Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The spinal afferent neurons serving the stomach influence a variety of different gastric functions that together can be considered protective; it is not known whether the stomach can adapt to the loss of these neurons. We now report that in conscious rats pretreated with capsaicin to lesion small-diameter afferents, but not in control rats, i.v. infusion of substance P for 6 h increased the abundance of mRNA encoding somatostatin in antrum; there was no change in a reference mRNA, glyceraldehyde phosphate dehydrogenase. Substance P had no effect on somatostatin mRNA in the gastric corpus in either control or capsaicin-treated rats. An increased sensitivity of antral somatostatin cells to substance P may be one of the adaptive changes that occurs in the stomach of capsaicin-treated rats.
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PMID:Stimulation of gastric somatostatin mRNA abundance by substance P in capsaicin-treated rats. 752 52