Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Withdrawal behavior in morphine-dependent rats precipitated by naloxone was attenuated after pretreatment with the tetrapeptide tuftsin and to some extent by its synthetic derivative [Lys4]-tuftsinyltuftsin. The tetrapeptide fragment (1-4) of Substance P was ineffective in suppressing morphine-withdrawal behavior, whereas its C-amide exerted only weak action. Possible involvement of an immunological mechanism is discussed.
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PMID:Modification of morphine withdrawal: effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1-4) of substance P and its amide. 241 28