Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20366 (
substance P
)
21,176
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Purified rat peritoneal mast cells have a 10-20-fold higher dipeptidyl peptidase II (
DPP II
) activity as compared with that of macrophages from the same source. Upon stimulation with the secretagogue Compound 48/80,
DPP II
is released from peritoneal-lavage cells and from purified mast cells, but not from purified macrophages, in a dose-dependent manner. Maximally, about one-third of the
DPP II
present in peritoneal-lavage cells is released.
Substance P
and the antigen/IgE system probably produce a similar effect. Both histamine and Zn2+, two ingredients of mast-cell granules, strongly inhibit
DPP II
at concentrations reported to occur in the granules. A possible role of mast-cell
DPP II
in the remodelling of connective tissue is discussed.
...
PMID:Rat peritoneal mast cells release dipeptidyl peptidase II. 243 77
