Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P20366 (
substance P
)
21,176
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Estrogen receptor a (ERa) signaling in the ventromedial hypothalamus (VMH) contributes to energy homeostasis by modulating physical activity and thermogenesis. However, the precise neuronal populations involved remain undefined. Here, we describe six neuronal populations in the mouse VMH by using single-cell RNA transcriptomics and in situ hybridization. ERa is enriched in populations showing sex biased expression of reprimo (
Rprm
),
tachykinin 1
(
Tac1
), and prodynorphin (
Pdyn
). Female biased expression of
Tac1
and
Rprm
is patterned by ERa-dependent repression during male development, whereas male biased expression of
Pdyn
is maintained by circulating testicular hormone in adulthood. Chemogenetic activation of ERa positive VMH neurons stimulates heat generation and movement in both sexes. However, silencing
Rprm
gene function increases core temperature selectively in females and ectopic
Rprm
expression in males is associated with reduced core temperature. Together these findings reveal a role for
Rprm
in temperature regulation and ERa in the
masculinization
of neuron populations that underlie energy expenditure.
...
PMID:Hypothalamic estrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure. 3237 34
