Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ciliary frequency was measured in cultivated ciliated human cells of the upper respiratory tract. An attempt was made to influence this isolated system pharmacologically. Previously, contradictory results have been published regarding the effects of parasympathomimetic and sympathomimetic drugs. We investigated the muscarinic agonist carbachol and the beta 2-adrenoreceptor stimulating drug clenbuterol. Carbachol (10(-3) M) did not modify the ciliary frequency in 6 experiments neither at 37 degrees C nor at 24 degrees C, where the basal frequency was reduced. Spiropent (10(-5) M), a pharmaceutical preparation of clenbuterol and lactose, increased the ciliary frequency in 3 experiments. Clenbuterol, tested in the same concentration in 1 experiment, also caused an increase. Lactose was without effect. The secretolytic drug ambroxol did not influence the ciliary frequency. The neuropeptide substance P which causes an increase in ciliary frequency in the respiratory tract of rabbits in vivo, had no effect on isolated human ciliated cells indicating an indirect effect of this peptide. Calcitonin gene-related peptide which co-exists with substance P in sensory neurons of the airways, increased the ciliary frequency in 1 out of 6 experiments. In conclusion, our results indicate that ciliary activity can be directly modified via beta 2-adrenoreceptors. Other putative neuronal mediators did not reveal clearcut direct activity.
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PMID:[Pharmacologic studies of cultivated human ciliated cells of the upper respiratory tract]. 246 52

OBJECTIVE To investigate the effects of meloxicam administration before long-distance transport on inflammatory mediators and leukocyte function of cattle at feedlot arrival. ANIMALS 60 healthy yearling beef steers. PROCEDURES Single-source steers were assigned to a transported (n = 40) or nontransported (20) group. Then, half of the steers within each group were assigned to receive meloxicam (1 mg/kg, PO) or a lactose placebo (1 bolus/steer, PO). All steers were transported approximately 1,300 km overnight to a feedlot; however, the nontransported group was moved before treatment (meloxicam or placebo) administration and allowed a 17-day acclimation period, whereas the transported group was moved immediately after treatment administration on day -1. Blood samples for measurement of inflammatory mediators and leukocyte function were collected from all steers on days -1, 0, and 3. RESULTS For steers that received meloxicam, mean plasma meloxicam concentration for the transported group was significantly greater than that for the nontransported group on day 0. For steers that received the placebo, mean haptoglobin-matrix metalloproteinase-9 complex for the transported group was significantly greater than that for the nontransported group on day 0. Mean haptoglobin concentration, neutrophil L-selectin intensity, and polymorphonuclear leukocyte count for the transported group were significantly greater than those for the nontransported group. Mean substance P concentration for nontransported steers that received meloxicam was significantly lower than that for the other 3 treatment groups. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated meloxicam administration to healthy steers immediately before long-distance transport did not significantly mitigate the effects of transport-induced stress on leukocyte function or inflammatory markers.
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PMID:Effect of oral administration of meloxicam prior to transport on inflammatory mediators and leukoctye function of cattle at feedlot arrival. 2918 92