Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Both LC and capillary LC (CapLC) have been successfully interfaced with inductively coupled plasma mass spectrometry (ICP-MS). Gradients of acetonitrile and aqueous based solvents have been employed to separate several compounds of pharmaceutical interest. This paper will describe four application areas in the pharmaceutical industry, and examples will be shown where CapLC, LC and gel electrophoresis via laser ablation have been coupled with ICP-MS. The four areas highlighted in this paper are: (1) the use of derivatisation reactions to "make the invisible visible". Methods involving derivatisations with copper and iron will be described that can be used for the analysis of amines and carboxylic acids by ICP-MS. (2) The profiling of metal ion content (in particular bromine) in biological samples such as human plasma, this study will focus on the metabolism of bromine-labelled peptides (e.g. substance P). (3) The analysis of materials derived from single, solid-phase beads used in combinatorial chemistry, and (4) also discussed will be our findings from investigations into the use of laser ablation ICP-MS on the determination of protein phosphorylation on electrophoresis gel blots.
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PMID:Liquid chromatography coupled with inductively coupled plasma mass spectrometry in the pharmaceutical industry: selected examples. 1559 26

Concentrations of trace elements in wheat grain sampled between 1967 and 2003 from the Swedish long-term soil fertility experiments were analyzed using ICP-MS. The long-term effect of inorganic and organic fertilization on trace metal concentrations was investigated including the impact of atmospheric deposition and myccorhiza, whereas other factors such as soil conditions, crop cultivar, etc. are not discussed in this paper. Mean values derived from 10 experimental sites were reported. Significantly declining Pb and Cd concentrations in wheat grain could be explained by lower atmospheric deposition. Mean Se contents in all samples were 0.031 mg kg(-1) grain dry weight. No samples had sufficiently high Se concentrations for human (0.05 mg Se kg(-1)) or animal demand (0.1 mg Se kg(-1)). Concentrations of Co in wheat grain were extremely low, 0.002-0.005 mg Co kg(-1) grain dry weight, and far below the minimum levels required by animals, which applied to all fertilizer treatments. A doubling of Mo concentrations in grain since 1975 resulted in Cu/Mo ratios often below one, which may cause molybdenosis in ruminants. The increase in Mo concentrations in crops correlated with the decline in sulfur deposition. Concentrations of Cu and Fe declined in NPK-fertilized wheat as compared to unfertilized or manure-treated wheat. Very low concentrations of Se and Co and low concentrations of Fe and Cu require attention to counteract risks for deficiencies. The main characteristic of the study is that there are few significant changes over time between different fertilizer treatments, but throughout there are low concentrations of most trace elements in all treatments. In general, good agreement between concentrations in wheat from the long-term fertility experiments and the national monitoring program indicate that values are representative.
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PMID:Trace element concentration in wheat grain: results from the Swedish long-term soil fertility experiments and national monitoring program. 1926 25

A long-term field experiment and ICP-AES analysis were conducted to study concentration and content of micronutrients Mn and Zn in maize under different fertilization systems. The results were as follows: (1) Concentrations of Mn in maize under NPKM and NPK treatments were significantly higher than those in M and control treatments. The concentration of Zn in grain of maize was similar under different treatments. The control treatment had the highest concentration of Zn in stalk, while NPKM treatment had the lowest one. (2) Contents of Mn and Zn increased with increasing yields of maize, and the regression relationship between the contents and yield of stalk was better than that between the contents and yield of grain. (3) Most of Mn and almost half of Zn were concentrated in stalk. The distribution and use efficiency of micronutrients were optimized under NPKM and NPK treatments. Returning the stalk to soil is an effective strategy for micronutrients sustainable utilization in agro-ecosystem.
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PMID:[Determination of concentrations and distributions of Mn and Zn in maize under different fertilization regime using ICP-AES]. 2132 52

The recycling rate and budget of Mn and Cu under different fertilization regimes by using long-term field experiment and ICP-AES analysis were investigated in the present paper. The results showed that the recycling rates of Mn and Cu were greater than 80% because of sediment recycling type, and the values increased with the amount of feed stuffs increasing. Both the two elements under different fertilization regimes showed budget deficit, with the deficit order of M< (or < or =)NPK + M < CK < NPK, showing that chemical fertilizer application might induce severe deficit, while application of recycling organic matter might minimize the unbalance.
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PMID:[The recycling rate and budget of trace element Mn and Cu in agroecosystem using ICP-AES]. 2225 May 69

Large quantity of composite propellants is produced as waste due to life expiry of missiles/rejection of propellant lots during manufacturing. The environmental protection agency does not allow the hazardous materials for open burning/open detonation. Therefore, a systematic study has been carried out to develop a method for the disposal of composite propellant into liquid fertilizer without affecting the environment. In this study, propellant compositions were digested in dilute nitric acid followed by neutralization with 5M KOH solution to get precipitated out aluminium as aluminium hydroxide and finally the obtained liquid was treated with orthophosphoric acid for further neutralization. The liquid fertilizer, thus, obtained was characterized for nitrate and phosphate content using ion chromatography while ICP-AES was used for the estimation of potassium, aluminium and other noxious metallic elements such as Pb, Cd, As, Cr, Cu, Ni and Zn. The analyses data indicate that liquid fertilizer is free from aluminium and noxious metallic elements while ratio of nitrogen, phosphorous and potassium are close to the Indian NPK value.
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PMID:Development of an eco-friendly method to convert life expired composite propellant into liquid fertilizer. 2226 54

The concentration and distribution of Mn and Zn in soil and soybean in lower reach of Liaohe River Plain were investigated with ICP-AES analysis. The results showed that the available Zn in soils was close to the critical value and the monitoring should be strengthened. Zn concentration in seed and stalk, coupled with Mn in stalk, was not affected by fertilization types, while Mn concentration in seed under NPK and NPKO treatments was significantly higher than that with O and CK treatments. Application of organic and inorganic fertilizer increased crop biomass, and consequently increased Mn and Zn storage in soybean. In soil-crop system, Mn and Zn under different fertilization regimes showed budget deficit, with the deficit order of NPKO < O < CK < NPK, indicating that nutrient cycling could decrease the deficit significantly and keep the ecological systems more sustainable.
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PMID:[Analysis on concentration, distribution and budgets of Mn and Zn in soybean by using ICP-AES]. 2384 39