentative correlation between these diverse cell types and those identified by immunocytochemical techniques has been established.
Gen Comp Endocrinol 1986 Dec
PMID:An immunocytochemical and ultrastructural study of endocrine cells in the gut of a teleost fish, Sparus auratus L. 243 80

Several antisera specific to neuropeptides of vertebrates were applied to sections of the earthworm Eisenia fetida Sav. Some of them were able to reveal specific neurones of the supraoesophageal ganglion: h-GHRF, CRF, Leu- and Met-enkephalin, dynorphin, substance P, CCK-8, and CCK-8S. A map of different areas or nuclei was established in the brain, taking position of reactive cells into account. Four symmetrically paired nuclei and one mediodorsal nucleus were identified and plotted. There is generally no characteristic modification correlated with maturation of the worms. However, the reaction against anti-Leu-enkephalin differs significantly according to age of Eisenia in nucleus No. 1 and particularly in nuclei No. 2 where one cell group presents specific reactivity on and after puberty. Moreover, the successive application of two antisera to the same sections after elution showed no coexistence of substances in a single neurone. By comparison with these vertebrate peptide-like containing nerve cells, the assay to anti-5-HT showed only a few reactive aminergic neurones. An attempt of correlation of cellular types with reactive perikarya is started.
Gen Comp Endocrinol 1987 Mar
PMID:[Establishment of a map of neurons in the brain of Eisenia fetida (Annelida, Oligochaeta) containing substances immunologically specific to vertebrate peptides]. 243 10

The in vitro effects of synthetic substance P (SP) on rings of the ventral aorta and on the systemic heart of Myxine glutinosa were investigated by the use of an organ bath. Increasing molar amounts (10(-16) to 10(-8) M) of SP were applied and the reaction of the aortic rings was recorded with isometric transducers. SP was found to contract the Myxine aorta in a dose-dependent manner starting at a threshold concentration of 10(-14) M and reaching a plateau at 10(-11) M. Therefore, the effective dose of SP seems to be in a physiological range. On the other hand, the heart was found to be insensitive to SP even in doses as high as 10(-5) M. By means of immunohistochemistry, SP-immunoreactive endocrine cells were found throughout the Myxine intestine while no SP-immunoreactive nerve fibers were detected at the Myxine aorta. Thus, under physiological conditions the observed contractile effect of SP on the ventral aorta may be raised by SP-like material released from enteroendocrine cells.
Gen Comp Endocrinol 1987 May
PMID:Substance P is a vasoactive hormone in the Atlantic hagfish Myxine glutinosa (Cyclostomata). 243 87

Immunochemical studies were carried out on the ascidian Ciona intestinalis to determine the character and distribution of the tachykinins neurokinin A (NKA) and substance P (SP). Antisera specific for the C-terminus of mammalian SP, and for the N-terminus of mammalian SP and NKA, were used to monitor tissue extracts from Ciona. Parallel immunocytochemical studies assessed the distribution of these tachykinins in the central and peripheral nervous systems as well as their occurrence in endocrine cells. HPLC and radioimmunoassay established the presence of both C-terminal SP and NKA-like material in extracts from neural ganglion and body wall/pharynx. Immunocytochemistry revealed the C-SP material to be present in a population of small neuronal cell bodies and fibers in the ganglion as well as in cell bodies and fibers in the periphery. The NKA-like material was restricted to separate and larger neuronal perikarya in the ganglion while in the periphery its distribution reflected that of the C-SP-like material. Endocrine cells in the pharyngeal epithelium were reactive only with the C-terminal SP antiserum. N-terminal SP antisera were unreactive both in radioimmunoassay and immunocytochemistry. These findings are in accord with the idea that the tachykinin family is represented by at least two of its members at the prevertebrate stage of evolution. Interestingly, the SP-like material shows strong C-terminal homology with the mammalian peptide but little N-terminal similarity. Furthermore, the NKA-like peptide is restricted to the nervous system while SP-like molecules may be found in both central and peripheral neurons as well as endocrine cells in the pharynx.
Gen Comp Endocrinol 1987 Jun
PMID:Tachykinins in the central and peripheral nervous system of the ascidian Ciona intestinalis. 244 Jul 62

Adrenergic and osmoregulatory responses to substance P (SP) were studied in salt-loaded ducks. SP inhibited nasal salt secretion by decreasing the salt concentration of the nasal fluid, but reversed the inhibitory effect of angiotensin II (ANG II) on nasal water and K secretion. SP also stimulated salivation, urinary water excretion, and urinary salt excretion, but diminished the diuretic and saluretic responses to ANG II. The osmoregulatory effects of SP were accompanied by elevated plasma concentrations of norepinephrine and epinephrine. The data suggest that SP may contribute to adrenergic and osmotic regulation in ducks.
Gen Comp Endocrinol 1987 Aug
PMID:Reevaluation of the effect of substance P on nasal salt gland secretion in the duck (Anas platyrhynchos). 244 66


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