Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tachykinins in the mammalian brain are derived from two genes: preprotachykinin A, encoding substance P and neurokinin A, and preprotachykinin B, encoding neurokinin B. Using immunocytochemistry and in situ hybridization histochemistry, we have investigated the ontogeny and distribution of substance P and neurokinin B in various cortical areas of rat cerebrum at different prenatal and postnatal ages. Preprotachykinin A mRNA-positive and -immunoreactive cells were first detected at birth and were abundant in layer VIb and the adjacent white matter in the cingulate and frontal cortices. By postnatal day 5, the numbers of substance P-expressing cells were diminished dramatically in those layers. However, their number gradually increased and spread out laterally to cover parietal and temporal cortices from P5 to P15 in layer V. At these stages, cells were also observed in layer II, although fewer in number. The number of substance P mRNA-positive neurons and substance P-immunoreactive cells decreased gradually from P10 and P15 onward, respectively. On the other hand, expression of neurokinin B, as detected by in situ hybridization histochemistry or immunocytochemistry, was not evident until P10. Neurons expressing this tachykinin were concentrated in layer II, and to a lesser extent in layers V and VI. This pattern of distribution was retained through P45. The present data show a marked difference between these two tachykinins in onset and trends of development, suggesting functional independence of these two tachykinins in the cerebral cortex.
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PMID:Ontogeny of the distribution of tachykinins in rat cerebral cortex: immunocytochemistry and in situ hybridization histochemistry. 751 May 88

Assessment of growth regulator and NPK fertilization effects are important tools for flower stimulation and yield improvement in cucurbits. This investigation demonstrates the comparative male-female flower induction and fruit yield of small sized bitter gourd treated with NPK fertilizers and plant growth regulators. Namely, two experiments having three replicates were conducted in a Randomized Complete Block Design (RCBD) with NPK fertilization and plant growth regulators-GA3, NAA and Ethophon application on small sized bitter gourd-genotype BG5 at the research field of the Bangabandhu Sheikh Mujibur Rahman Agricultural University (BSMRAU). In experiment 1, different doses of NPK fertilizers comprised of 10 treatments and in that of experiment 2, different levels of plant growth regulators indicated 10 treatments. The results indicated that application of different doses of NPK fertilizer and plant growth regulators significantly (< or = 0.05) influenced over the flower initiation and fruit setting. The application of N90-P45-K60 fertilizer along with Ethophon spraying resulted in the better yield of small sized bitter gourd.
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PMID:Flower synchrony, growth and yield enhancement of small type bitter gourd (Momordica charantia L.) through plant growth regulators and NPK fertilization. 2489 96