Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A diet containing 0.3% cholesterol was given to male New Zealand rabbits for 16 weeks; this produced atherosclerotic lesions (fatty streaks) on 80% of the intimal surface of the thoracic aorta and on 45% of the intimal surface of the abdominal aorta. The endothelium-dependent relaxations induced by acetylcholine, substance P and ionophore A23187 were inhibited in the atherosclerotic aortas. Besides the endothelium-independent relaxations induced by nitroglycerine, the relaxations induced by atrial natriuretic peptide (ANF) were also significantly reduced in the more atherosclerotic thoracic aorta. In bioassay experiments it was found that acetylcholine and substance P caused a smaller release of endothelium-derived relaxing factor (EDRF) from atherosclerotic thoracic aortas than from control thoracic aortas: the EDRF released by the vasodilators evoked less relaxation in atherosclerotic detector abdominal aortas than in control detector abdominal aortas. Nitric oxide evoked significantly less transient relaxation in the atherosclerotic thoracic and abdominal aortas than in the respective control tissues. The data indicate that as experimental atherosclerosis in the rabbit progresses, both vascular activity and EDRF release become affected; this leads to a complete loss of endothelium-dependent relaxation in the more atherosclerotic blood vessels.
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PMID:Release and vascular activity of endothelium-derived relaxing factor in atherosclerotic rabbit aorta. 170 15

The distribution of several neuropeptides in subepicardial atrial ganglia was examined in the rat heart by using immunohistochemical techniques. Some of the ganglion cells in the right atrium exhibited neuropeptide Y-immunoreactivity while no immunostaining was found with antisera against atrial natriuretic polypeptide (ANF), substance P, vasoactive intestinal polypeptide (VIP), and calcitonin gene-related peptide (CGRP). Nerve fibers in and around the ganglia showed neuropeptide Y, calcitonin gene-related peptide and vasoactive intestinal polypeptide immunoreactivities. Some of these immunoreactive fibers (substance P, calcitonin gene-related peptide, neuropeptide Y) formed relatively dense networks around blood vessels and capillaries. Atrial natriuretic polypeptide-like immunoreactivity which was present in atrial myocytes failed to show up in any neuronal elements in the rat heart.
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PMID:Neuropeptides in atrial subepicardial ganglia of rats. 172 37

The distribution of several neuropeptides in subepicardial atrial ganglia was examined in the rat heart by using immunohistochemical techniques. Some of the ganglion cells in the right atrium exhibited neuropeptide Y-immunoreactivity while no immunostaining was found with antisera against atrial natriuretic polypeptide (ANF), substance P, vasoactive intestinal polypeptide (VIP), and calcitonin gene-related peptide (CGRP). Nerve fibers in and around the ganglia showed neuropeptide Y, calcitonin gene-related peptide and vasoactive intestinal polypeptide immunoreactivities. Some of these immunoreactive fibers (substance P, calcitonin gene-related peptide, neuropeptide Y) formed relatively dense networks around blood vessels and capillaries. Atrial natriuretic polypeptide-like immunoreactivity which was present in atrial myocytes failed to show up in any neuronal elements in the rat heart.
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PMID:Neuropeptides in atrial subepicardial ganglia of rats. 184 39

The present work was to investigate the distribution of Substance K (SK) in the rat heart and its cardiovascular effects. The content of SK-like immunoreactive material (SKLI), determined by using specific radioimmunoassay, was higher in the atrium (19.9 +/- 3.5 pmol/g tissue) than in the ventricle (4.1 +/- 0.8 pmol/g tissue). SKLI in the heart existed in the nerves fibers and its molecular form was identical with synthetic SK. There were high affinity binding sites of SK on the cardiohybricyte CP 8401: KD = 0.161 nmol/L, Bmax = 8.08 pmol/L. SK stimulated the release of ANF from the cardiohybricytes and from the isolated rat atria. Furthermore, SK injected intravenously induced a hypotensive effect in rats, and decreased left ventricle end systolic pressure (LVESP), +/- LVdp/dtmax, as well as slightly increased heart rate (HR). In isolated Langendorff perfusion heart of rat, SK increased HR, LVdp/dtmax, left ventricle peak systolic pressure (LVPSP) and perfusion pressure (PP). These effects of SK were inhibited by a tachykinin receptor antagonist, (D-Pro2, D-Trp7.9)-SP. These findings suggest that SK exist in the heart and might be able to bind with its specific binding sites on the cardiocytes, thus inducing the release of ANF from the atrium and regulating cardiovascular functions.
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PMID:[Distribution of substance K in the rat heart and its cardiovascular effects]. 255 Oct 44

An analogue of human melanin-concentrating hormone (MCH) suitable for radioiodination was designed in which Tyr13 and Val19 of the natural peptide were replaced by phenylalanyl and tyrosyl residues: [Phe13, Tyr19]-MCH. The peptide was synthesized by the continuous-flow solid-phase methodology using Fmoc-strategy and polyhipe PA 500 and PEG-PS resins. The linear MCH peptides with either acetamidomethyl-protected or free cysteinyl residues were purified to homogeneity and cyclized by iodine oxidation, yielding the final product with the correct molecular weight of 2434.61. Radioiodination of the C-terminal tyrosine was carried out enzymatically using solid-phase bound glucose oxidase/lactoperoxidase, followed by purification on a reversed-phase mini-column and by high-pressure liquid chromatography. The resulting [125I]-[Phe13, Tyr19]-MCH tracer was the first radiolabelled MCH peptide suitable for radioreceptor assay: saturation binding analysis using mouse G4F-7 melanoma cells demonstrated the presence of 1090 MCH receptors per cell. The dissociation constant (KD) was 1.18 x 10(-10) M, indicating high-affinity MCH receptors on these cells. MCH receptors were also found in other cell lines such as mouse B16-F1 and G4F and human RE melanoma cells as well as in PC12 and COS-7 cells. Competition binding analyses with a number of other peptides such as alpha-MSH, neuropeptide Y, substance P and pituitary adenylate cyclase activating peptide, demonstrated that the binding to the MCH receptor is specific. Atrial natriuretic factor was found to be a weak competitor of MCH, indicating topological similarities between MCH and ANF when interacting with MCH receptors.
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PMID:Synthesis and iodination of human (phenylalanine 13, tyrosine 19) melanin-concentrating hormone for radioreceptor assay. 922 84

The data obtained suggest a potential mechanism that may account for the selective control of adrenaline and noradrenaline release from adrenal chromaffin cells. Some neuropeptides seem to affect in a different way the release from A- and NA-adrenal cells by means of regulating a set of cytochemical events: specific reception of cholinergic transmitters, expression of the second messenger system including cGMP and changes in Ca channels activity, changes in the catecholamine biosynthesis in adrenal chromaffin cells. Modulating function of substance P, endothelins, PACAP, and ANF, is discussed.
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PMID:[Peptide mediators in adrenal chromaffin cells: regulation of catecholamine selective secretion]. 1009 82