Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P20366 (substance P)
 21,176 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Substance P has a powerful excitant action on spinal motoneurons of the newborn rat, and the action is specifically antagonized by Lioresal, which also readily blocks spinal reflexes involving primary afferent transmission. Substance P is highly concentrated in bovine and feline dorsal roots as well as in the dorsal part of the dorsal horn of cat spinal cord. There is evidence that substance P is synthesized in spinal ganglia, transported through the dorsal roots and stored in the axon terminals of primary afferent neurons. These and other results suggest that the undecapeptide substance P, or one of its shorter C-terminal analogues, functions as an excitatory transmitter of the primary afferent fibers.
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PMID:Substance P and primary afferent transmission. 19 49

The mode of action of synthetic substance P on intestinal motility was investigated in vitro. Results have indicated that substance P has a major stimulating effect on the intestine by eliciting mechanical contraction and bursts of spike potentials. On a molar basis, substance P was 1.6 X 10(3) times more potent than acetylcholine. Unlike the gastrin peptide analogue caerulein, the effects of which were mediated through the release of acetylcholine from the enteric plexuses, the site of action of substance P appeared to be directly on the muscle cells because its effects were resistant to atropine, tetrodotoxin, and Lioresal. These data strongly suggest a possible physiological role of substance P in the modulation of intestinal longitudinal muscle motor activity.
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PMID:Effect of substance P on intestinal muscle. 62 Aug 95

Beta-(4-chlorophenyl)-GABA (Baclofen, Lioresal) antagonized the excitant actions of acetylcholine and substance P to comparable extents. L-glutamate-induced excitation was affected to a lesser extent. These findings do not support the suggestion that beta-(4-chlorophenyl)-GABA is a specific substance P antagonist.
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PMID:Is beta-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons? 127 5